A5057556096- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- 3D Printing in Biomedical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Implant and Reconstruction
- Gallbladder and Bile Duct Disorders
- Surgical site infection prevention
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Reconstructive Surgery and Microvascular Techniques
- Colorectal Cancer Surgical Treatments
- HER2/EGFR in Cancer Research
- Pediatric Hepatobiliary Diseases and Treatments
- Breast Lesions and Carcinomas
- Appendicitis Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Immune cells in cancer
- Surgical Simulation and Training
University of Basel
2015-2025
University Hospital of Basel
2016-2025
Breast Center
2015-2022
Pius Hospital Oldenburg
2021
Charité - Universitätsmedizin Berlin
2021
St. Claraspital
2014-2020
Washington University in St. Louis
2013-2017
Hospital Base
2013-2015
Sivas State Hospital
2014
Epithelial cell adhesion molecule (EpCAM) is frequently expressed in breast cancer, and its expression has been associated with poor prognosis. Breast cancer can be subdivided into intrinsic subtypes, differing prognosis response to therapy. To investigate the association between EpCAM subtypes of we performed immunohistochemical studies on a tissue microarray encompassing total 1365 cancers detailed clinicopathological annotation outcomes data. We observed 660 out (48%) cases. varied...
Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to development immuneparesis, a complex interplay different immunosuppressive cells and soluble factors. Mechanisms underlying dynamics immuneparesis innate immunity remain inconclusive. We aimed dissect heterogeneity circulating monocyte states in stages, pursued function selected differentially expressed genes. systematically investigated monocytes health, compensated not-acutely...
Abstract Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here, we evaluate relevance cancer neoantigens in human breast cancers. Using patient-derived xenografts from three patients with advanced (xenografts were designated as WHIM30, WHIM35, WHIM37), sequenced exomes tumor patient-matched normal cells. We identified 2,091 (WHIM30), 354 (WHIM35), 235 (WHIM37) nonsynonymous somatic mutations. A computational analysis...
Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic molecular marker colorectal cancer (CRC) using immunohistochemical transcriptomic data. expression clinicopathologic information were obtained from The Cancer Genome Atlas dataset. association with cellular heterogeneity landscape was explored xCell method. evaluated cohort of 92 CRCs 19 non-tumoral found upregulated...
Abstract Background The incidence of hepatocellular carcinoma (HCC) is increasing in the western world over past decades. As liver resection (LR) represents one most efficient treatment options, advantages anatomic (ALR) versus non‐anatomic (NALR) show a lack consistent evidence. Therefore, aim this study was to investigate complications and survival rates after both types. Methods This multicentre cohort using retrospectively prospectively collected data. We included all patients undergoing...
// Benjamin Weixler 1 , Eleonora Cremonesi 2 Roberto Sorge 3 Manuele Giuseppe Muraro Tarik Delko Christian A. Nebiker Silvio Däster Valeria Governa Francesca Amicarella Savas D. Soysal 1,2 Christoph Kettelhack Urs W. von Holzen 1,4 Serenella Eppenberger-Castori 5 Giulio C. Spagnoli Daniel Oertli Giandomenica Iezzi Luigi Terracciano Tornillo Sconocchia 6,* and Raoul Droeser 1,2,* Department of Surgery, University Hospital Basel, Switzerland Institute Surgical Research Management (ICFS)...
Interaction between cancerous, non-transformed cells, and non-cellular components within the tumor microenvironment plays a key role in response to treatment. However, short-term culture or xenotransplantation of cancer specimens immunodeficient animals results dramatic modifications microenvironment, thus preventing reliable assessment compounds biologicals potential therapeutic relevance.We used perfusion-based bioreactor developed for tissue engineering purposes successfully maintain...
Background: Triple-negative breast cancer (TNBC) represents about 10-20% of all invasive cancers and is associated with a poor prognosis. The nectin cell adhesion protein 4 (Nectin-4) junction involved in the formation maintenance junctions. Nectin-4 has previously shown to be expressed 60% TNBC as well metastases, but absent normal tissue, which makes it potential specific target for therapy. Previous studies have an association expression worse prognosis small patient cohort. aim our study...
Since colorectal cancer (CRC) remains one of the most common malignancies, a tremendous amount studies keep taking place in this field. Over past 25 years, notable part scientific community has focused on association between immune system and cancer. A variety have shown that high densities infiltrating CD8+ T-cells are associated with improved disease-free overall survival CRC. Stromal cell-derived factor-1 (SDF-1) is protein regulates leukocyte trafficking variably expressed several...
Rationale: Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine biosynthesis. Here we sought to investigate the putative role of ADSL in colorectal carcinoma (CRC) carcinogenesis and response antimetabolites. Methods: expression levels were assessed by immunohistochemistry or retrieved from The Cancer Genome Atlas (TCGA) dataset. effects silencing overexpression evaluated on CRC cell proliferation, migration cell-cycle. In vivo tumor growth was chicken chorioallantoic...