A5048949741- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Cardiovascular Health and Risk Factors
- Muscle activation and electromyography studies
- Hereditary Neurological Disorders
- Signaling Pathways in Disease
Gentofte Hospital
2015-2025
University of Copenhagen
2008-2023
Rigshospitalet
2009-2016
Copenhagen University Hospital
2016
Sahlgrenska University Hospital
2016
Odense University Hospital
2016
Sjællands Universitetshospital, Nykøbing F.
2016
University of Southern Denmark
2016
Medtronic (United States)
2016
Johns Hopkins University
2010-2015
Imaging-guided percutaneous coronary intervention (PCI) is associated with better clinical outcomes than angiography-guided PCI. Whether routine optical coherence tomography (OCT) guidance in PCI of lesions involving coronary-artery branch points (bifurcations) improves as compared angiographic uncertain. Download a PDF the Research Summary. We conducted multicenter, randomized, open-label trial at 38 centers Europe. Patients indication for and complex bifurcation lesion identified by means...
Background— The Nordic Aortic Valve Intervention (NOTION) trial was the first to randomize all-comers with severe native aortic valve stenosis either transcatheter replacement (TAVR) CoreValve self-expanding bioprosthesis or surgical (SAVR), including a lower-risk patient population than previous trials. This article reports 2-year clinical and echocardiographic outcomes from NOTION trial. Methods Results— Two-hundred eighty patients 3 centers in Denmark Sweden were randomized TAVR (n=145)...
Background— Tissue Doppler imaging (TDI) detects left ventricular dysfunction in patients with heart failure and normal ejection fraction, but the prognostic significance of by TDI general population is unknown. Methods Results— Within Copenhagen City Heart Study, a large community-based study, cardiac function was evaluated 1036 participants both conventional echocardiography TDI. Averages peak systolic (s′), early diastolic (e′), late (a′) velocities from 6 mitral annular sites were used....
Background— Transcatheter aortic valve implantation (TAVI) is an advancing mode of treatment for inoperable or high-risk patients with stenosis. Prosthetic endocarditis (PVE) after TAVI a serious complication, but only limited data exist on its incidence, outcome, and procedural risk factors. Methods Results— Observational single-center study 509 consecutive treated transcatheter implanted self-expandable prosthesis (Medtronic CoreValve). We identified 18 diagnosed TAVI-PVE during median...
To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) general population. Within a large, community-based population study, cardiac was evaluated 1036 participants by both conventional echocardiography colour TDI. Peak systolic (s′) early diastolic (e′) velocities, longitudinal displacement (LD), ratio of mitral inflow E-wave to e′ (E/e′) were measured. TDI revealed...
The detrimental effects of long-standing severe aortic stenosis (AS) often include left ventricular hypertrophy (LVH) and exhaustion coronary flow reserve (CFR), the reversibility which is unclear after valve replacement.
The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence new-onset atrial fibrillation (AF) cardiac events in patients with acute myocardial infarction (AMI) left ventricular (LV) systolic dysfunction.The performed as a substudy on CARISMA population. enrolled 312 an AMI LV ejection fraction <or=40%. Patients were implanted implantable loop recorder followed for 2 years. Sixty-two had full echocardiographic assessment function using...
AimsPre-implant assessment of longitudinal mechanical dyssynchrony using cross-correlation analysis (XCA) was tested for association with long-term survival and compared other tissue Doppler imaging (TDI)-derived indices.
Patients with severe aortic stenosis frequently have coexisting coronary artery disease. Invasive hyperemic and nonhyperemic pressure indices are used to assess disease severity but not been evaluated in the context of stenosis.We compared lesion reclassification rates fractional flow reserve (FFR) resting full-cycle ratio (RFR) measured before 6 months after transcatheter valve implantation using conventional clinical cutoffs ≤0.80 for FFR ≤0.89 RFR. This was a substudy ongoing NOTION-3...
Chronic total occlusions (CTO) are frequent among patients with coronary artery disease. Revascularization percutaneous intervention (PCI) is safe and feasible in experienced hands. However, randomized data needed to demonstrate symptomatic as well prognostic effect of CTO-PCI compared optimal medical therapy alone.This trial aims evaluate the CTO PCI a lesion target vessel diameter ≥ 2.5 mm, myocardial ischemia relevant territory. First, all subjected (OMT) for at least 3 months non-CTO...
To determine if colour tissue Doppler imaging (TDI) performed at rest in patients with suspected stable angina pectoris (SAP) is able to predict the presence of significant coronary artery disease (CAD). This study comprises 296 consecutive clinically SAP, no previous cardiac history, and a normal ejection fraction. All were examined by TDI, exercise electrocardiogram (ECG), angiography (CAG). Regional longitudinal systolic (s′), early diastolic (e′), late (a′) myocardial velocities measured...
Only 30% of patients receiving an implantable cardioverter defibrillator (ICD) for primary prevention receive appropriately therapy. We sought to investigate the value tissue Doppler imaging (TDI) predict ventricular tachycardia (VT), fibrillation (VF), and cardiovascular mortality (CVD) in with ICD. In total, 151 ICD meeting criteria no history arrhythmias were included. All participants examined by conventional 2D echocardiography TDI echocardiography. Longitudinal systolic ( s ′), early...
BACKGROUND: Limited information is available on the comparative efficacy and safety of different stent platforms in patients at high bleeding risk undergoing an abbreviated dual antiplatelet therapy duration after percutaneous coronary intervention (PCI). The aim this study was to compare effectiveness biodegradable-polymer sirolimus-eluting with durable-polymer zotarolimus-eluting receiving 1 month PCI. METHODS: Bioflow-DAPT Study international, randomized, open-label trial conducted 52...
To determine how the left ventricular wall motion assessed by echocardiographic Tissue Doppler Imaging (TDI) is affected increasing severity of coronary artery disease (CAD) among patients with stable angina pectoris and preserved ejection fraction. This study comprises 82 suspected pectoris, no previous cardiac history, a normal fraction, who were all examined colour TDI prior to angiography. Patients without significant stenoses ( n = 35) constituted control group 47) divided into three...