A5009735001- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Sirtuins and Resveratrol in Medicine
- Metabolomics and Mass Spectrometry Studies
- Tea Polyphenols and Effects
- Antioxidant Activity and Oxidative Stress
- Phytoestrogen effects and research
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Plant Genetic and Mutation Studies
- Microbial Metabolism and Applications
- Biochemical Analysis and Sensing Techniques
- Exercise and Physiological Responses
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Plant tissue culture and regeneration
- Neurobiology and Insect Physiology Research
- Vitamin C and Antioxidants Research
- Histone Deacetylase Inhibitors Research
- Adipokines, Inflammation, and Metabolic Diseases
Australian Regenerative Medicine Institute
2021-2023
Monash University
2021-2023
Korea University
2011-2022
Scope A natural carotenoid abundant in seafood, astaxanthin ( AX ), has hypolipidemic activity, but its underlying mechanisms of action and protein targets are unknown. We investigated the molecular mechanism hepatic hyperlipidemia by measuring peroxisome proliferator‐activated receptors PPAR ) activity. Methods results examined binding to subtypes effects on lipid metabolism. activated ‐α, inhibited ‐γ transactivation activity reporter gene assay time‐resolved fluorescence energy transfer...
Olfactory receptors (ORs) are present in tissues outside the olfactory system; however, function of these remains relatively unknown. Here, we determined that receptor 544 (Olfr544) is highly expressed liver and adipose tissue mice regulates cellular energy metabolism obesity. Azelaic acid (AzA), an Olfr544 ligand, specifically induced PKA-dependent lipolysis adipocytes promoted fatty oxidation (FAO) ketogenesis liver, thus shifting fuel preference to fats. After 6 weeks administration, fed...
Reactive oxygen species (ROS) generated during exercise are considered integral for the health-promoting effects of exercise. However, precise mechanisms by which and ROS promote metabolic health remain unclear. Here, we demonstrate that skeletal muscle NADPH oxidase 4 (NOX4), is induced after exercise, facilitates ROS-mediated adaptive responses function, maintain redox balance, prevent development insulin resistance. Conversely, reductions in NOX4 aging obesity contribute to deletion...
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the majority of obese individuals, but a subset, this progresses to non-alcoholic steatohepatitis (NASH) and fibrosis. The mechanisms that prevent NASH fibrosis NAFLD patients remain unclear. Here we report NAD(P)H oxidase (NOX)-4 nuclear factor erythroid 2-related 2 (NFE2L2) were elevated hepatocytes early progression NASH/fibrosis. Mitochondrial-derived reactive oxygen species (ROS) activated NFE2L2 induce expression NOX4, which...
Abstract We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Oral administration of C3G reduced hepatic plasma triglyceride levels, adiposity, improved glucose tolerance in mice fed high-fat diet. Hepatic metabolomic analysis revealed that shifted metabolite profiles towards fatty acid oxidation ketogenesis. increased uptake HepG2 cells C2C12 myotubes induced rate oxidation. directly interacted with activated PPARs,...
Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin abundant in fruits and vegetables that interacts possibly modulates energy metabolism oxidative stress. This study investigated the effect of C3G on gluconeogenesis cancer cell senescence. activates adenosine monophosphate-activated protein kinase (AMPK), cellular sensor involved aging process. suppressed hepatic by reducing expression gluconeogenic genes through phosphorylation inactivation CRTC2 HDAC5 coactivators via AMPK. did not...
Meju, a naturally fermented soy block used to produce paste and sauce in Korea, is suggested exhibit hypolipidemic antiinflammatory activities; however, its mechanisms of action are elusive. Here, we report that the water-soluble fibers but not amino acids peptides from meju exhibited activity vivo. Feeding soybean (FSF) reduced plasma cholesterol, triglyceride, adipocyte size, hepatic lipid accumulation C57BL/6 J mice. FSF treatment HMG-CoA reductase expression, whereas expression genes...
The consumption of soy protein and fiber reduces body fat accumulation; however, the mechanism this effect has not been clearly understood. We investigated antiobesogenic in two different mouse models. Normolipidemic nonobese C57BL/6J hyperlipidemic obese human apolipoprotein E2 transgenic mice were fed either delipidated soybean (DLSB) containing or a control diet. DLSB-fed showed significant reduction weight gain adiposity compared with controls, both apoE2 mice. All metabolic parameters...
We examined the in vitro mutagenic and antimutagenic effects of hexane-extracted hemp (Cannabis sativa L. subsp. var. sativa) seed oil (HO) with without S9-mediated metabolic activation, using TA98 TA100 Salmonella Typhimurium strains. The MTT assay revealed no cytotoxicity HepG2 cells for HO quantities <TEX>$\leq400g$</TEX>/mL. In mutagenicity test, revertant colonies did not exceed spontaneous number. Colony numbers increase either strain after treatment, or activation. showed induce a...
Astaxanthin (AX), a natural carotenoid abundant in seafood, has hypolipidemic activity. Previously, we reported that AX is PPARα agonist and PPARγ antagonist reporter gene assay time‐resolved fluorescence energy transfer analyses, via direct binding to PPAR subtypes measured by surface plasmon resonance experiments, significantly reduced cellular lipid accumulation loaded hepatocytes. To confirm the effects of vivo , fed C57BL/6 mice standard high fat diet (HFD) for 8 weeks induce hepatic...