A5088260151- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Diverticular Disease and Complications
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Soft tissue tumor case studies
- Liver Diseases and Immunity
- Minimally Invasive Surgical Techniques
- Gallbladder and Bile Duct Disorders
- Hernia repair and management
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2016-2025
Cancer Center Amsterdam
2022-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2024
Dutch Cancer Society
2024
Amsterdam UMC Location University of Amsterdam
2012-2023
Bergman Clinics
2015-2022
Utrecht University
2022
University Medical Center Utrecht
2022
University Medical Center
2022
ESGE recommends that the evaluation of superficial gastrointestinal (GI) lesions should be made by an experienced endoscopist, using high definition white-light and chromoendoscopy (virtual or dye-based).ESGE does not recommend routine performance endoscopic ultrasonography (EUS), computed tomography (CT), magnetic resonance imaging (MRI), positron emission (PET)-CT prior to resection.ESGE submucosal dissection (ESD) as treatment choice for most esophageal squamous cell gastric lesions.For...
<h3>Objective</h3> Accurate endoscopic differentiation would enable to resect and discard small diminutive colonic lesions, thereby increasing cost-efficiency. Current classification systems based on narrow band imaging (NBI), however, do not include neoplastic sessile serrated adenomas/polyps (SSA/Ps). We aimed develop validate a new system for of adenomas, hyperplastic polyps SSA/Ps <10 mm. <h3>Design</h3> developed the Workgroup serrAted polypS Polyposis (WASP) classification,...
We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.From 2006 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, subjected them annual both endoscopic ultrasonography (EUS) MRI/cholangiopancreatography (MRI/MRCP) at each visit.366 (201 mutation-negative familial (FPC)...
The Paris classification is an international system for describing polyp morphology. Thus far, the validity and reproducibility of this have not been assessed. We aimed to determine interobserver agreement among seven Western expert endoscopists.A total 85 short endoscopic video clips depicting polyps were created assessed by endoscopists according classification. After a digital training module, same again. calculated with Fleiss kappa as proportion pairwise agreement.The experts was...
<b>Background and study aims:</b> Sessile serrated adenomas/polyps (SSA/Ps) are the precursors of 15 % – 30 colorectal cancers (CRC). We aimed to determine prevalence distribution SSA/Ps evaluate association between risk synchronous advanced neoplasia at a high quality colonoscopy center. <b>Methods:</b> Data from all colonoscopies performed within one dedicated center 2011 2015 were prospectively retrieved using an automated reporting system. All lesions assessed by experienced...
Abstract Background The risk of lymph node metastasis associated with deep submucosal invasion should be balanced against the mortality and morbidity total mesorectal excision (TME). Dissection through submucosa hinders radical resection, full-thickness resection may influence outcome completion TME. Endoscopic intermuscular dissection (EID) in between circular longitudinal part muscularis propria could potentially provide an R0 while leaving rectal wall intact. Methods In this prospective...
For patients with achalasia experiencing persistent or recurrent symptoms after laparoscopic Heller myotomy (LHM), pneumatic dilation (PD) is the most frequently used treatment. Per-oral endoscopic (POEM) increasingly being investigated as rescue therapy. This study aimed to determine efficacy of POEM vs PD for LHM.This randomized multicenter controlled trial included LHM an Eckardt score >3 and substantial stasis (≥2 cm) on timed barium esophagogram PD. The primary outcome was treatment...
Abstract Several extra-colonic manifestations, including duodenal polyposis and desmoid tumors, are well-described manifestations in familial adenomatous (FAP). More recently, an increase gastric cancer diagnoses has been observed FAP. This case series presents nine patients with FAP who were diagnosed at our expertise center, of whom eight between 2017 2023, while before the only diagnosis was 2001. Among cases cancer, seven located proximal stomach amidst carpeting fundic gland two distal...
Abstract Background Endoscopic full-thickness resection (eFTR) is a minimally invasive technique that allows definite diagnosis and treatment for complex colorectal lesions ≤ 30 mm unsuitable conventional endoscopic resection. This study reports clinical outcomes from the Dutch eFTR registry. Methods Consecutive patients undergoing in 20 hospitals were prospectively included. The primary outcome was technical success, defined as macroscopic complete en bloc Secondary were: tumor-free margins...
Background and aims Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals 1–2 years. However, yearly likely leads to overtreatment for many. We prospectively assessed a protocol aiming safely reduce the burden colonoscopies. Methods Between 2013 2018, we enrolled SPS patients from nine Dutch Spanish hospitals. Patients were surveilled using appointing either 1-year or 2-year interval after...
Complete endoscopic resection and accurate histological evaluation for T1 colorectal cancer (CRC) are critical in determining subsequent treatment. Endoscopic full-thickness (eFTR) is a new treatment option CRC < 2 cm. We aimed to report clinical outcomes short-term results.Consecutive eFTR procedures CRC, prospectively recorded our national registry between November 2015 April 2020, were retrospectively analyzed. Primary technical success R0 resection. Secondary risk assessment, curative...
Abstract Background Peroral endoscopic myotomy (POEM) is an effective and safe treatment for achalasia, but often leads to posttreatment gastroesophageal reflux disease. The aim of this study was examine the incidence severity esophagitis after POEM identify associated predictive factors. Methods Patients who underwent between August 2011 December 2022 were included. Multivariate logistic regression used assess factors POEM. Key Results In total, 252 patients included; which, 46% female age...
Peroral endoscopic myotomy (POEM) may result in a distended distal esophagus, referred to as blown-out (BOM), the relevance of which is uncertain. The aim this study was investigate prevalence, risk factors, and associated symptoms BOM after achalasia treatment.
BACKGROUND : Accurate polyp size measurement is important for risk stratification and decision-making regarding polypectomy surveillance. Recently, a virtual scale (VS) function has been developed that allows through projection of an adaptive VS onto colorectal polyps during real-time endoscopy. We aimed to evaluate the in terms variability systematic differences. METHODS conducted video-based study with 120 polyps, measured by eight dedicated gastroenterologists (experts) nine...
Lynch syndrome increases the risk of gastric cancer (GC) and duodenal (DC), particularly in individuals with
<b>Background and study aims:</b> Endoscopic optical diagnosis can potentially replace histopathological evaluation of small colorectal lesions. The aim this was to evaluate diagnostic performance WavSTAT, a novel system for automatic based on laser-induced autofluorescence spectroscopy. <b>Patients methods:</b> Consecutive patients who were scheduled colonoscopy included in the study. Each detected lesion with size ≤ 9 mm differentiated using high resolution endoscopy (HRE) by endoscopist,...