A5030808970- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Dysphagia Assessment and Management
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Platelet Disorders and Treatments
- Neuroscience of respiration and sleep
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Microscopic Colitis
- Potassium and Related Disorders
- Microbial Metabolites in Food Biotechnology
- Diverticular Disease and Complications
- Head and Neck Surgical Oncology
- Congenital Diaphragmatic Hernia Studies
Amsterdam University Medical Centers
2019-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2024
Cancer Center Amsterdam
2024
Bergman Clinics
2022-2024
Vrije Universiteit Amsterdam
2019-2024
University of Amsterdam
2009-2023
Amsterdam University of the Arts
2023
RELX Group (Netherlands)
2023
Amsterdam UMC Location University of Amsterdam
2005-2022
University Medical Center
2022
<h3>Introduction</h3> Gastro-oesophageal reflux occurs twice as much during transient lower oesophageal sphincter relaxations (TLOSRs) in patients with gastro-oesophageal disease (GORD) compared to healthy volunteers (HVs). Our aim was assess whether the localisation of postprandial acid pocket and its interaction a hiatal hernia (HH) play role occurrence acidic TLOSRs. <h3>Methods</h3> Ten HVs 22 GORD (12 HH<3 cm (s-HH), 10 HH≥3 (l-HH)) were studied. The squamocolumnar junction...
Summary and Recommendation This statement conveys the European Society of Gastrointestinal Endoscopy (ESGE) position on use computer-aided detection (CADe) with artificial intelligence (AI) during colonoscopy for colorectal cancer (CRC) screening or surveillance. The ESGE is informed by BMJ Rapid initiative approach MAGIC Evidence Ecosystem Foundation; these include systematic reviews currently available evidence, supplemented microsimulation modeling patient values preferences, benefits...
<h3>Objective</h3> To evaluate the efficacy and tolerability of add-on treatment with lesogaberan (AZD3355), a novel reflux inhibitor, in patients persistent gastro-oesophageal disease (GORD) symptoms despite proton pump inhibitor (PPI) therapy. <h3>Methods</h3> A double-blind, placebo-controlled, randomised, parallel-group, multicentre phase IIA study was carried out outpatient clinics. The group comprised 244 adult GORD (heartburn and/or regurgitation) at least mild intensity for 3 days 7...
Abstract Background Endoscopic full-thickness resection (eFTR) is a minimally invasive technique that allows definite diagnosis and treatment for complex colorectal lesions ≤ 30 mm unsuitable conventional endoscopic resection. This study reports clinical outcomes from the Dutch eFTR registry. Methods Consecutive patients undergoing in 20 hospitals were prospectively included. The primary outcome was technical success, defined as macroscopic complete en bloc Secondary were: tumor-free margins...
Complete endoscopic resection and accurate histological evaluation for T1 colorectal cancer (CRC) are critical in determining subsequent treatment. Endoscopic full-thickness (eFTR) is a new treatment option CRC < 2 cm. We aimed to report clinical outcomes short-term results.Consecutive eFTR procedures CRC, prospectively recorded our national registry between November 2015 April 2020, were retrospectively analyzed. Primary technical success R0 resection. Secondary risk assessment, curative...
Background Data are scarce on the efficacy and safety of motorized spiral enteroscopy (MSE). No data available utility this technique in patients with surgically altered gastrointestinal (GI) anatomy. We aimed to evaluate MSE suspected small-bowel disease, including those GI Methods A multicenter prospective observational, uncontrolled study evaluated consecutive pathology an indication for diagnostic and/or therapeutic intervention. Results total 170 (102 men; median age 64 years, range...
Refractory celiac disease type 2 (RCDII) is a rare condition with high mortality because of lack effective treatment strategies. RCDII caused by clonal expansion intraepithelial lymphocytes (IELs). Gain-of-function JAK1 mutations are frequently found in these cells.
Background and purpose: Transient lower oesophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastro‐oesophageal reflux a potential pharmacological treatment target. We evaluated effect of CB 1 /CB 2 receptor agonist Δ 9 ‐tetrahydrocannabinol (Δ ‐THC) on TLESRs in dogs. Based these findings, ‐THC was studied healthy volunteers. Experimental approach: In dogs, manometry used to evaluate presence absence antagonist SR141716A induced by gastric distension. Secondly, 10 20...
In the medical literature, nomenclature and descriptions (ND) of small bowel (SB) ulcerative inflammatory (U-I) lesions in capsule endoscopy (CE) are scarce inconsistent. Inter-observer variability interpreting these findings remains a major limitation assessment severity mucosal lesions, which can impact negatively on clinical care, training research SB-CE.
BACKGROUND : Accurate polyp size measurement is important for risk stratification and decision-making regarding polypectomy surveillance. Recently, a virtual scale (VS) function has been developed that allows through projection of an adaptive VS onto colorectal polyps during real-time endoscopy. We aimed to evaluate the in terms variability systematic differences. METHODS conducted video-based study with 120 polyps, measured by eight dedicated gastroenterologists (experts) nine...
Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) sinister pathology. We aimed to investigate DY of CE in a large cohort IDA patients, and evaluate factors predicting significant SB
OBJECTIVES: Reflux inhibitors, like the γ-aminobutyric acid type B (GABAB) receptor agonist, baclofen, block transient lower esophageal sphincter relaxations (TLESRs) and are proposed as an add-on therapy in patients with proton pump inhibitor (PPI)-resistant gastroesophageal reflux. However, other mechanisms of reflux become more important presence a hiatal hernia (HH), efficacy inhibitors to reduce non-acid exposure may be hampered. Therefore, we compared effect baclofen no HH (−HH) those...
See also: Commentaire de travail H. Beaumont et al., pp. 2Endoscopy 2009; 41(01): 94-94DOI: 10.1055/s-0032-1306720
Abstract Background Transient lower esophageal sphincter relaxations (TLESRs) are the predominant mechanisms underlying gastro‐esophageal reflux. TLESRs mediated by a vago‐vagal reflex, which can be blocked interaction with metabotropic Glutamate Receptor 5 (mGluR5), γ‐aminobutyric acid type B (GABA ), A and cannabinoid (CB) receptors. However, distribution of these receptors in neural pathway triggering has not been evaluated humans. Methods Using immunohistochemistry, we investigated...
Currently, the gold standard for diagnosis of coeliac disease (CD) is based on serology and gastroduodenoscopy with histology duodenal mucosal biopsies. The aim this study was to evaluate potential faecal volatile organic compounds (VOCs) analysis as a novel, non-invasive tool discriminate between CD in remission patients gluten-free diet (GFD), refractory (RCD) controls without CD. Patients an established GFD, RCD healthy (HC) were instructed collect sample. All subjects completed...
Summary Background Transient lower oesophageal sphincter relaxations (TLESRs) represent an interesting target for the treatment of gastro‐oesophageal reflux. Baclofen reduces TLESRs and reflux episodes, but is not optimal clinical application because its central side effects. Therefore, new agents are required. Aim To study effect AZD9343, a selective GABA B receptor agonist, in healthy volunteers. Methods A total 27 subjects participated placebo‐controlled, randomized, two‐centre phase I...
Abstract Background We aimed to document international practices in small-bowel capsule endoscopy (SBCE), measuring adherence European Society of Gastrointestinal Endoscopy (ESGE) technical and clinical recommendations. Methods Participants reached through the ESGE contact list completed a 52-item web-based survey. Results 217 responded from 47 countries (176 41, respectively, with or without national society affiliated ESGE). Of respondents, 45 % had undergone formal SBCE training. Among...
(1) Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features sometimes recognized; (2) Methods: The Delphi technique was employed to reach agreement among a panel of experts. nomenclature definitions lesions suggesting the presence were decided in core group 10 Four images each lesion chosen from large database on correspondence between picture definition evaluated using method broadened 36...