A5071663049- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Cardiac pacing and defibrillation studies
- Atherosclerosis and Cardiovascular Diseases
- Chronic Lymphocytic Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Connective tissue disorders research
- Blood disorders and treatments
- Hepatitis C virus research
- Electrolyte and hormonal disorders
- Cardiac Structural Anomalies and Repair
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 and healthcare impacts
- Bone and Joint Diseases
- Ultrasound in Clinical Applications
- Inflammatory Biomarkers in Disease Prognosis
- Biosimilars and Bioanalytical Methods
Universidad de Ecatepec
2024
University of Córdoba
2014-2023
Instituto Maimónides de Investigación Biomédica de Córdoba
2015-2023
Hospital Universitario Ramón y Cajal
2015-2023
Instituto Ramón y Cajal de Investigación Sanitaria
2023
Universidad de Alcalá
2023
Hospital Universitario Reina Sofía
2015-2021
Cordoba University
2018
Institute for Research in Biomedicine
2018
Rheumatology Consultants
2017
Abstract Background Rheumatoid arthritis ( RA ) patients are at increased risk of insulin resistance IR ); however, the specific mechanisms mediating this association currently unknown. Objective To investigate whether inflammatory activity associated with accounts for observed defective glucose metabolism and lipid in these patients. Methods We followed two main strategies: (i) extensive metabolic profiling a cohort 100 50 healthy control subjects (ii) mechanistic studies carried out both...
Background: Pulmonary congestion (PC) is associated with an increased risk of hospitalization and death in patients heart failure (HF). Lung ultrasound highly sensitive for detecting PC. The aim this study to evaluate whether lung ultrasound-guided therapy improves 6-month outcomes HF. Methods: A randomized, multicenter, single-blind clinical trial discharged after decompensated Participants were assigned 1:1 receive treatment guided according the presence signs (semi-quantitative evaluation...
To characterize the splicing machinery (SM) of leukocytes from primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and with (APS + SLE) patients, to assess its clinical involvement.Monocytes, lymphocytes neutrophils 80 patients (22 APS, 35 SLE 23 APS 50 HD were purified, 45 selected SM components evaluated by qPCR-microfluidic array. Relationship features underlying regulatory mechanisms assessed.APS, displayed significant specific alterations in SM-components (SMC),...
<h3>Objectives</h3> To evaluate the application in clinical practice, of acid dissociation patients9 monitoring with subtherapeutic serum concentrations infliximab (IFX), adalimumab (ADL) and etanercept (ETN), using an immmunoassay (ELISA) commercialized (Promonitor®, Proteomika S.L.). <h3>Methods</h3> For 3 years 499 trough samples were analyzed 218 patients different rheumatic pathologies treated IFX (30 patients, 80 samples), ADL (116 238 samples) ETN (72 181 samples). With standard...
<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory disease, of unknown etiology, that mainly affects the axial skeleton and sacroiliac joints in pelvis. Neutrophils are critical actors innate immunity their activation has been involved progression AS symptoms. Recently, NETosis suggested to play central role several pathologic states, including rheumatology diseases. Nevertheless, this process not described yet patients <h3>Objectives</h3> 1) To evaluate characterise...
Aim: To have the knowledge of incidence, clinical, analytical and histological presentations, kidney survival mean contribution treatments to it. Methods: A descriptive, observational transversal study over 156 patients who were diagnosed primary IgA glomerulonephritis between 1994 2018 in Nephrology department Reina Sofía Hospital Córdoba. Variables analysed globally compared group 1 (G1) 1994-2002, 2 (G2) 2002-2010 3 (G3) 2010-2018. Results: Annual incidence 8,4 cases/million, 69,2% men,...
<h3>Objectives</h3> To estimate the prevalence of subclinical synovitis detected by ultrasound in rheumatoid arthritis (RA) and psoriatic (PsA) patients clinical remission receiving anti-TNFα therapy with extended interval administration (EIA). <h3>Methods</h3> Prospective observational study. Population: Patients diagnosed RA PsA, being remission. 12-joint assessment (elbows, wrists, 2nd 3rd metacarpo-phalangeal, knees ankles)<sup>1</sup> was performed, evaluating through B-mode (BM) Color...
<h3>Background</h3> Monocytes play a key role in the pathogenesis of atherothrombosis. It has been described three subsets monocytes with different actions vascular pathology: MON1 (CD14brightCD16-), MON2 (CD14dimCD16bright) and MON3 (CD14brightCD16bright). The distribution these its profile associated cardiovascular disease (CVD) rheumatoid arthritis (RA) remain unravelled. Tocilizumab (TCZ) is new therapeutic drug, very effective RA, but effects on CVD are still unknown....
<h3>Background</h3> Inhibition of the interleukin IL6 receptor pathway by tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). TCZ reduces atherosclerosis markers and improves endothelial function. In peripheral blood, increases percentage natural killer regulatory T cells decreases number inflammatory Th1/Th17 lymphocytes. Monocytes activation neutrophil extracellular traps (NETs) are key players in development cardiovascular disease; however, specific effect on these...
Objective: We aimed to test the non-inferiority of oral versus intravenous hydration in incidence contrast-associated acute kidney injury (CA-AKI) elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan. Methods: PNIC-Na (NCT03476460) is phase-2, single-center, randomized, open-label, trial. included CE-CT scan, >65 years having at least one risk factor for CA-AKI, such as diabetes, heart failure, or an estimated glomerular filtration rate (eGFR) 30–59...
<h3>Background</h3> Rituximab (RTX) has been shown to be successful in the treatment of rheumatoid arthritis (RA), indicating that B cells have an important role this disease. <h3>Objectives</h3> The present study was undertaken investigate mechanisms action RTX on immune and endothelial (EC) vascular system setting RA. <h3>Methods</h3> Purified lymphocytes from five RA patients with high disease activity were treated (1ug/mL) for 24 hours. Then, depletion assessed by flow cytometry, changes...
<h3>Background</h3> Dose optimization, such as dose reduction or spacing, is nowadays presented a therapeutic strategy to be followed in patients with rheumatoid arthritis (RA) who have managed reach and maintain clinical remission for while. This reduces the frequency of adverse effects promotes cost savings <h3>Methods</h3> Patients RA (Criteria ACR 1987) CREATE registry (patients was treated real life conditions) had (DAS28 <2.6) at least 6 months duration on November 1, 2013,...
<h3>Background</h3> Circulating monocytes play a key role in the pathogenesis of cardiovascular disease (CVD). Three monocyte subsets have been described based on their CD14 and CD16 expression profiles, with different actions vascular pathology. The distribution these inflammatory profile associated CVD rheumatoid arthritis (RA) remain unknown. <h3>Objectives</h3> This study, developed within Innovative Medicines Initiative Joint Undertaking (IMI JU) project PRECISESADS framework, aimed at:...
<h3>Background</h3> Treatment with B-cell depletion, including rituximab (RTX), has been proven successful in achieving remission from the active disease Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) patients. However, effect of RTX on Cardiovascular (CVD) associated to both autoimmune conditions not elucidated yet. The aim this study was investigate whether depletion therapy an impact activation non-B cells immune vascular systems context CVD RA SLE patients...
<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory disease for which the etiopathogenesis has not yet been fully clarified. Splicing post-transcriptional process involved in RNA maturation. Recent studies have revealed that pathological deregulation of spliceosome associated to several human diseases. Yet, alterations and their modulation therapeutic response described AS <h3>Objectives</h3> 1) To evaluate potential leukocytes involvement pathophysiology. 2) analyse...
<h3>Objectives</h3> This study, developed within the IMI-JU project PRECISESADS framework, aimed to determine enrichment on CD14 +and CD16+monocyte subpopulations in SLE, APS and +SLE patients, investigate their role pathogenesis of these diseases. <h3>Methods</h3> The frequencies monocyte peripheral blood 54 healthy donors 46 SLE patients included study (preliminary data) were determined by flow cytometry. A second cohort 21 a third 19 included. Clinical profile, proinflammatory circulating...
<h3>Background</h3> Circulating miRNAs have been proposed as attractive candidates both diagnostic and prognostic biomarkers in various diseases, including a spectrum of autoimmune cardiovascular conditions. Yet, the contribution circulating to pathogenesis Rheumatoid Arthitis (RA) patients their potential role are still unknown. <h3>Objectives</h3> To identify disease features (CV) risk RA. <h3>Methods</h3> Plasma samples 48 healthy donors (HDs) 124 RA were collected. In discovery phase, an...
Abstract Background Atrial fibrillation (AF) is a widespread cause of prothrombotic state leading to long-term anticoagulant therapy. Literature describes coagulopathy as key pathogenic mechanism COVID-19 disease. Thus, antithrombotic therapy management still therapeutic challenge. During hospitalization, changing oral (OAC) therapies into subcutaneous heparin common in daily clinical practice. Purpose The primary endpoint this study analyze the impact AF mortality within 30 day since...
Abstract Background Recent studies suggest a higher mortality rate because of COVID-19 in patients with previous cardiac conditions compared to those without. Given the limited resources intensive care units (ICU) during pandemic outbreak, this fact has important implications. Purpose The main purpose study was compare 30-day infection and without conditions. secondary end point assess differences clinical severity (as development Acute Respiratory Distress Syndrome – ARDS) ICU admission...