A5028960742- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Atherosclerosis and Cardiovascular Diseases
- Veterinary Medicine and Surgery
- Pediatric Urology and Nephrology Studies
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Scoliosis diagnosis and treatment
- Veterinary Equine Medical Research
- Cancer Research and Treatment
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
University of Córdoba
2015-2025
Hospital Universitario Reina Sofía
2013-2024
Institute for Research in Biomedicine
2021-2024
Institut Scientifique de Santé Publique
2023
UCLouvain
2023
Vrije Universiteit Brussel
2023
Hospital Reina Sofía de Murcia
2018-2020
Universidad de Granada
2016
Cordoba University
2015
To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients.An observational, cross-sectional and descriptive study AS patients from Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Disease Activity Index (BASDAI), Bath Functional (BASFI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)), radiographic data Radiology (BASRI) score) were compared regarding status. A univariate multivariate analysis...
Objective: To describe the prevalence of sarcopenia in rheumatoid arthritis (RA) patients aged ≥65 years and identify risk factors associated with sarcopenia. Methods: This is a multicenter, controlled, cross-sectional study 76 RA age- sex-matched healthy controls. Sarcopenia was defined according to revised criteria European Working Group on Older People (EWGSOP2). Whole-body dual-energy X-ray absorptiometry (DXA) performed. Binary regression used assess relationship between sex, age,...
Objective: To describe the frequency of malnutrition in older patients with rheumatoid arthritis (RA) and investigate associated risk factors. Methods: This multicenter, cross-sectional study included participants aged ≥65 years who met 2010 ACR/EULAR criteria for RA. Nutritional status was assessed using Mini Assessment Short Form (MNA-SF) based on variables, such as albumin level, Geriatric Risk Index (GNRI), vitamin D. Data were also collected epidemiological inflammatory disease...
Abstract Objectives (1) To evaluate clinical and molecular cardiovascular disease (CVD) signs their relationship with psoriatic arthritis (PsA) features (2) to identify a patient profile susceptible benefit from methotrexate (MTX) and/or apremilast regarding CVD risk. Methods This cross‐sectional study included 100 patients PsA age‐matched healthy donors. In addition, an exploratory cohort of 45 biologically naïve treated for 6 months apremilast, MTX or combined therapy according routine...
Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including r-axSpA from national multicentre Spanish REGISPONSER-AS registry. Patients were divided into groups according to mean (<5 years, ≥5 years). Binary logistic regression models adjusted for disease duration constructed used...
Background: This prospective multicenter study developed an integrative clinical and molecular longitudinal in Rheumatoid Arthritis (RA) patients to explore changes serologic parameters following anti-TNF therapy (TNF inhibitors, TNFi) built on machine-learning algorithms aimed at the prediction of TNFi response, based profiles RA patients. Methods: A total 104 from two independent cohorts undergoing 29 healthy donors (HD) were enrolled for discovery validation biomarkers. Serum samples...
We analyzed NAD+ metabolism in patients with rheumatoid arthritis (RA), its association disease activity and clinical outcomes of RA, the therapeutic potential pharmacologic boosting.Our study included 253 participants. In first cohort, comprising 153 RA 56 healthy donors, we assessed levels -related gene pathways. 92 inflammatory molecules by proximity extension assay. second 44 starting anti-tumor necrosis factor (anti-TNF) drugs, evaluated changes their response after 3 months....
Introduction Axial spondyloarthritis (axSpA) is a heterogeneous disease that can be represented by radiographic axSpA (r-axSpA) and non-radiographic (nr-axSpA). This study aimed to evaluate the relationship between markers of inflammation bone turnover in r-axSpA patients nr-axSpA patients. Methods A cross-sectional included 29 patients, 10 20 controls matched for age sex. Plasma related remodeling such as human procollagen type 1 N-terminal propeptide (P1NP), sclerostin, tartrate-resistant...
This study aimed to: 1) analyze the inflammatory profile of Rheumatoid Arthritis (RA) patients, identifying clinical phenotypes associated with cardiovascular (CV) risk; 2) evaluate biologic and targeted-synthetic disease-modifying antirheumatic drugs (b-DMARDs ts-DMARDs': TNFi, IL6Ri, JAKinibs) effects; 3) characterize molecular mechanisms in immune-cell activation endothelial dysfunction. A total 387 RA patients 45 healthy donors were recruited, forming three cohorts: i) 208 established...
Objective: To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods: Cross-sectional study including 347 participants (148 RA, 159 SpA, 40 controls). We measured intima media thickness (cIMT) detection atheromatous plaques ultrasound. recorded disease activity (DAS28-CRP/ASDAS-CRP) traditional cardiovascular risk factors. performed descriptive, bivariate, linear multivariate...
Abstract Background Enthesitis represents one of the most important peripheral musculoskeletal manifestations in patients with axial spondyloarthritis (axSpA). However, studies specifically evaluating Achilles tendon enthesitis and its impact over time are scarce. The objectives this study were to evaluate Achilles’ found at baseline during physical examination on outcome measures after 2 years follow-up ankylosing spondylitis (AS). Methods This was an observational prospective conducted...
<h3>Background:</h3> Rheumatoid arthritis (RA) is a remarkably heterogeneous autoimmune disease whose clinical outcomes with disease-modifying antirheumatic drugs (DMARDs) remain unpredictable in patients. Biomarker identification and personalised medicine an imperative need. <h3>Objectives:</h3> To characterize the molecular landscape of RA patients, by using multi-omic approach involving transcriptomics proteomics assess its association status response. <h3>Methods:</h3> PBMCs from 149...
The objective of this study was to assess the association carotid intima-media thickness (CIMT), and also presence atheromatous plaque, with biological targeted synthetic disease-modifying antirheumatic drugs, in an established cohort patients rheumatoid arthritis (RA).We conducted a cross-sectional observational based on RA registry healthy controls, whom CIMT plaque were assessed by ultrasound. Data collected disease activity, lab results treatments. Descriptive bivariate analyses...
To characterize the splicing machinery (SM) of leukocytes from primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and with (APS + SLE) patients, to assess its clinical involvement.Monocytes, lymphocytes neutrophils 80 patients (22 APS, 35 SLE 23 APS 50 HD were purified, 45 selected SM components evaluated by qPCR-microfluidic array. Relationship features underlying regulatory mechanisms assessed.APS, displayed significant specific alterations in SM-components (SMC),...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a severe multisystem disease, notably heterogeneous in terms of clinical course and therapeutic response, which converts it into significant challenge at the diagnostic treatment levels. <h3>Objectives</h3> This study investigated serum proteomic metabolomic profiles SLE, order to identify new mechanisms underlying relevant patterns. <h3>Methods</h3> Proteomic approaches were used assess levels 184 inflammation organ damage-related...
<h3>Background:</h3> Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by antiphospholipid antibodies and hypercoagulable state, leading to arterial, venous, or microvascular thrombosis, accelerated atherosclerosis obstetric morbidity. Due the heterogeneity of disease, limited effective responses risk recurrences, it crucial develop new approaches that enable more personalized management precise monitoring optimize therapeutic interventions. <h3>Objectives:</h3>...
<h3>Background:</h3> Systemic lupus erythematosus (SLE) exhibits significant heterogeneity in clinical progression and treatment response, posing challenges both diagnosis therapeutic interventions. <h3>Objectives:</h3> To explore mechanisms underlying relevant endotypes SLE patients though the integrated analysis of serum proteomic metabolomic profiles, employing advanced machine learning approaches. <h3>Methods:</h3> Proteomic analyses assessed 184 proteins (Olink) 250 metabolites (NMR,...
<h3>Background:</h3> The association between inflammation and the risk of cardiovascular disease (CVD) has been previously investigated. However, recent emergence concept persistent elevation c-reactive protein (CRP) in context Spondyloarthritis (SpA) garnered increased attention. Despite this, molecular mechanisms underpinning this relationship remain unknown. <h3>Objectives:</h3> <b>1</b>) to explore CVD complications, specifically focusing on endothelial dysfunction occurrence...
<h3>Background:</h3> Rheumatoid arthritis (RA) is a complex chronic inflammatory disease with high heterogeneity. Characterizing the molecular mechanisms linked to different phenotypes might open new opportunities for development of personalized therapeutic approaches. <h3>Objectives:</h3> 1-To characterize circulating proteome in both early and established RA patients. 2- To identify common unique signatures associated activity groups. <h3>Methods:</h3> A cohort 125 patients was included...