A5028203693- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders Research
- Dermatologic Treatments and Research
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Toxin Mechanisms and Immunotoxins
- Systemic Lupus Erythematosus Research
- Connective Tissue Growth Factor Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Muscle and Compartmental Disorders
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
- Pulmonary Hypertension Research and Treatments
- Mast cells and histamine
- Inflammatory Bowel Disease
- Clinical practice guidelines implementation
- Heterotopic Ossification and Related Conditions
- Peripheral Neuropathies and Disorders
Hospital Universitario 12 De Octubre
2016-2025
Universidad Complutense de Madrid
2017-2024
Research Institute Hospital 12 de Octubre
2005-2023
University of Padua
2022
PharmacoGenetics (China)
2014
Hospital Universitario Fundación Jiménez Díaz
2013
St Thomas' Hospital
2002
Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 2011, we examined certificates all French patients with SSc to death. Then developed a score associated all-cause mortality from international European Scleroderma Trials Research (EUSTAR) database. Candidate prognostic were tested by Cox proportional hazards regression model single variable analysis, followed multiple stratified centres. The bootstrapping technique was used for...
Objective To determine mortality and causes of death in a multinational inception cohort subjects with systemic sclerosis (SSc). Methods We quantified as standardized ratio (SMR), years life lost, percentage the first decade disease. The comprised recruited within 4 disease onset. For comparison, we used prevalent cohort, which included all irrespective duration at recruitment. determined single primary cause (SSc related or non–SSc related) using case report form, evaluated predictors...
Abstract Background Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue (CTD), named overlap (OM). The question whether OM is distinct entity still remains controversial. Aim present study was conducted to assess the clinical and prognostic differences between patients diagnosed OM, primary polymyositis (PM) dermatomyositis (DM). Method consists retrospective longitudinal multicenter series...
Objectives We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response Fc-containing inhibitors of tumor necrosis factor (TNF). Methods A total 429 biologic-naive patients rheumatoid arthritis collected two sets (299 and 130) were treated during standard care infliximab (INX), etanercept, or adalimumab. Response was evaluated at 3, 6, 12 months follow-up as change Disease Activity Score (DAS) 28 from baseline by European League Against Rheumatism...
Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it frequently overlooked, as many patients are asymptomatic. The possibility of finding clinical clue predicting would help clinicians establish an early diagnosis PsA.A prospective single-center study total 90 with psoriasis was conducted to assess the presence entheseal abnormalities detected by ultrasound, and determine any correlation nail involvement.Entheseal were found in 23...
To examine genetic association between rheumatoid arthritis (RA) and known polymorphisms in core genes of the nuclear factor (NF)kappaB pathway, major intracellular pathway RA pathogenesis.Discovery replication sample sets Spanish patients with controls were studied. A total 181 single nucleotide (SNPs) uniformly spaced along genomic sequences 17 NFkappaB (REL, RELA, RELB, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, IKBKA, IKBKB, IKBKE, IKBKAP, KBRAS1, KBRAS2, MAP3K1, MAP3K14, TAX1BP1) studied by...
Upadacitinib has demonstrated efficacy in psoriatic arthritis clinical trials, but its real-world performance difficult-to-treat PsA remains underexplored. This observational, multicenter, open-label study evaluated the and safety of upadacitinib 134 patients with (97 women, mean age 51.8 ± 11.2 years, disease duration 9.94 7.72 years) who showed inadequate response to advanced therapies. Most (74.6%) had received at least two biological/targeted synthetic disease-modifying antirheumatic...
Ixekizumab (IXE) is an IgG4-type monoclonal antibody targeting IL-17A indicated alone or in combination with methotrexate, for the treatment of active psoriatic arthritis (PsA) adult patients insufficient response intolerance to one more disease-modifying anti-rheumatic drug (DMARD) therapy. The PRO-STIP study aimed describe persistence, patient characteristics, patterns, and effectiveness PsA receiving IXE a real-world clinical setting Spain. This was observational, multicentric,...