A5053938175- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Renal Transplantation Outcomes and Treatments
- Viral-associated cancers and disorders
- Neurological Complications and Syndromes
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Integrated Circuits and Semiconductor Failure Analysis
- Herpesvirus Infections and Treatments
- Fungal Infections and Studies
- Transplantation: Methods and Outcomes
- Multiple Sclerosis Research Studies
- Chronic Lymphocytic Leukemia Research
- Animal Virus Infections Studies
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiomics and Machine Learning in Medical Imaging
Hospital Universitari i Politècnic La Fe
2016-2025
Instituto de Investigación Sanitaria La Fe
2019-2025
Centro de Investigación Biomédica en Red de Cáncer
2018-2025
Instituto de Salud Carlos III
2023-2025
Weatherford College
2024
Instituto Politécnico Nacional
2024
Aurora Medical Center
2024
Leitat Technological Center
2023
Hospital General Universitario De Valencia
1996
Post-transplant lymphoproliferative disorders (PTLD) are a rare complication after both solid organ (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this single center retrospective study, we compared clinical, biological, histological features, outcomes of PTLD types transplant. We identified 82 (61 SOT 21 allo-HSCT). The presence B symptoms, Waldeyer ring, spleen, central nervous system, liver involvement, advanced Ann-Arbor stage were more frequent in allo-HSCT...
Post-transplantation cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis is being increasingly used in allogeneic hematopoietic stem cell transplantation (allo-HSCT) from HLA-matched related donors (MRDs); however, information regarding the transfusion needs this setting lacking. This study compared RBC and platelet units transfused time to independence according GVHD regimen MRD HSCT. We performed a matched-pair analysis comparing requirements clinical outcomes of...
Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be associated with neurologic complications, data on noninfectious etiologies are scanty. Therefore, we analyzed the incidence, clinical characteristics, risk factors, and influence outcomes of complications (NCs) in 971 consecutive patients hematologic malignancies undergoing allo-HSCT at our center between January 2000 December 2016. We evaluated NCs affecting central nervous system (CNS) peripheral (PNS). The...
Abstract Despite the growing evidence supporting existence of CNS involvement in acute and chronic graft-versus-host disease (CNS-GvHD), characteristics course are still largely unknown. In this multicenter retrospective study, we analyzed clinical, biological, radiological, histopathological characteristics, as well clinical 66 patients diagnosed with possible CNS-GvHD (pCNS-GvHD), selected by predetermined diagnostic criteria. Results were then contrasted depending on whether pCNS-GvHD...
Highlights•CMV DNA is frequently detected in BAL fluid specimens from allo-HSCT.•CMV detection fluids comparable across pneumonia etiologies.•CMV loads are load may predict attributable-pneumonia mortality.SummaryObjectivesTo date no definitive cut-off value for cytomegalovirus (CMV) bronchoalveolar lavage (BAL) has been established to discriminate between CMV and pulmonary shedding allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients.MethodsThe current retrospective study...
Post-transplant cyclophosphamide (PTCy) has emerged as a promising graft-versus-host disease (GvHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no studies have reported the efficacy of GvHD based on PTCy with sirolimus (Sir-PTCy) patients acute myeloid leukemia (AML). In this retrospective study, we analyze use combination PTCy, or without mycophenolate mofetil (MMF), 242 consecutive adult AML undergoing myeloablative first allo-HSCT from different...
Chimeric antigen receptor T-cell therapy (CAR-T) is an effective approach for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). However, some rare variants do not seem to respond as well this redirecting strategy. T-cell/histiocyte-rich (THRLBCL) infrequent subtype of LBCL which typically develops in young, male patients, characterized by aggressive clinical course and chemo-refractory disease.1, 2 THRLBCL has unique biological characteristics a inhibitory tumor immune...
Importance Acute adverse events (AEs) after chimeric antigen receptor (CAR) T-cell infusion are well documented, but less information is available regarding the long-term toxic effects. Objective To assess occurrence of late AEs for adult patients with large B-cell lymphoma (LBCL) treated commercially CD19-targeted CAR T cells. Design, Setting, and Participants A prospective, observational, clinical practice cohort study was conducted from September 1, 2018, to December 31, 2022, among 172...
Risk factors (RFs) and mortality data of community-acquired respiratory virus (CARVs) lower tract disease (LRTD) with concurrent pulmonary co-infections in the setting allogeneic hematopoietic stem cell transplantation (allo-HSCT) is scarce. From January 2011 to December 2017, we retrospectively compared outcome allo-HSCT recipients diagnosed CARVs LRTD mono-infection (n = 52, group 1), those viral, bacterial, or fungal 15, 2; n 20, 3, 11, 4, respectively), having bacterial pneumonia 19, 5)....
We analyzed the incidence, clinical characteristics, prognostic factors, and outcome of central nervous system (CNS) infections in consecutive patients with receiving umbilical cord blood transplantation (UCBT) (n = 343) or HLA-matched sibling donor stem cell (MST) 366). Thirty-four CNS were documented at a median time 116 days after (range, 7 to 1161). The cumulative incidence (CI) risk developing infection was .6% day +30, 2.3% +90, 4.9% 5 years. 5-year CI 8.2% UCBT 1.7% MST (P < .001)....
Background: Charcot Marie Tooth (CMT) disease is the most common form of hereditary neuropathy. Due to high prevalence mild and undiagnosed forms, patients with CMT may be exposed severe neurotoxicity following administration neurotoxic chemotherapies. The aim this report alert oncologists potential precipitate irreversible peripheral neuropathies when administering compounds patients.Material methods: A retrospective research in OncoNeuroTox database was performed (2010–2016), searching for...
There are ABO antigens on the surface of platelets, but whether compatible platelets necessary for transfusions is a matter ongoing debate. We retrospectively reviewed matching platelet in subset patients undergoing autologous haematopoietic progenitor cell transplantation during 14-year period. Our aim was to analyse characteristics and outcomes who received that were or not identical.We analysed 529 consecutive with various haematological non-haematological diseases underwent 553 stem...