A5030444190- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Neurological Complications and Syndromes
- Brain Metastases and Treatment
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Hormonal Regulation and Hypertension
- Cancer Risks and Factors
- Family Support in Illness
- Multiple Myeloma Research and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Head and Neck Cancer Studies
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Vitamin C and Antioxidants Research
- Multiple Sclerosis Research Studies
- Vitamin K Research Studies
West Virginia University
2021-2025
Mayo Clinic
2022-2024
Mayo Clinic in Arizona
2023
WinnMed
2022
The University of Western Australia
2021
Geisinger Medical Center
2018
Medical College of Wisconsin
2000-2006
American College of Radiology
2006
University of Wisconsin–Madison
2006
Revised diagnostic criteria for myeloid neoplasms (MN) issued by the International Consensus Classification (ICC) and World Health Organization (WHO) recommended major change pertaining to TP53-mutated (TP53
Abstract Despite the growing evidence supporting existence of CNS involvement in acute and chronic graft-versus-host disease (CNS-GvHD), characteristics course are still largely unknown. In this multicenter retrospective study, we analyzed clinical, biological, radiological, histopathological characteristics, as well clinical 66 patients diagnosed with possible CNS-GvHD (pCNS-GvHD), selected by predetermined diagnostic criteria. Results were then contrasted depending on whether pCNS-GvHD...
e18526 Background: The prevalence of obesity and metabolic syndrome (MetS) continues to rise, necessitating a deeper understanding their implications for cancer outcomes. Obesity is recognized risk factor acute promyelocytic leukemia (APL). Furthermore, higher body mass index has been linked an increased relapse differentiation syndrome. Despite these findings, literature examining the relationship between long-term survival in APL remains limited. This study evaluates association 5-year...
e23287 Background: Synchronous cancers, defined as ≥2 separate malignancies diagnosed in the same individual within 6 months, pose unique clinical challenges including almost universal exclusion from trials. The prevalence of synchronous cancers has increased, ranging 2% to 17%. biology and risk factors for these is not well understood there a paucity data on features outcomes patients. Methods: We retrospectively reviewed charts patients with at West Virginia University Cancer Institute...
e23297 Background: Nearly 20% of Americans reside in rural communities, defined by the U.S. Census as areas not included within urbanized regions or clusters. Rural communities face significant disparities cancer care access due to geographic isolation, limited healthcare infrastructure, and provider shortages, often resulting delayed diagnosis treatment. Synchronous colorectal cancers (synCRC), two more separate primary CRCs that are diagnosed same individual 6 months, account for less than...
e23172 Background: Acute promyelocytic leukemia (APL) is a curable yet aggressive subtype of acute myeloid (AML) associated with early mortality and treatment-related complications. Appalachia, encompassing West Virginia (WV), region characterized by rural communities, rugged terrain, economic isolation posing challenges to timely effective care for patients. Sociodemographic disparities have been shown negatively impact survival outcomes in AML (Guinter et al., Blood 2023). Similar analysis...
7076 Background: HIV+ patients have an 18-fold increased risk of developing diffuse large B Cell Lymphoma (DLBCL). There is uncertainty in the literature regarding safety and efficacy chimeric antigen receptor T-cell (CAR-T) therapy patients. This study aims to evaluate influence HIV infection on outcomes treated with CD19 targeting CAR-T therapy. Methods: a multicenter retrospective cohort that included co-diagnosis DLBCL who received TriNetX Network, database deidentified electronic...
e19013 Background: The escalating obesity rates in the USA are contributing to an increase associated health complications. Limited data exists regarding and its effects on CAR T-cell outcomes. Our study aimed rigorously evaluate real-world outcomes of patients undergoing CAR-T cell therapy based their BMI. Methods: This multicenter, retrospective cohort analysis compared with normal BMI 18-25 kg/m² (Cohort 1 or C1) high BMI>25 2 C2) using assessment before receiving therapy, TriNetX...
1527 Background: The epidermal growth factor receptor (EGFR) pathway is commonly deregulated in GBMs and its activity has been associated with treatment resistance preclinical models. Accordingly, the Radiation Therapy Oncology Group (RTOG) recently conducted a Phase I/II study of Gefitinib, an EGFR tyrosine kinase inhibitor, combination radiotherapy for newly-diagnosed glioblastoma (GBM) patients. Methods: 178 GBM patients were entered on RTOG 0211 (Phase I: 31 II: 147 patients). maximum...
We present here the second documented case of severe immune checkpoint inhibitor-induced myocarditis successfully treated with abatacept. The patient was started on pembrolizumab for stage IIIA malignant melanoma, and after first dose admitted worsening shortness breath weakness. Her symptoms were refractory to high-dose steroids she decompensated rapidly necessitating cardiopulmonary resuscitation subsequent intubation mechanical ventilation. Intravenous immunoglobulin plasmapheresis did...
Abstract Background Previous population health studies examining adults with acute myeloid leukemia (AML); however many of these, such as the Cancer Genome Atlas, are derived from databases collected by large urban centers. Due to its unique industry and environmental exposures, we hypothesized West Virginia Appalachian may have different mutational trends clinical outcomes. Aims To address concern under‐representation rural minorities in cancer genomic databases, performed exploratory whole...
Our objective was to examine whether dietary intakes of vitamin K1 and K2 were associated with all-cause, cardiovascular disease (CVD)-related cancer-related mortality identify subpopulations that may benefit the most from higher K intakes. Participants Danish Diet, Cancer, Health Study cohort, between 50–65 years age at recruitment, completed a food-frequency questionnaire (FFQ) baseline followed up for cancer-related, CVD-related, all-cause using nationwide registries. Intakes...
e23012 Background: Fellowship programs use a variety of continuity clinic models including general, disease/system specific, or both. The longitudinal timing also varies from 6-months, 1-year, the entirety fellowship. At WVU, we 6-month disease specific model where fellows rotate with attending. Given increasing complexity care for patients oncologic diagnoses, sought to establish general within an academic cancer institute skills needed effectively transition independent practice....
e19022 Background: Many previous population health studies examining adults with acute myeloid leukemia (AML) are derived from national databases within large urban centers. To address the concern of under-representation rural Appalachian in cancer genomic databases, we performed exploratory whole exome sequencing patients newly diagnosed AML. As only stem cell transplantation center state, WVU is uniquely situated to capture most these state and surrounding area. Due its unique industry...