A5076482587- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Operations and Scheduling Optimization
- Ion channel regulation and function
- Hospital Admissions and Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Nausea and vomiting management
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Surgical Simulation and Training
- Anesthesia and Neurotoxicity Research
- Total Knee Arthroplasty Outcomes
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Patient Safety and Medication Errors
- Music Therapy and Health
- Nicotinic Acetylcholine Receptors Study
- Airway Management and Intubation Techniques
- Surgical site infection prevention
- Receptor Mechanisms and Signaling
- Patient Satisfaction in Healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Kantonsspital Aarau
2015-2024
University of Zurich
2020
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2018
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2018
Resuscitation Council
2016
Kantonsspital Graubünden
2015
October 6 University
2010
GTx (United States)
2009
University Hospital of Basel
2004-2008
University of California, San Francisco
1998-2005
The advent of managed care, reduction costs, and advances in medical technology place increasing demands on anesthesiologists. Preoperative anxiety may go unnoticed an environment that stresses increased productivity. present study compares different methods for measuring preoperative anxiety, identifies certain patient characteristics predispose to high describes the quantity quality patients experience preoperatively. Seven hundred thirty-four participated study. We assessed aspects by...
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
Abstract Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes urgently needed. Methods results Aetiologies PMIs detected within an active surveillance response programme were centrally adjudicated by two independent physicians based on all information obtained during clinically indicated PMI work-up including imaging among consecutive high-risk patients...
In Brief The number of citations an article receives after its publication reflects recognition in the scientific community. present study, therefore, we identified and examined characteristics top 100 most frequently cited articles published anesthetic journals. These were using database Science Citation Index Expanded (SCI-EXPANDED, 1945 to present) Web SCIENCE®. most-cited received 707 least 197 citations, with a mean 283 per article. citation classics between 1954 1997 5 high-impact...
Tandem pore domain K + channels represent a new family of ion involved in the control background membrane conductances. We report structural and functional properties TWIK-related acid-sensitive channel (rTASK), member this cloned from rat cerebellum. The salient features primary amino acid sequence include four putative transmembrane domains and, unlike other tandem channels, PDZ (postsynaptic density protein, disk-large, zo-1) binding at C terminal. rTASK has distant overall homology to...
Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE incompletely understood.
In Brief We examined the dose-response relationship of intrathecal clonidine at small doses (≤150 μg) with respect to prolonging bupivacaine spinal anesthesia. aimed for establishing that would produce clinically relevant prolongation anesthesia and pain relief without significant side effects. Eighty orthopedic patients were randomly assigned intrathecally receive isobaric 0.5% bupivacaine, 18 mg, plus saline (Group 1), 37.5 μg 2), 75 3), 150 4). Duration sensory block (regression below...
Potassium channels are found in all mammalian cell types, and they perform many distinct functions both excitable non-excitable cells. These subserved by several different families of potassium distinguishable primary sequence features as well physiological characteristics. Of these families, the tandem pore domain a new class, primarily distinguished presence two pore-forming domains within single polypeptide chain. We have cloned member this family, TWIK-2, from human brain cDNA library....
Primary acute heart failure (AHF) is a common cause of hospitalization. AHF may also develop postoperatively (pAHF). The aim this study was to assess the incidence, phenotypes, determinants and outcomes pAHF following non-cardiac surgery.A total 9164 consecutive high-risk patients undergoing 11 262 inpatient surgeries were prospectively included. outcome pAHF, centrally adjudicated by independent cardiologists, determined. incidence 2.5% (95% confidence interval [CI] 2.2-2.8%); 51% occurred...
Background Recently, a new structural family of potassium channels characterized by two pore domains in tandem within their primary amino acid sequence was identified. These domain are not gated voltage and appear to be involved the control baseline membrane conductances. The goal this study identify mechanisms local anesthetic action on these channels. Methods Oocytes Xenopus laevis were injected with cRNA from five cloned (TASK, TREK-1, TOK1, ORK1, TWIK-1), effects several anesthetics...
Unlabelled BACKGROUND. The effect of vasoconstrictors on intracerebral hemodynamics in anesthetized patients is controversial. influence phenylephrine and norepinephrine the cerebral circulation was investigated isoflurane- or propofol-anesthetized using transcranial Doppler ultrasonography. Methods Forty were randomly assigned to have vasoconstrictor tests with during either isoflurane propofol anesthesia. Blood flow velocities simultaneously measured middle artery ipsilateral extracranial...
Summary Previous communication research in general medical practice has shown that effective enhances patient compliance, satisfaction and outcome. It is expected equally important anaesthesia, since patients often suffer from anxiety lack of knowledge about anaesthetic procedures. However, little known the nature during routine visits. The present study 57 authentic visits provides first results on structure content pre‐operative setting using Roter Interaction Analysis System (RIAS)....
The attitude, behaviour and communication skills of specialised doctors are increasingly recognised as important they have been identified training requirements. We designed a programme to teach in University Department Anaesthesia evaluated its effect on patient outcomes such satisfaction anxiety. 20 h was based videotaped reviews actual pre-operative visits role-playing. Effects anxiety were assessed using questionnaire. In addition, all participating anaesthetists the training. provide...
Background Previous studies have identified a volatile anesthetic-induced increase in baseline potassium permeability and concomitant neuronal inhibition. The emerging family of tandem pore domain channels seems to function as vivo. Therefore, we studied the effects clinically used anesthetics on recently described member this family. Methods A cDNA clone containing coding sequence KCNK5 was isolated from human brain library. Expression central nervous system determined by Northern blot...