A5100318799- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Iron Metabolism and Disorders
- Frailty in Older Adults
- Erythropoietin and Anemia Treatment
- Mitochondrial Function and Pathology
- Gastric Cancer Management and Outcomes
- Organ Donation and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Kyungpook National University
2016-2025
CHA Bundang Medical Center
2015-2024
CHA University
2012-2024
Keimyung University
2011-2024
Keimyung University Dongsan Medical Center
2011-2024
Eulji University Hospital
2024
Brigham and Women's Hospital
2024
Harvard University
2024
Eulji University
2011-2024
Asan Medical Center
2011-2024
We examined the effects of empagliflozin, a selective inhibitor Na+-glucose cotransporter 2, on mitochondrial quality control and autophagy in renal tubular cells diabetic environment vivo vitro. Human proximal (hRPTCs) were incubated under high-glucose conditions. Diabetes was induced with streptozotocin male C57BL/6J mice. Improvements biogenesis balanced fusion-fission protein expression noted hRPTCs after treatment empagliflozin media. Empagliflozin also increased autophagic activities...
Functional and structural abnormalities in the renal microvasculature are important processes contributing to pathophysiology of ischemic acute kidney injury (AKI). In this study, we examine contribution endothelial cell loss via apoptosis on microvascular permeability rarefaction a mouse model AKI. Three-dimensional reconstructions networks obtained 24 h following demonstrate an intact monolayer areas increased permeability. A 45% decrease density was observed 4 wk after injury. Examination...
ObjectiveTo investigate the clinical implications of frailty in chronic kidney disease patients undergoing maintenance hemodialysis and peritoneal dialysis.DesignIn this prospective study, all participants completed Short Form Kidney Disease Quality Life questionnaire, Korean version, to determine their phenotype. We also obtained blood chemistry demographic data at enrollment. Data regarding history hospitalization death were collected during follow-up period.SubjectsWe recruited 1,658...
Sepsis is the most common cause of acute kidney injury in critically ill patients; however, mechanisms leading to sepsis remain elusive. Although has been considered an excessive systemic inflammatory response, clinical trials that inhibit inflammation have shown no effect. The purpose this study was examine pathophysiology septic focusing on immune responses and renal tubular cell apoptosis by providing on-site quantitative comparison between septic- ischemia/reperfusion-induced...
N-linked glycosylation is a critical determinant of protein structure and function, regulating processes such as folding, stability localization, ligand–receptor binding intracellular signalling. TβRII [type II TGF-β (transforming growth factor β) receptor] plays crucial role in the signalling pathway. Although was first demonstrated over decade ago, it unclear how this modification influenced biology. In present study, we show that inhibiting process successfully hinders TGF-β1 to...
Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, two most commonly used methods assessing performance. obtained data regarding strength from 277 evaluated their relationships baseline parameters, mental health, plasma inflammatory markers, major adverse outcomes. was defined by recommendations suggested Asian Working Group on Sarcopenia. The prevalence...
Health-related quality of life (HRQoL) surveys are needed to evaluate regional and ethnic specificies. The aim the present study was differences in HRQoL, frailty, disability according dialysis modality Korean population.We enrolled relatively stable maintenance patients. A total 1,616 patients were recruited into our study. demographic laboratory data collected at enrollment included age, sex, comorbidities, disability, HRQoL scales.A 1,250 366 participants underwent hemodialysis (HD)...
Abstract An endomicroscope opens new frontiers of non-invasive biopsy for in vivo imaging applications. Here we report two-photon laser scanning cellular and tissue using a Lissajous fiber scanner. The scanner consists piezoelectric (PZT) tube, single double-clad (DCF) with high fluorescence collection, micro-tethered-silicon-oscillator (MTSO) the separation biaxial resonant frequencies. endomicroscopic exhibits 5 frames/s 99% density by selection rule was compactly packaged within stainless...
Abstract We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Oral administration of C3G reduced hepatic plasma triglyceride levels, adiposity, improved glucose tolerance in mice fed high-fat diet. Hepatic metabolomic analysis revealed that shifted metabolite profiles towards fatty acid oxidation ketogenesis. increased uptake HepG2 cells C2C12 myotubes induced rate oxidation. directly interacted with activated PPARs,...
Mitochondrial dysfunction is considered to be an important mediator of the pro-aging process in chronic kidney disease, which continuously increasing worldwide. Although PTEN-induced kinase 1 (PINK1) regulates mitochondrial function, its role renal aging remains unclear. We investigated association between PINK1 and aging, especially through cGAS-STING pathway, known result inflammatory phenotype. Pink1 knockout (Pink1-/- ) C57BL/6 mice senescence-induced tubular epithelial cells (HKC-8)...
Microvascular rarefaction following an episode of acute kidney injury (AKI) is associated with renal hypoxia and progression toward chronic disease. The mechanisms contributing to microvascular are not well-understood, although disruption in local angioregulatory substances thought contribute. Matrix metalloproteinase (MMP)-9 endopeptidase important modifying the extracellular matrix (ECM) remodeling vasculature. We examined role MMP-9 gene deletion on a rodent model ischemic AKI. MMP-9-null...
Studying the effect of exposure or intervention on a dichotomous outcome is very common in medical research. Logistic regression (LR) often used to determine such association which provides odds ratio (OR). OR overestimates size for prevalent data. In situations, use relative risk (RR) has been suggested. We propose modifications Zhang and Yu Diaz-Quijano methods. These methods were compared with stratified Mantel Haenszel method, LR, log binomial (LBR), Poisson/Cox regression, modified...
Purpose. In this study, we investigated the effect of PGC1 α activators on mitochondrial fusion, fission, and autophagic quality control in renal tubular cells a diabetic environment vivo vitro. We also examined whether upregulation attenuates tubulopathy by normalizing homeostasis. Methods . HKC8 were subjected to high-glucose conditions (30 mM D-glucose). Diabetes was induced with streptozotocin (STZ, 50 mg/kg i.p. for 5 days) male C57/BL6J mice. AICAR or metformin used as activator....
Heavy proteinuria with or without features of nephrotic syndrome is associated many primary and systemic diseases. For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from nephropathy (DN) important in choosing treatment modalities determining prognosis. However, clinical relevance heavy inconsistent DN assessments. This study investigated the clinicopathological outcomes NDRD type 2 patients nephrotic-range proteinuria. We enrolled 220 cases who underwent biopsy. They...
Sepsis is one of the most common clinical syndromes that causes death and disability. Although many studies have developed drugs for sepsis treatment, none decreased mortality rate. The aim this study was to identify a novel treatment option using library integrated network-based cellular signatures (LINCS) L1000 perturbation dataset based on an in vitro vivo model. Sepsis-related microarray early-stage inflammatory processes patients innate immune cells were collected from Gene Expression...
The intratubular renin-angiotensin system (RAS) is thought to play an essential role in hypertensive renal disease, but information regarding sex-related differences this limited. present study investigated sex the RAS two-kidney, one-clip (2K1C) rats. A 2.5-mm clip was placed on left artery of Sprague-Dawley rats, and rats were euthanized 3 or 5 wk after operation. Systolic blood pressure increased 2K1C both sexes significantly higher male than female antihypertensive effect not observed...
Abstract Claudin-11, a member of claudins consisting tight junction has been shown to be associated with prognosis and play dual roles in cancer. However, its role the response anti-cancer agents is unknown. In this study, we investigated mechanism claudin-11 cisplatin resistance ovarian Kaplan-Meier survival analysis using The Cancer Genome Atlas data revealed that high CLDN11 expression significantly poor Claudin-11 was upregulated cisplatin-resistant cancer cells. Consistent this,...
Abstract Background/Aims: The present study aimed to assess the incidence of advanced cirrhotic complications and identify risk factors associated with such in chronic hepatitis C. Methods: data 1137 C patients were retrospectively reviewed. We analysed rate for ‘disease progression’, as defined by occurrence an increase at least 2 points Child–Pugh score, oesophageal/gastric variceal bleeding, spontaneous bacterial peritonitis, hepatic encephalopathy, death related liver disease or...
ERG, a member of the ETS family transcription factors, is highly specific endothelial marker. We investigated whether use ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.Fifteen cases surgically resected colorectal cancers with hepatic metastasis were selected most representative sections for detection immunostained CD31, D2-40. Eight independently evaluated status on hematoxylin eosin (H&E) corresponding...