Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain.

• DOI: 10.14670/hh-23.433
• Publication Date: 2008-04-01
• Authors: Luigi Fabrizio Ro...; Francesca Ricci; Elisa Borsani; Alessandra Stacch...; Eleonora Foglio; Gaia Favero; Rita Rezzani; C. Mariani; Rossella Bianchi
• Keywords: Amyloid beta; Amyloid (mycology); Pathogenesis; Angiopathy

Aluminium (Al) is a neurotoxic metal and Al exposure may be factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings AD brain are presence neuritic plaques containing beta-amyloid (Abeta) which interfere with neuronal communication. Moreover, it has been observed that GRP78, stress-response protein induced by conditions adversely affect endoplasmic reticulum (ER) function, reduced patients. In this study, we investigated correlation between expression Abeta GRP78 cortex mice chronically treated aluminium sulphate. Chronic over 12 months to sulphate drinking water resulted deposition similar seen congophilic amyloid angiopathy (CAA) humans reduction what previously disease. So, hypothesise chronic administration responsible for oxidative cell damage interferes ER functions inducing accumulation damage.