A5064868294- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Pharmacogenetics and Drug Metabolism
- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Vitamin K Research Studies
- Cell Adhesion Molecules Research
- Hemophilia Treatment and Research
- Blood disorders and treatments
- Inflammasome and immune disorders
- Chronic Myeloid Leukemia Treatments
- S100 Proteins and Annexins
- Blood groups and transfusion
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Hormonal Regulation and Hypertension
Centro Regional de Hemodonación
2015-2024
Universidad de Murcia
2015-2024
Hospital General Universitario Morales Meseguer
2003-2023
University of Kentucky
2023
Instituto Murciano de Investigación Biosanitaria
2018-2023
Centro de Investigación Biomédica en Red
2018
Universitat Autònoma de Barcelona
2006
Hospital de Sant Pau
2006
Hospital Clínic de Barcelona
2006
Hospital General Universitario de Alicante Doctor Balmis
2005
The widespread use of aspirin requires clarification the resistance phenomenon. Most studies on this field are focused patients which may affect action aspirin.We evaluated biological efficacy in healthy subjects.Agonist-induced platelet aggregation was fully abrogated by 100 mg all individuals. By contrast, with function analyzer-100 device, 33.3% subjects displayed no response. This failure overcome 500 or vitro treatment blood 30 mumol/L acetylsalicylic acid. Intake efficiently reduced...
Atrial fibrillation (AF) patients experience adverse cardiovascular events (ACEs) despite anticoagulant therapy. We reported that rs2431697 of miR-146a, a negative regulator inflammation, predicts ACEs in with AF. The relationship between neutrophil extracellular traps and thrombogenesis is known. Thus, our aim was to evaluate the role trap compounds as prognostic markers AF study whether miR-146a affects NETosis.We included 336 steadily anticoagulated median follow-up 7.9 years...
STUDY QUESTIONCould peritoneal fluid (PF) from patients with endometriosis alter the microRNA (miRNA) expression profile in endometrial and endometriotic cells patients?
Abstract MicroRNAs markedly affect the immune system and have a relevant role in CVD autoimmune diseases. Yet, no study has analyzed their involvement atherothrombosis related to APS SLE patients. This intended to: 1) identify characterize microRNAs linked SLE; 2) assess effects of specific autoantibodies. Six microRNAs, involved development, were quantified purified leukocytes from 23 64 patients, 56 healthy donors. Levels neutrophils lower than Gene protein expression miRNA...
Neutrophil extracellular traps (NETs) induce a procoagulant response linking inflammation and thrombosis. Low levels of miR-146a, brake inflammatory response, are involved in higher risk for cardiovascular events, but the mechanisms explaining how miR-146a exerts its function remain largely undefined. The aim this study was to explore impact deficiency NETosis both, sterile non-sterile models vivo, inquire into underlying mechanism. Two were performed: 1) Ldlr-/- mice transplanted with bone...
A nucleotide change (G to transition) at position 20210 has recently been demonstrated be a risk factor for venous thrombosis. The relevance of this polymorphism thrombotic disease was investigated by genotypic identification in three prospective case–control studies: 101 case patients with acute coronary heart (CHD), 104 cerebrovascular (CVD), 82 confirmed diagnosis deep thrombosis (DVT), and one control age‐ sex‐matched each patient. prevalence the genetic variation significantly...
<h3>Background</h3> The advent of anti-TNFα drugs has considerably improved medical management in Rheumatoid Arthritis (RA) patients, although it been reported to be ineffective a fraction them. MicroRNAs (miRNAs) are small, non-coding RNAs that act as fine tuning regulators gene expression. Targeting miRNAs by gain or loss function approaches have brought therapeutic effects various disease models. <h3>Objectives</h3> To investigate serum miRNA levels during the induction therapy RA...
The variability of the platelet GP Ia/IIa density has been associated with 807 C/T polymorphism (Phe 224) Ia gene in American Caucasian population. We have investigated genotype and allelic frequencies this Spanish Caucasians. T allele was found 35% 284 blood donors analyzed. confirmed 159 healthy subjects a significant association between density. correlated high number molecules on surface. In addition, we observed similar expression protein other cell types. responsiveness to collagen...
The identification of genetic and environmental factors that could improve the benefit/risk ratio thrombolytic therapy in patients with ischemic stroke is crucial.We studied role efficacy side-adverse effects 2 involved structure stability fibrin clot: fibrinogen levels factor XIII (FXIII) V34L, a common functional polymorphism. Our study enrolled 200 consecutive who received intravenous recombinant tissue plasminogen activator.Patients FXIII V/V genotype low (<3.6 g/L) displayed best...
High levels of factor XI (FXI) increase the risk thromboembolic disease. However, genetic and environmental factors regulating FXI expression are still largely unknown. The aim our study was to evaluate regulation by microRNAs (miRNAs) in human liver. In silico prediction yielded four miRNA candidates that might regulate expression. HepG2 cells were transfected with miR-181a-5p, miR-23a-3p, miR-16-5p miR-195-5p. We used mir-494, which not predicted bind F11, as a negative control. Only...
Summary There are few biomarkers able to forecast new thrombotic events in patients with AF. In this framework, microRNAs have emerged as critical players cardiovascular biology. particular, miR-146a-5p is recognised an important negative regulator of inflammation. This study aims evaluate the prognostic role and biological effect functional MIR146A polymorphisms, rs2431697 rs2910164, non-valvular atrial fibrillation (AF) under oral anticoagulation. We studied 901 permanent/paroxysmal AF...
We aimed to identify the plasma miRNA profile of antiphospholipid syndrome (APS) patients and investigate potential role specific circulating miRNAs as non-invasive disease biomarkers. Ninety APS 42 healthy donors were recruited. Profiling by PCR-array in identified a set differentially expressed collectively involved clinical features. Logistic regression ROC analysis signature 10 ratios biomarkers disease. In addition, was related fetal loss, atherosclerosis, type thrombosis, correlated...
The platelet membrane glycoprotein (GP) Ib alpha plays a key role in the initial formation of thrombi. Polymorphisms (VNTR and HPA-2) this receptor are associated with increased risk coronary heart disease (CHD) cerebral vascular (CVD). We investigated whether recently described polymorphism (S/R), due to single base change (T-->C) five nucleotides upstream initiator codon GPIb alpha, might influence expression protein, be implicated development arterial thrombosis. One hundred thirty nine...