A5100321802- TGF-β signaling in diseases
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Skin Protection and Aging
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Contact Dermatitis and Allergies
- Prostate Cancer Treatment and Research
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Advancements in Transdermal Drug Delivery
- Eosinophilic Disorders and Syndromes
- Bone Metabolism and Diseases
- Drug-Induced Adverse Reactions
- Sarcoma Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Cancer-related gene regulation
- Hair Growth and Disorders
- Allergic Rhinitis and Sensitization
- Nonmelanoma Skin Cancer Studies
- NF-κB Signaling Pathways
- Genetic and rare skin diseases.
Boditech Med (South Korea)
2019-2024
Hallym University Sacred Heart Hospital
2024
University of Ulsan
2020-2024
Asan Medical Center
2024
Ulsan College
2024
Chonnam National University Hospital
2013-2023
Case Western Reserve University
2007-2023
Chonnam National University
2009-2023
Rainbow Babies & Children's Hospital
2008-2023
Wonkwang University
2021-2023
Pancreatic islet beta-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis. Consequently, knowledge signals that regulate function immense clinical relevance. Transforming growth factor (TGF)-beta signaling plays critical role in pancreatic development although the this pathway adult pancreas obscure. Here, we define an important TGF-beta regulation insulin gene transcription and function. We identify as target show effector Smad3 occupies promoter represses transcription....
Androgenetic alopecia (AGA) is a common hair loss disease with genetic predisposition among men and women, it may commence at any age after puberty. It significantly affect variety of psychological social aspects one's life the individual's overall quality (QoL).This study aimed to investigate QoL AGA patients discover factors that can influence patients, including previous experience in non-medical care, reasons for hospital visits, age, duration, severity AGA.A total 998 male were...
Owing to its tumor tropism and prolonged transgene expression, mesenchymal stem cell (MSC) has been considered as an ideal delivery vehicle for cancer gene therapies or therapeutic vaccines. In this study, we demonstrated that intratumoral (i.t.) injection of MSCs expressing modified interleukin-12 (MSCs/IL-12M) exhibited stronger tumor-specific T-cell responses antitumor effects well more sustained expressions IL-12 interferon (IFN)-γ in both sera sites than did IL-12M-expressing adenovirus...
Suppression of glycogen synthase kinase 3 (GSK3) activity in neurons yields pleiotropic outcomes, causing both axon growth promotion and inhibition. Previous studies have suggested that specific GSK3 substrates, such as adenomatous polyposis coli (APC) collapsin response mediator protein 2 (CRMP2), support by regulating the stability axonal microtubules (MTs), but substrate(s) mechanisms conveying inhibition remain elusive. Here we show CLIP (cytoplasmic linker protein)-associated (CLASP),...
Collagenase production by synovial fibroblast-like cells (synoviocytes) plays a major role in cartilage and bone destruction rheumatoid arthritis. Interleukin-1 (IL-1) increases collagenase secretion elevating the steady state levels of mRNA cultured synoviocytes, while all-trans-retinoic acid (RA) has opposite effect. We have studied regulation gene transcription IL-1 RA synoviocytes transient transfection plasmid constructs containing deletion mutants 5'-flanking region or isolated phorbol...
The main physiologically active polyphenol in green tea extract is (-)-epigallocatechin gallate (EGCG). Green has an advantage over EGCG as a cancer chemopreventive agent for humans, apparent from the Japanese custom of injesting on daily basis. similarly inhibited protein kinase C activation by teleocidin, tumor promoter, did EGCG. In addition, and showed inhibitory effects growth lung mammary cell lines with similar potencies. An experiment using estrogen-dependent MCF-7 line mechanisms...
Growth factor-independent 32D-src and 32D-abl cell lines, established by infecting the interleukin-3-dependent myeloid precursor line (32D-123) with retroviruses containing src or abl oncogene, were used to study transcriptional regulation of transforming growth factor beta 1 (TGF-beta 1) mRNA. Analysis different TGF-beta promoter constructs regulated pp60v-src indicated that sequences responsive high levels induction contain binding sites for AP-1. Both serum induced expression c-fos c-jun...
Autoimmune encephalomyelitis, a mouse model for multiple sclerosis, is characterized by the activation of immune cells, demyelination axons in CNS, and paralysis. We found that TGF-β1 synthesis glial cells TGF-β–induced signaling CNS were activated several days before onset paralysis mice with autoimmune encephalomyelitis. While early production was observed TGF-β neurons later infiltrating T inflammatory lesions. Systemic treatment pharmacological inhibitor ameliorated paralytic disease...
N-linked glycosylation is a critical determinant of protein structure and function, regulating processes such as folding, stability localization, ligand–receptor binding intracellular signalling. TβRII [type II TGF-β (transforming growth factor β) receptor] plays crucial role in the signalling pathway. Although was first demonstrated over decade ago, it unclear how this modification influenced biology. In present study, we show that inhibiting process successfully hinders TGF-β1 to...
Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative breast cancer) has limited treatment options and still lacks viable molecular targets, leading to poor outcomes. Recently, RNA-binding proteins (RBPs) have been shown play crucial roles human cancers, including BC, by modulating a number oncogenic phenotypes. This suggests that RBPs represent potential targets for BC therapy. Methods: We employed genomic data identify specifically expressed TNBC. NONO was...
Diminished cellular responsiveness to transforming growth factor-β (TGF-β) is frequently correlated with decreased transcription of the type II receptor for TGF-β (TGF-β RII). We have cloned and characterized human RII promoter and, using S1 nuclease mapping 5′ rapid amplification cDNA ends polymerase chain reaction, identified five alternative start sites within region -33 +57. DNA transfection experiments electrophoretic mobility shift assays revealed existence distinct regulatory regions...
A 2.5-kilobase cDNA clone that encodes a 371-amino acid novel transcription factor was isolated from human placenta library using yeast one-hybrid system. The novel<i>ets</i>-<i>r</i>elated <i>t</i>ranscription (ERT) showed homology with the ETS DNA-binding domain. Using constructs of transforming growth factor-β (TGF-β) type II receptor (RII) promoter linked to luciferase gene, we have demonstrated ERT activates TGF-β RII gene through 5′-TTTCCTGTTTCC-3′ response element spanning nucleotides...
Transforming growth factor β (TGF-β) has been proposed to play a number of roles in central nervous system (CNS) development and response injury. To test these proposals, transgenic mice were generated which overproduce TGF-β1 the CNS. Surprisingly, developed severe hydrocephalus died between birth 3 weeks age. Ovary transplantation from an affected female founder permitted perpetuation one lines as model whose genetic defect is known. These results also demonstrate that developing CNS...
Although rosacea is a chronic cutaneous inflammatory disorder that's commonly seen in adults, the etiology and pathogenesis of illness remain unclear. A well established diagnostic classification grading system may play critical role performing research it would serve as reference clinical field. We sought to classify patients with new standard we wanted determine peculiar features relationships each subtype. also analyzed between degree sun exposure reviewed medical records photos 168 who...
Tropomyosin-related kinase (Trk) C, a member of the Trk family neurotrophin receptors, has been implicated in growth and survival human cancer tissues. Here, we report that TrkC is frequently overexpressed breast cancers plays an essential role tumor metastasis. Ectopic expression non-malignant mammary epithelial cells suppressed anoikis, which correlated with activation Ras-mitogen-activated protein phosphatidylinositol-3-OH (PI3K)/Akt pathways, reduced metastatic regulator Twist....