A5006485099- Hedgehog Signaling Pathway Studies
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Apelin-related biomedical research
- Neonatal Respiratory Health Research
- Melanoma and MAPK Pathways
- Genetic and rare skin diseases.
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- HER2/EGFR in Cancer Research
- Neurological Disease Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Respiratory viral infections research
- Liver Diseases and Immunity
- Cutaneous Melanoma Detection and Management
- COVID-19 Clinical Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Sphingolipid Metabolism and Signaling
University of St. Gallen
2019-2025
Kantonsspital St. Gallen
2019-2024
Institute of Immunology
2022-2024
King's College Hospital
2014-2019
King's College London
2014-2019
Imperial College London
2017-2019
The King's College
2017
University of Medicine and Pharmacy of Craiova
2012
Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution acute hepatic are largely unknown. Here, we aimed to investigate the impact Mer tyrosine kinase (MerTK) during ALF also examine how microenvironmental mediator, secretory leucocyte protease inhibitor (SLPI), governs this response.Flow cytometry, immunohistochemistry, confocal imaging gene expression...
Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been identified to quell antimicrobial responses immune-mediated diseases. We sought delineate the function derivation of M-MDSC ACLF, explore potential targets augment responses.Patients ACLF (n=41) were compared healthy subjects (n=25) cirrhosis (n=22) or acute...
Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) investigate its prognostic predictive relevance cutaneous melanoma.
Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to development immuneparesis, a complex interplay different immunosuppressive cells and soluble factors. Mechanisms underlying dynamics immuneparesis innate immunity remain inconclusive. We aimed dissect heterogeneity circulating monocyte states in stages, pursued function selected differentially expressed genes. systematically investigated monocytes health, compensated not-acutely...
Predicting survival in decompensated cirrhosis (DC) is important decision making for liver transplantation and resource allocation. We investigated whether high-resolution metabolic profiling can determine a phenotype associated with 90-day survival.Two hundred forty-eight subjects underwent plasma metabotyping by (1)H nuclear magnetic resonance (NMR) spectroscopy reversed-phase ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-TOF-MS; DC:...
BackgroundCirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; a lesser extent; adaptive dysfunctions have been described as contributors CAID leading immune-paresis and impaired anti-microbial response cirrhosis. In this study, we examined the phenotype of CD8+ T cells disease aim evaluate changes that might contribute responses.MethodsSixty cirrhosis were prospectively recruited for study. from peripheral...
Cancer treatment with immune checkpoint blockade (ICB) often induces immune-related adverse events (irAEs). We hypothesized that proteins coexpressed in tumors and normal cells could be antigenic targets irAEs herein described DITAS (discovery of tumor-associated self-antigens) for their identification. computed transcriptional similarity between lung healthy tissue based on single-sample gene set enrichment analysis. This identified 10 tissue–specific genes highly expressed the tumors....
Rationale: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives: To assess whether IgA autoantibodies target lung-specific proteins and contribute severity. Methods: We collected 147 blood, 9 lung tissue, 36 BAL fluid samples from three tertiary hospitals in Switzerland one Germany. Severe COVID-19 was defined by the need...
Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation and substantially contribute to the high mortality. Mechanisms underlying immuneparesis remain underexplored. TAM receptors (TYRO3/AXL/MERTK) are important inhibitors innate immune responses. To understand pathophysiology cirrhosis, we detailed receptor expression relation monocyte function disease severity prior onset acute decompensation. TNF-α/IL-6 responses lipopolysaccharide were...
Neurogenesis persists throughout life in the adult mammalian brain. Because neurogenesis can only be assessed postmortem tissue, its functional significance remains undetermined, and identifying an vivo correlate of has become important goal. By studying pentylenetetrazole-induced brain stimulation a rat model kindling we accidentally discovered that 25±1 days periodic Sprague-Dawley rats led to highly efficient increase seizure susceptibility.By EEG, RT-PCR, western blotting...
Rationale: Immune checkpoint inhibitor (ICI)-related pneumonitis is a serious autoimmune event affecting as many 20% of patients with non-small-cell lung cancer (NSCLC), yet the factors underpinning its development in some and not others are poorly understood. Objectives: To investigate role autoantibodies autoreactive T cells against surfactant-related proteins pneumonitis. Methods: The study cohort consisted NSCLC who provided blood samples before during ICI treatment. Serum was used for...
Abstract Tumor-associated antigens (TAAs) are potential targets for T cell-based immunotherapy approaches in cutaneous melanoma. BNT111, an investigational lipoplex-formulated mRNA-based therapeutic cancer vaccine encoding melanoma TAAs NY-ESO-1, tyrosinase, MAGE-A3, and TPTE, is undergoing clinical testing adults. Expression of these pediatric unclear but a prerequisite feasibility this treatment approach children with Our main objective was to characterize expression those melanomas...
Background Anti-programmed cell death protein 1 (PD-1) antibodies are now routinely administered for metastatic melanoma and increasing numbers of other cancers, but still only a fraction patients respond. Better understanding the modes action predictive biomarkers clinical outcome is urgently required. Cancer rejection mostly T cell-mediated. We previously showed that presence NY-ESO-1-reactive and/or Melan-A-reactive cells in blood correlated with prolonged overall survival (OS)...
Abstract Purpose: Vismodegib is approved for the treatment of locally advanced basal cell carcinoma (laBCC), but some cases demonstrate intrinsic resistance (IR) to drug. We sought assess frequency IR vismodegib in laBCC and its underlying genomic mechanisms. Experimental Design: Response was evaluated a cohort 148 patients. Comprehensive transcriptomic profiling performed subset five intrinsically resistant BCC (IR-BCC). Results: identified that IR-BCC represents 6.1% studied cohort. Prior...