A5062147159- Lymphatic Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Lymphatic System and Diseases
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Parvovirus B19 Infection Studies
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Viral Infections and Immunology Research
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations and Hemangiomas
- Ultrasound in Clinical Applications
- Gastrointestinal disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Childhood Cancer Survivors' Quality of Life
- Respiratory viral infections research
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- COVID-19 and healthcare impacts
- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- Vestibular and auditory disorders
- Genomics and Rare Diseases
- Injury Epidemiology and Prevention
- COVID-19 Impact on Reproduction
Istituto Giannina Gaslini
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2025
University of Genoa
2011-2025
University of Arizona
2020
University of North Texas
2020
University of North Texas Health Science Center
2020
Hydrops fetalis is an excessive fluid accumulation within the fetal extra vascular compartments and body cavities. Non-immune hydrops (NIHF), due to causes other than Rh alloimmunization, cause in >85% of all affected individuals. Herein we present update our earlier systematic literature review [Bellini et al., 2009] using publications between 2007 2013. We excluded most initial 31,783 papers by strict selection criteria, thus resulting 24 relevant NIHF describing 1,338 individuals with...
Quarantine and isolation measures during COVID-19 pandemic may have caused additional stress challenged the mental health of youth. Aim study is to investigate impact on neuropsychological disorders (NPD) Italian children adolescents provide general pediatric recommendations.A retrospective multicenter observational was planned by Pediatric Society (SIP) explore access Emergency Departments (pED) for evaluation symptoms, collecting classification codes diagnoses between March 1, 2019 2,...
Intestinal failure (IF) is the reduction in functioning gut mass below minimal level necessary for adequate digestion and absorption of nutrients fluids weight maintenance adults or growth children. There a paucity epidemiologic data on pediatric IF. The purpose this study was to determine prevalence, incidence, regional distribution underlying diagnosis chronic IF (CIF) requiring home parenteral nutrition (HPN) Italy.Local investigators were selected 19 Italian centers either reference HPN...
Abstract Pediatric drowning incidents, both fatal and non-fatal, represent a significant challenge in emergency medicine, particularly for children under 14 years of age. Drowning is leading cause unintentional injury-related deaths, with aged one to four being especially vulnerable. Accurate timely assessment, through chest imaging, such as radiography (CXR) lung point-of-care ultrasound (LUS), crucial evaluating pulmonary complications guiding treatment decisions. This retrospective study...
Background: Although home births provide personal and intimate experiences, they pose potential risks that may be better managed in hospital settings. The safety of birth remains highly debated, with no consensus on its or adverse events, adoption varies widely across the world. In Italy, Italian Society Neonatology opposed this practice, resulting one lowest rates Europe (approximately 0.1% total births). This study evaluated impact planned neonatal health, a focus severe complications...
Background/Objectives: Meropenem is a broad-spectrum antibiotic essential for treating resistant Gram-negative infections in pediatric patients. Current dosing recommendations may not consistently achieve optimal pharmacokinetic (PK) targets, especially critically ill children. Methods: We conducted retrospective cohort study at IRCCS Istituto Giannina Gaslini, analyzing 97 plasma levels from 86 patients (<18 years) hospitalized between January 2020 and December 2023 the neonatal...
The author declares no conflict of interest. Data sharing not applicable to this article as datasets were generated or analysed during the current study.
Vein line positioning represents one of the first diagnostic and therapeutic steps in Pediatric Emergency Department (PED); however, outcome this maneuver is frequently not as expected, especially for difficult-to-access (DIVA) patients. The standard technique (visual-palpatory) has a low success rate; hence ultrasound (US) assistance been suggested DIVA patients, although controversial results have obtained. Our study compared rate an intravascular (IV) access procedure at attempt, with...
We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency (NT) between 11(+0) and 13(+6) weeks' gestation. The aim this study was to assess corresponding NT anatomic features by immunohistochemical (IHC) investigation. A morphological performed using lymphatic blood endothelial specific markers, as well smooth muscle actin (SMA). found all cases were D2-40 positive, CD31 CD34 negative, suggesting presence lymph vessel ectasia. 12/18 SMA staining...
Background Nance‐Horan syndrome (NHS) is a rare X‐linked developmental disorder characterized by congenital cataract, dental anomalies and facial dysmorphisms. Notably, up to 30% of NHS patients have intellectual disability few been reported cardiac defects. caused mutations in the gene that highly expressed midbrain, retina, lens, tooth, conserved across vertebrate species. Although most pathogenic are nonsense mutations, genomic rearrangements involving locus reported, suggesting possible...
Abstract Backgrounds Dehydration is among the most common causes of Pediatric Emergency Department admission; however, no clinical signs, symptoms, or biomarkers have demonstrated sufficient sensitivity, specificity, reliability to predict dehydration. Methods We conducted a prospective, monocentric, observational study at Giannina Gaslini Hospital, tertiary care pediatric hospital. Our aimed compare inferior vena cava ultrasound measurement with volume depletion understand if point-of-care...
Abstract The objective of our study was to evaluate the usefulness immunohistochemical (IHC) staining techniques in etiological diagnosis non‐immune hydrops fetalis (NIHF). records all 1,098 autopsies performed between January 1987 and May 2008, by Division Fetal Pathology University Genoa, were reviewed 79 fetuses diagnosed with NIHF re‐evaluated. Additional IHC using antibodies that specifically stain blood lymph vessels (CD31, CD34, smooth muscle actin antibody, D2‐40) performed. Results...
Allergic colitis shows overlap with classic inflammatory bowel disease (IBD). Clinically, allergic is associated dysmotility and abdominal pain, mucosal eosinophilia characteristic. We thus aimed to characterise changes in children compared normal tissue IBD, focusing on potential interaction between eosinophils mast cells enteric neurones.A total of 15 colitis, 10 Crohn (CD), ulcerative (UC), histologically controls were studied. Mucosal biopsies stained for CD3 T cells, Ki-67, eotaxin-1,...
Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening disease temporally linked to SARS-CoV-2 whose incidence and clinical presentation may have been altered by the different variants vaccination.
Congenital chylothorax is an uncommon condition but represents the main cause of congenital pleural effusion during neonatal period. It usually appears before birth, both as isolated disorder or in association with hydrops fetalis, negatively affecting subsequent outcome. Prenatal treatment considered to ensure a satisfactory lung development case moderate severe presence hydrops, although consensus on timing and modalities has not been reached date. Both medical surgical therapeutic...
Although children seem to be less affected than adults by COVID-19, Italian paediatric hospitals have had significantly reorganise services deal with the pandemic. These include tertiary-level Gaslini Children's Hospital in Genoa, which handles around 35,000 emergency room (ER) visits per year. The Government lockdown has dramatically reduced ER admissions and delayed programmed admissions.1 We noticed this from first verified cases of COVID-19 Italy, visit fell after schools closed our...