A5015337616- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- T-cell and Retrovirus Studies
- Mast cells and histamine
- Glycosylation and Glycoproteins Research
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Spanish Literature and Culture Studies
- Cancer-related Molecular Pathways
Hospital General Universitario Morales Meseguer
2015-2025
Centro Regional de Hemodonación
1996-2024
Universidad de Murcia
2013-2024
Centro de Investigación Biomédica en Red
2024
Centre for Biomedical Network Research on Rare Diseases
2024
Clinica Universidad de Navarra
2010
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2009
Complejo Hospitalario de Salamanca
2004-2009
Hospital Universitario Reina Sofía
2009
Centro Médico Sanitas Murcia
2001
Bone marrow infiltration (BMI), categorized as an extra-nodal site, affects stage and is associated with poor prognosis in newly diagnosed lymphoma patients. We have evaluated the accuracy of PET/CT bone biopsy (BMB) to assess BMI 372 patients [140 Hodgkin Lymphoma (HL) 232 High Grade B-cell non-Hodgkin (HG B-NHL), among them 155 Diffuse Large B-Cell (DLCL)]. For HL cases, taking into account PET/CT, sensitivity, negative predictive value (NPV) were 96.7, 99.3, 99.3% while those BMB 32.3,...
Among patients with B-cell chronic lymphoid leukemia, those 13q14 deletion have a favorable outcome. However, whether the percentage of cells 13q- influences prognosis or biological characteristics this disease is unknown. We analyzed clinico-biological and outcome leukemia loss 13q as sole cytogenetic aberration.Three hundred fifty were studied. Clinical data collected fluorescence in situ hybridization molecular studies carried out. In addition, gene expression profile was obtained by...
// Anna Puiggros 1, 2 , Rosa Collado 3 Maria José Calasanz 4 Margarita Ortega 5 Neus Ruiz-Xivillé 6 Alfredo Rivas-Delgado 7 Elisa Luño 8 Teresa González 9 Blanca Navarro 10 MaDolores García-Malo 11 Alberto Valiente 12 Ángel Hernández 13 María Ardanaz 14 Ángeles Piñan 15 Laura Blanco 16 Hernández-Sánchez 17 Ana Batlle-López 18 Rocío Salgado 19 Marta Salido Ferrer Pau Abrisqueta Eva Gimeno 1...
The variability of the platelet GP Ia/IIa density has been associated with 807 C/T polymorphism (Phe 224) Ia gene in American Caucasian population. We have investigated genotype and allelic frequencies this Spanish Caucasians. T allele was found 35% 284 blood donors analyzed. confirmed 159 healthy subjects a significant association between density. correlated high number molecules on surface. In addition, we observed similar expression protein other cell types. responsiveness to collagen...
// Gonzalo Blanco 1, 2, 3 , Anna Puiggros 2 Panagiotis Baliakas 4 Anastasia Athanasiadou 5 MªDolores García-Malo 6 Rosa Collado 7 Aliki Xochelli 4, 8 María Rodríguez-Rivera Margarita Ortega 9 Mª José Calasanz 10 Elisa Luño 11 MªTeresa Vargas 12 Javier Grau 13 Carolina Martínez-Laperche 14 Alberto Valiente 15 Cervera 16 Achilles Anagnostopoulos Eva Gimeno 17 Eugènia Abella Evangelia Stalika Jesús Hernández-Rivas 18...
Structural variations (SVs) are common in haematological neoplasms.1 Although most SVs have canonical breakpoints, virtually all atypical rearrangements that can be of difficult diagnosis. High-throughput sequencing (HTS) has improved the study SVs, complementing cytogenetics. However, short reads (<150 bp) generated by HTS might lead to inaccurate mapping.2 This may not suppose a mere technical pitfall, but problem faced, guarantee monitoring and guided-treatment patients bearing when...
The goal of the study is to determine extent structural brain abnormalities in a multicenter sample children and adolescents with recent-onset first episode psychosis (FEP), compared healthy controls. Total lobar volumes those gray matter (GM), white matter, cerebrospinal fluid (CSF) were measured 92 patients FEP 94 controls, matched for age, gender, years education. Male (n = 64) showed several significant differences when controls 61). GM volume male was reduced whole frontal parietal...
Abstract Chediak– H igashi syndrome ( CHS ) is a rare autosomal recessive disease resulting from mutations in the LYST / 1 gene, which encodes for 429 kD protein, 1/ , that regulates vesicle trafficking and determines size of lysosomes other organelles. To date, 60 different have been characterized, reasonably straightforward phenotype–genotype correlation has suggested. We describe two patients on opposite ends clinical spectrum with novel missense mutations. characterized these terms their...
Peripheral expansion of cytotoxic T lymphocytes (CTL) derived from the graft in initial stages allogeneic haematopoietic stem cell transplantation (alloHSCT) immune recovery is a well-known physiological event. The description symptomatic large granular lymphocyte leukaemia this setting may generate uncertainty, mostly those cases which CTL (CTLe) persists beyond early period. We aimed to assess nature CTLe during post-alloHSCT period 154 adult patients with long-term surveillance. studied...
Deletion of 13q14 as the sole abnormality is a good prognostic marker in chronic lymphocytic leukemia (CLL). Nonetheless, value reciprocal translocations [t(13q)] with related 13q losses has not been fully elucidated. We described clinical and biological characteristics 25 CLL patients t(13q), compared 62 carrying interstitial del(13q) by conventional G‐banding cytogenetics (CGC) [i‐del(13q)] 295 only detected fluorescence situ hybridization (FISH) [F‐del(13q)]. Besides from FISH panel...
Thirty patients diagnosed with breast cancer were included in a prospective randomized study comparing the vivo priming effect of bioequivalent doses glycosylated (lenograstim) and nonglycosylated (filgrastim) rG‐CSF administration. Analysis efficacy equivalent biological both rG‐CSFs showed no significant differences either mobilization subpopulations PBPC considered (CD34 + , CD34 /38 − /DR ), content such cell subsets leukapheresis product, or cost collection procedures between...
Abstract Several studies have reported uneven results when evaluating the prognostic value of bone marrow biopsy ( BMB ) and PET / CT as part staging diffuse large B‐cell lymphoma DLBCL ). The heterogeneity inclusion criteria not taking into account selection collinearity biases in analysis models might explain these discrepancies. To address this issue we carried a retrospective multicenter study including 268 patients with available at diagnosis where estimated both prognosis impact...
Abstract: We performed a prospective study in 17 consecutive patients following autologous bone marrow (BM) or rhG‐CSF primed peripheral blood stem cell (PBSC) transplantation, with the objective of comparing immune recovery between both procedures and to evaluate results mobilized transplantation (PBSCT). Kinetics reconstitution showed differences, faster CD3+ CD8+ T cells, more rapid sustained CD8 ± /CD56+ natural killer (NK) cells PBCSCT group. Autologous (ABMT) was associated improved...
Abstract Although cryopreservation of human bone marrow has become very common in modern medicine, the knowledge on effects this procedure hemopoietic cells is still limited. We herein have investigated whether process concentrating to its buffy coat, exposure cryoprotectant dimethyl sulfoide (DMSO), and/or rate controlled freezing/thawing procedures modifies flow cytometric analysis cells. found that both DMSO freezing significantly relative proportions cell subsets and intensity expression...
The role of imatinib in childhood Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) has not been established. We treated four children with combination conventional chemotherapy (CT) before stem cell transplantation (SCT). Response evaluation consisted fluorocytometric analysis minimal residual disease (MRD) and standard qualitative RT-PCR follow-up.
Despite the longer survival achieved in multiple myeloma (MM) patients due to new therapy strategies, a concern is emerging regarding an increased risk of secondary primary malignancies (SPMs) and how characterize those at risk. We performed retrospective study covering 28-year follow-up period (1991-2018) tertiary single institution.Data 403 MM were recorded compared with epidemiologic register population area covered by our centre, calculating standardize incidence ratio (SIR) for...
Abstract An increasing numbers of patients are being diagnosed with asymptomatic early-stage chronic lymphocytic leukemia (CLL), no treatment indication at baseline. We applied a high-throughput deep-targeted analysis, especially designed for covering widely TP53 and ATM genes, in 180 inactive disease diagnosis, to test the independent prognostic value CLL somatic recurrent mutations. found that 40/180 harbored least one acquired variant ( n =17, 9.4%), NOTCH1 =14, 7.7%), 7.7%) SF3B1 =10,...
In the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component FLIPI and FLIPI2, most widely used outcome scores. During previous decade, several studies explored role FDG-PET/CT for detecting nodal extranodal disease, with only one large study comparing both techniques.The aim our was to evaluate diagnostic accuracy prognostic impact procedures in retrospective cohort 299 FL patients tests performed at diagnosis. order avoid collinearity bias, FLIPI2...
Background: Assessment of bone marrow infiltration (BMI) is part the initial staging mantle cell lymphoma (MCL), although BMI evaluated by biopsy (BMB) not considered significant in MIPI scales, and standardized recommendations remain lacking. Objectives: To evaluate accuracy prognostic impact assessed PET/CT BMB a large series MCL patients. Methods: We deconstructed IPI-NCCN, MIPI, MIPI-c indices as positive if indicated BMB, scan, or combination both. Results: In total cohort (n = 148),...
A 32-year-old human immunodeficiency virus (HIV)-positive male presented with fever and some haemorrhagic vesicles on the soft palate. Three years previously, he had been diagnosed stage IVB, nodular sclerosis Hodgkin lymphoma, treated six cycles of doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD), achieved complete remission. On admission, a full blood count showed: white cell 67·4 × 109/l, haemoglobin concentration 85 g/l platelet 10 109/l. Peripheral films showed 10% blasts (some...