Francesca Trespidi
A5092232269- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Genetic and Kidney Cyst Diseases
- Neonatal Respiratory Health Research
- Complement system in diseases
- Congenital Diaphragmatic Hernia Studies
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Medical Imaging and Pathology Studies
Policlinico San Matteo Fondazione
2023-2025
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis <1% of infected individuals. We show that ∼35% patients hospitalized for WNV disease (WNVD) six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence these antibodies highest with (∼40%), silent as low general population. odds ratios WNVD relative to those without them population range 19.0 (95% CI 15.0–24.0, P value <10–15) only...
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif 2 (CCR2). Nine children from five independent kindreds have pulmonary alveolar proteinosis (PAP), progressive polycystic disease, and recurrent infections, including bacillus Calmette Guérin (BCG) disease. The CCR2 variants are homozygous in six patients compound heterozygous three, all loss-of-expression loss-of-function. They abolish CCR2-agonist ligand...
Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne (TBE, TBE [TBEV]) (∼10%). We report here that these auto-Abs also severe forms rarer arboviral infections. Auto-Abs high concentrations IFN-α2, IFN-β, and/or IFN-ω present in the single case Powassan (POWV) studied, two three cases Usutu (USUV) infection most 24 Ross River...
Auto-antibodies (auto-Abs) that neutralize type I interferons (IFNs) have been implicated in severe viral infections, including ~ 40% of cases West Nile virus (WNV) neuroinvasive disease (WNND). Developing robust vitro models to evaluate the protective effects IFNs against infection, as well disruptive auto-Abs, is essential for understanding pathogenesis and identifying patients at risk. In this study, we used Vero E6 ARPE-19 cell lines investigate ability (IFN-α, IFN-β, IFN-ω), II (IFN-γ),...