A5103127039- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Vitamin K Research Studies
- Aortic Disease and Treatment Approaches
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- Cardiovascular Effects of Exercise
- Bone Metabolism and Diseases
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Blood Coagulation and Thrombosis Mechanisms
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Medical Imaging Techniques and Applications
- Diversity and Career in Medicine
- Streptococcal Infections and Treatments
Maastricht University Medical Centre
2017-2024
Maastricht University
2012-2022
University of Edinburgh
2021
Radboud University Nijmegen
2017
Research Institute for Farm Animal Biology (FBN)
2017
Catharina Ziekenhuis
2017
Jessa Hospital
2017
University Hospital of Basel
2017
University of Basel
2017
RWTH Aachen University
2017
Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in stenosis. We assessed calcific and non-calcific disease using contrast-enhanced CT. Methods This was a post hoc analysis 164 patients (median age 71 (IQR 66–77) years, 78% male) with stenosis (41 mild, 89 moderate, 34 severe; 7% bicuspid) who underwent echocardiography as part imaging studies. Calcific (fibrosis) tissue volumes were quantified indexed to annulus area, Hounsfield unit...
Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide direct comparison the kinetics high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after exercise. In addition, effect remote ischemic preconditioning (RIPC), cardioprotective strategy that limits ischemia-reperfusion...
Idiopathic atrial fibrillation (AF) may be an expression of as yet undetected underlying heart disease. We found it useful for clinical practice to study the long-term development cardiovascular disease (CVD) in patients diagnosed with idiopathic AF. Forty-one consecutive AF (56 ± 10 years, 66% male) were compared 45 healthy control permanent sinus rhythm. Patients free hypertension, antihypertensive and antiarrhythmic drugs, diabetes, congestive failure, coronary artery or peripheral...
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements calcification in bicuspid aortic valve (BAV) and calcific stenosis (CAVS). BAV associated with early development CAVS. Pathophysiologic mechanisms are incompletely defined, only treatment available replacement upon progression to severe symptomatic stenosis. Matrix Gla protein (MGP) inactivity suggested be involved progression. Being K...
Background Vitamin K antagonists (VKAs) are associated with coronary artery calcification in low-risk populations, but their effect on of large arteries remains uncertain. The non-vitamin antagonist oral anticoagulants (NOACs) vascular is unknown. We investigated the influence use VKA and NOAC aorta aortic valve. Methods In patients atrial fibrillation without a history major adverse cardiac or cerebrovascular events who underwent computed tomographic angiography, presence ascending (AsAC),...
Background Patients with osteoporosis demonstrate increased vascular calcification but the effect of treatments on remains unclear. The present study aimed to examine whether coronary or aortic are influenced by denosumab and alendronic acid treatment. Methods Results In a double‐blind randomized controlled SALTIRE2 (Study Investigating Effect Drugs Used Treat Osteoporosis Progression Calcific Aortic Stenosis) trial, patients stenosis were 2:1:2:1 denosumab, placebo injection, acid, capsule....
A standard coronary artery calcium scan includes part of the aorta. This additional information is often not included in routine analyses. We aimed to determine feasibility assessing Agatston score descending aorta calcification (DAC) on scans and association this with events a low-risk study population.Between January 2008 March 2011, 390 consecutive patients who were referred for cardiac CT as work-up pulmonary vein isolation (n=115) or assessment presence disease (n=275) included. At...
Background: Atrial Fibrillation (AF) in patients without concomitant cardiovascular pathophysiological disease, is called idiopathic (iAF). Nonetheless, iAF have often times subclinical coronary (micro) vascular dysfunction and, particularly women, a higher prevalence of subsequent comorbidities. Previously, we identified plasma miRNA association with diabetes and microvascular injury Diabetic Nephropathy (DN) patients. Therefore, this study assessed whether levels these diabetic, associated...
Objective Cardiac biomarkers hold promise for follow-up and management of aortic valve stenosis (AVS). When interpreting serial biomarker measurements patients with AVS, it can be challenging to distinguish ‘real changes’ from ‘random fluctuation’. Hence, robust estimation the biological variation these is essential. In present study we assessed B-type natriuretic peptide (BNP), N-terminus pro-brain (NT-proBNP), high-sensitivity troponin-T troponin-I (hs-TnT hs-TnI), ST2 in subjects stable...
Bicuspid aortic valve (BAV) disease is associated with dilatation. Timing of follow-up and surgery challenging. Hence, there an unmet clinical need for additional risk stratification. It unclear whether morphology dilatation rates. Therefore, the objective this study was to examine association between echocardiographic determinants (including morphology) dimension progression rate Aortic dimensions were assessed on serial images 1999 2014 in a population 392 patients BAVs tertiary care...
Circulating biomarkers are useful in detection and monitoring of cardiovascular diseases. However, their role aortic valve disease is unclear. Mechanisms rapidly elucidated sex differences suggested to be involved. Therefore, we sought identify involved calcification (AVC) stratified by sex.Blood samples 34 patients with AVC (without further overt disease, including absence hemodynamic consequences valvular calcification) were compared 136 without AVC. was determined using computed...
Abstract Aims Vascular calcification is a hallmark of atherosclerotic burden and can predict the cardiovascular outcome. Vitamin K antagonists (VKA) are widely used anticoagulant drugs to treat patients at risk arterial venous thrombosis but also associated with increase vascular progression. We aim unravel paradox that VKA suppresses plasma coagulation promotes subsequent atherosclerosis-dependent coagulability vessel wall. Methods results Apoe −/− mice were placed on western-type diet...