A5042246970- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Osteoarthritis Treatment and Mechanisms
- Pregnancy-related medical research
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Surgical site infection prevention
- Mesenchymal stem cell research
- Total Knee Arthroplasty Outcomes
- Abdominal Trauma and Injuries
- Orthopaedic implants and arthroplasty
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Electrospun Nanofibers in Biomedical Applications
- Inflammatory mediators and NSAID effects
- E-commerce and Technology Innovations
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Frailty in Older Adults
- Periodontal Regeneration and Treatments
Novartis (Switzerland)
2021-2024
Swiss Tropical and Public Health Institute
2009-2024
University Hospital of Basel
2009-2024
University of Basel
2012-2024
Novartis Institutes for BioMedical Research
2021-2024
ObjectivesPain as central symptom of osteoarthritis (OA) needs to be addressed part successful treatment. The assessment pain feature disease or outcome in clinical practice and drug development remains a challenge due its multidimensionality the plethora confounders. This article aims at providing insights into our understanding OA pain-phenotypes suggests framework for systematic comprehensive assessments.MethodsThis narrative review is based on search current literature various...
Abstract Stromal Vascular Fraction (SVF) cells freshly isolated from adipose tissue include osteogenic- and vascular-progenitors, yet their relevance in bone fracture healing is currently unknown. Here, we investigated whether human SVF directly contribute to the repair of experimental fractures nude rats, explored feasibility/safety clinical use for augmentation upper arm elderly individuals. Human were loaded onto ceramic granules within fibrin gel implanted critical rat femoral after...
Engineered osteogenic constructs for bone repair typically involve complex and costly processes cell expansion.Adipose tissue includes mesenchymal precursors in large amounts, principle allowing an intraoperative production of grafts their immediate implantation.However, stromal vascular fraction (SVF) cells from adipose were reported to require a molecular trigger differentiate into functional osteoblasts.The present study tested whether physiological doses recombinant human BMP-2 (rhBMP-2)...
Osteoarthritis (OA) is a complex disease comprising diverse underlying patho-mechanisms. To enable the development of effective therapies, segmentation heterogenous patient population critical. This study aimed at identifying such clusters using two different machine learning algorithms.Using progression and incident cohorts Initiative (OAI) dataset, deep embedded clustering (DEC) multiple factor analysis with (MFAC) approaches, including 157 input-variables baseline, were employed to...
Abstract Purpose Anchor-based studies are today the most popular approach to determine a minimal important difference value for an outcome variable. However, variety of construction methods such values do exist. This constitutes challenge field. In order distinguish between more or less adequate methods, meaningful requirements can be helpful. For example, should not reflect intervention(s) patients exposed in study used construction, as they later allow compare interventions. requires that...
The relevance of femoral neck fractures (FNFs) increases with the ageing numerous societies, injury-related decline is observed in many patients. Treatment strategies have evolved towards primary joint replacement, but impact different approaches remains a matter debate. aim this trial was to evaluate benefit an anterior minimally-invasive (AMIS) compared lateral Hardinge (LAT) approach for hemiarthroplasty these oftentimes frail Four hundred thirty-nine patients were screened during...
In Brief Objective: To evaluate the impact of a single-shot preoperative antimicrobial prophylaxis (AMP) to reduce rate Surgical Site Infections (SSIs) in rural sub-Saharan hospital. Summary Background Data: We analyzed incidence SSIs Tanzanian hospital with very limited resources and found that AMP was administered after incision 88% without covering expected pathogens. Inadequacy mistiming proved be major risk factors for SSI this study.1 Subsequently, 21.6% patients developed an clean or...
Background Patient feedback after contact with a hospital is regarded as an important source of information for the improvement local healthcare services. Routine patient surveys are in widespread use to obtain such feedback. While general principles composition this kind have been described literature, it unknown which method and topics patients postcontact surveys. Material methods We invited 2931 consecutive who had in- or outpatient Department Orthopaedics Traumatology at University...
The reconstruction of complex midface defects is a challenging clinical scenario considering the high anatomical, functional, and aesthetic requirements. In this study, we proposed surgical treatment to achieve improved oral rehabilitation anatomical functional defect maxilla with vascularized, engineered composite graft. patient was 39-year-old female, postoperative after left hemimaxillectomy for ameloblastic carcinoma in 2010 tumor-free at 5-year oncological follow-up. hemimaxillary...
Abstract Background Pelvic fractures in older patients are associated with relevant morbidity and mortality. Both might be determined by fracture morphology and/or patient characteristics. The aim of this project is to investigate the prognostic value specific characteristics respect overall survival compare it an established classification system. Methods Retrospective analysis ≥ 60 years, treated conservatively for a CT-scan verified, low-energy pelvic ring between August 2006 December...
Abstract Background Eating disorders (EDs) are an increasingly recognized concern in professional sports. Previous studies suggests that both female gender and endurance sports put athletes at risk. Female elite cyclists hence of specific interest. The present study aimed evaluating the distribution individual risk ED this group. Further association between awareness for topic deviation from “normal” weight was depicted. Methods registered with Union Cycliste Internationale were contacted...
Subtalar dislocations are rare injuries and treatment recommendations missing. Gross contamination devascularisation aspects supporting talectomy as potential choice. Reconstruction in these cases can be challenging. The Masquelet technique presents one viable option. A carpenter sustained a high energy chrush injury with traumatic open lateral talar dislocation qualifying Gustillo Anderson type IIIc injury, mangeled extremity index of 7 gross contamination. severity soft tissue damage...