A5016769431- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- MRI in cancer diagnosis
- Inflammatory mediators and NSAID effects
- Acute Kidney Injury Research
- Food Quality and Safety Studies
- Neurological Complications and Syndromes
- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Vector-Borne Animal Diseases
- Healthcare and Venom Research
- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Genetic and Kidney Cyst Diseases
- Pesticide Residue Analysis and Safety
- Vector-borne infectious diseases
- Dialysis and Renal Disease Management
- Enterobacteriaceae and Cronobacter Research
- Radiomics and Machine Learning in Medical Imaging
- Parasitic Diseases Research and Treatment
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Parasitic Infections and Diagnostics
- Complement system in diseases
Medizinische Hochschule Hannover
2014-2024
German Center for Lung Research
2020
Chosun University
2010-2018
Chonnam National University
2015
Gwangju Health University
2012-2013
University of California, Berkeley
1977
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif 2 (CCR2). Nine children from five independent kindreds have pulmonary alveolar proteinosis (PAP), progressive polycystic disease, and recurrent infections, including bacillus Calmette Guérin (BCG) disease. The CCR2 variants are homozygous in six patients compound heterozygous three, all loss-of-expression loss-of-function. They abolish CCR2-agonist ligand...
Background Macrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid malignancies makes them promising targets for the chimeric antigen receptor (CAR) technology redirect their stage polarization, thus enhancing anticancer capacities. Given emerging interest CAR-macrophages, generation such cells so far mainly depends on peripheral blood monocytes, which are isolated from respective donor prior genetic...
This article reports the findings of a 20-year study children from lower-class multiproblem urban families, some whose parents were alcoholics. The found that although parents' alcoholism increased problems these already troubled and likelihood they would grow up to have drinking problems, it is not possible predict child's future adjustment solely alcoholism.
Objectives The aims of this experimental study were to investigate renal allograft pathophysiology by multiparametric functional magnetic resonance imaging (MRI) and directly correlate MRI parameters with histopathology in mouse models allogenic isogenic kidney transplantation (ktx). Materials Methods Allograft rejection was induced C57BL/6 (B6) donor kidneys into BALB/c recipients (allogenic ktx). B6 mice that received served as controls (isogenic Three weeks after ktx, performed using a...
Delayed graft function (DGF) after kidney transplantation is not uncommon, and it associated with long-term allograft impairment. Our aim was to compare renal perfusion changes measured noninvasive functional MRI in patients early histology biopsy samples. Forty-six underwent 4–11 days transplantation. Contrast-free images were acquired using an arterial spin labeling technique. Renal assessed by estimated glomerular filtration rate (eGFR), biopsies performed when indicated within 5 of MRI....
Purpose The purpose was to characterize acute kidney injury (AKI) in C57BL/6 (B6)- and 129/Sv (Sv)-mice by noninvasive measurement of renal perfusion tissue edema using functional MRI. Methods Different severities AKI were induced B6- Sv-mice ischemia reperfusion (IRI). Unilateral clamping the pedicle for 35 min (moderate AKI) or 45 (severe done. MRI (7-Tesla) performed 1, 7 28 days after surgery a flow alternating inversion recovery (FAIR) arterial spin labeling (ASL) sequence. Maps...
This study was conducted to determine which genotypes were present in southwestern Korea. Nested polymerase chain reaction (PCR) and DNA sequence analysis targeting the Orientia tsutsugamushi-specific 56-kDa protein gene performed with samples of blood eschar. Of 69 PCR-positive samples, 61 clustered Boryong previously isolated CUH 4-6 had homology 100% Kato, 4-3 99.8% Kato formed cluster. 4-57, 4-31, 4-142, 4-324 a Kawasaki 4-271 Jecheon Karp 4-117 Neimeng-65, Gilliam The most common...
Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantion. The length of warm ischemia time is critical for the extent tissue damage renal IRI. In this experimental study we hypothesized that local release labile heme triggered by duration (15 versus 45 min IRI) and mediates complement activation, cytokine inflammation. Methods: To induce IRI, pedicle clamping was performed male C57BL/6 mice short min) or prolonged (45 periods. Two 24 h after levels kidney...
Epidemiologic studies show a correlation between the dietary intake of food polyphenols and beneficial health effects. Several in vitro indicate that anti-inflammatory potential is, at least part, mediated by modulation enzymes arachidonic acid cascade, such as prostaglandin forming cyclooxygenases (COXs). Evidence this mode action can be transferred to situation vivo is scarce. This study characterized effects subset on COX–2 expression activity compared potency with known drugs. Next,...
Kidney transplantation (ktx) in mice is used to learn about rejection and develop new treatment strategies. Past studies have mainly been based on histological or molecular biological methods. Imaging techniques monitor allograft pathology rarely used.Here we investigated after isogenic allogenic ktx over time with functional MRI diffusion-weighted imaging (DWI) mapping of T2-relaxation (T2-mapping) assess graft inflammation edema formation. To characterize pathology, PAS-staining, counted...
Renal ischemia-reperfusion injury (IRI) is a severe complication of major surgery and risk factor for increased morbidity mortality. Here, we investigated mechanisms that might contribute to IRI-induced progression chronic kidney disease (CKD). Acute (AKI) was induced by unilateral IRI 35 min in CD1 C57BL/6 (B6) mice. Unilateral used overcome early morphology, NGAL upregulation, neutrophil infiltration as well peritubular capillary density were studied immunohistochemistry. The composition...
Rice prolamin has been reported to possess antioxidative, anti-inflammatory and immune-promoting properties. This study is aimed examine the protective effects of dietary rice extract (RPE) against dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice.BALB/c mice were fed diet supplemented with 0-0.1 % RPE for 6 weeks. For last 2 weeks, 1 or 0.2 DNCB was applied repeatedly back induce AD-like lesions. Following AD induction, severity examined macroscopically...
Ischemia reperfusion injury (IRI) is linked with inflammation in kidney transplantation (ktx). The chemokine CXCL13, also known as B lymphocyte chemoattractant, mediates recruitment of cells within follicles lymphoid tissues and has recently been identified a biomarker for acute allograft rejection. goal this study was to explore whether IRI contributes the up-regulation CXCL13 levels ktx. It demonstrated that systemic were increased mouse models uni- bilateral renal IRI, which correlated...
Abstract Background There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells various applications drug screening and/or cell therapy. However, the application of these cultivating hiPSC-derived immune other blood noticeably lacking. To address this gap, we have developed xeno-free chemically defined bioreactor platform, which allows generation standardized human iPSC-derived hematopoietic organoids subsequent continuous...
Doxycycline is currently the most frequently used treatment in patients with scrub typhus. However, doxycycline-resistant strains have been found, necessitating development of a new treatment. Rifampin known to be effective even for such strains. Our aim this study was compare effects rifampin and doxycycline typhus areas which resistance has not reported.Patients admitted Chosun University Hospital regional network hospitals between 2007 2009 body temperature ≥37.5°C suspected were randomly...
Nephrotoxic drugs can cause acute kidney injury (AKI) and analgesic nephropathy. Diclofenac is potentially nephrotoxic frequently prescribed for pain control. In this study, we investigated the effects of single repetitive oral doses diclofenac in setting pre-existing subclinical AKI on further course long-term renal consequences. Unilateral ischemia–reperfusion (IRI) 15 min was performed male CD1 mice to induce AKI. Immediately after surgery, (100 mg or 200 mg) were administered. a separate...
IL-17A contributes to acute kidney injury and fibrosis. Therefore, we asked whether deficiency or treatment with a blocking antibody impacts severe renal ischaemia reperfusion (IRI) the progression chronic disease (CKD).IL-17A-deficient wild-type (WT) mice underwent transient unilateral pedicle clamping for 45 min induce IRI subsequent Furthermore, neutralizing anti-IL-17A (mAb) was injected into WT before induction of intravenously. On days 1, 7 21, inflammation, fibrosis, leukocyte...
Acute kidney injury (AKI) frequently complicates major surgery and can be associated with hypertension progress to chronic disease, but reports on blood pressure normalization in AKI are conflicting. In the present study, we investigated effects of an angiotensin-converting enzyme inhibitor, enalapril, a soluble epoxide hydrolase 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), renal inflammation, fibrosis, glomerulosclerosis mouse model ischemia-reperfusion (IRI)-induced...
The clinical significance of the Enterobacter nimipressuralis as human pathogens remains unclear. microbiologic culture monitoring system sterile body fluids revealed on an episode cloacae and amnigenus in blood results same day; antibiotic sensitivity MIC were nearly for both species. First patient was a healthy woman with postmenopausal syndrome, while second herpes zoster. Both patients had febrile sensations without signs bacteremia. E. also cultured from unused package salined cotton...
Smoking in adolescence can cause other health risks such as drinking and abusing drugs. Besides, it goes on adulthood so threaten their all days. This study want to know the relationship between smoking internet addiction mid- highschool students Korea. It conducted for 38,409 middle school 36,657 student was investigated by chi-squared test relation them done a Logistic Regression Analysis. The statistical significance is under 0.05. percentage of 34.2% male 19.7% female student. 17.6%...
Identification of mite and tick bite sites provides important clinical information. The predominant species in Korea associated with scrub typhus are Leptotrombidium pallidum scutellare . most abundant is Haemaphysalis longicornis To date, there has been no comparative study on preferred between mites ticks humans. This included a review medical records field study. For sites, eschars were checked 506 patients typhus, confirmed by indirect immunofluorescence assay or nested polymerase chain...
Objectives Heart transplantation (HTX) in mice is used to characterize gene-deficient and test new treatment strategies. The purpose was establish noninvasive magnetic resonance imaging techniques monitor pathophysiological changes of the allograft during rejection. Materials Methods Magnetic performed at baseline days 1 6 after isogenic (n = 10, C57BL/6) allogenic 12, C57BL/6 BALB/c) heterotopic HTX on a 7 T small animal scanner. Respiratory- electrocardiogram-gated multislice multi-echo...