A5000928431- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Trauma Management and Diagnosis
- Organ Donation and Transplantation
- Palliative Care and End-of-Life Issues
- COVID-19 Clinical Research Studies
- Coronary Artery Anomalies
- Pericarditis and Cardiac Tamponade
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Grief, Bereavement, and Mental Health
- Cardiovascular Issues in Pregnancy
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
Radboud University Nijmegen
2016-2025
Catharina Ziekenhuis
2016-2025
Amsterdam University Medical Centers
2023
Isala
2023
Netherlands Heart Institute
2006-2022
Eindhoven University of Technology
2015-2017
University Medical Center Utrecht
2006-2012
Heidelberg University
2000-2012
University Hospital Heidelberg
2012
Deventer Ziekenhuis
2011
Background— Mutations in the plakophilin-2 gene ( PKP2 ) have been found patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC). Hence, genetic screening can potentially be a valuable tool diagnostic workup of ARVC. Methods and Results— To establish prevalence character mutations to study potential differences associated phenotype, we evaluated 96 index patients, including 56 who fulfilled published task force criteria. In addition, 114 family members from 34 these...
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival favorable neurologic outcome refractory out-of-hospital cardiac arrest is inconclusive.
This study aimed to give contemporary insight into the use of Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in acute myocardial infarction-related cardiogenic shock (AMICS) associated outcomes, adverse events, resource demands.This nationwide observational cohort describes all AMICS patients treated with (ABIOMED, Danvers, MA, USA) and/or VA-ECMO 2020-2021. were used 20% cases (n = 4088). older (34% vs. 13% >75 years, p < 0.001) less frequently presented after an...
Abstract Background The likelihood of return spontaneous circulation with conventional advanced life support is known to have an exponential decline and therefore neurological outcome after 20 min in patients a cardiac arrest poor. Initiation venoarterial ExtraCorporeal Membrane Oxygenation (ECMO) during resuscitation might improve outcomes if used time selected patient category. However, previous studies failed significantly reduce the from ECMO flow less than 60 min. We hypothesize that...
When out-of-hospital cardiac arrest (OHCA) becomes refractory, extracorporeal cardiopulmonary resuscitation (ECPR) is a potential option to restore circulation and improve the patient's outcome. However, ECPR requires specific materials highly skilled personnel, it unclear whether increased survival health-related quality of life (HRQOL) justify these costs.
Return of spontaneous circulation occurs in less than 10% patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR) for more 15 minutes. Studies suggest that extracorporeal life support during (ECPR) improves survival rate these patients. These studies, however, are hampered by their non-randomized, observational design and mostly single-center. A multicenter, randomized controlled trial is urgently warranted to evaluate the effectiveness ECPR. We hypothesize early...
While experimental data suggest that selective intracoronary hypothermia decreases infarct size, studies in patients with ST-elevation myocardial infarction (STEMI) are lacking.
Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) is associated with high morbidity and mortality. Our study aimed to gain insights into patient characteristics, outcomes treatment strategies in CS patients. Patients who underwent percutaneous coronary intervention (PCI) between 2017 2021 were identified a nationwide registry. Data on medical history, laboratory values, angiographic features retrospectively assessed. A total of 2328 patients mean age 66 years whom 73%...
In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes 1. However, reperfusion itself may also cause damage the myocardium increase IS. This has been termed injury 2. animal models acute infarction, it demonstrated that hypothermia decreases IS 3. contrast, human studies applying systemic cooling methods have not yet able confirm...
Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes. This real-world, multicentre registry included CS undergoing percutaneous coronary intervention between 2017 2021 14 hospitals. The impact on outcomes was analysed after 1:1 average propensity-score (aPS) matching....
Mortality in patients with acute myocardial infarction-related cardiogenic shock (AMICS) is high, but a widely accepted tool for individual risk assessment lacking. A reliable prediction model could assist clinical decision making, patient selection trials, and comparison of AMICS populations. Therefore, the aim this study was to develop externally validate 30-day mortality patients. This retrospective cohort included from 2017 2021(development cohort) 2010-2017 (validation cohort). Patients...
Abstract Background Mortality rates in patients with cardiogenic shock complicating acute myocardial infarction (AMICS) remain high despite advancements AMI care. Our study aimed to investigate the impact of prehospital symptom duration on prognosis AMICS and those receiving mechanical circulatory support (MCS). Methods results We conducted a retrospective cohort data registered Netherlands Heart Registration. A total 1,363 who underwent percutaneous coronary intervention between 2017 2021...
Aims: Hypothermia reduces reperfusion injury and infarct size in animal models of acute myocardial infarction if started before reperfusion.Human studies have not confirmed benefit, probably due to insufficient cooling adverse systemic effects.This study sought assess the safety feasibility a novel method for selective, sensor-monitored intracoronary hypothermia.