A5023064642- Immune Cell Function and Interaction
- Bladder and Urothelial Cancer Treatments
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Immune cells in cancer
- Malaria Research and Control
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Viral Infections and Vectors
- Antenna Design and Analysis
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- vaccines and immunoinformatics approaches
- Renal Transplantation Outcomes and Treatments
- Biosimilars and Bioanalytical Methods
- Immunotherapy and Immune Responses
University Hospital Bonn
2020-2025
QIMR Berghofer Medical Research Institute
2018-2024
University of Bonn
2020-2023
The University of Queensland
2018-2020
Control of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 to mitigate the pathology induced this inflammatory response. However, these IL-10-producing (induced type I regulatory [Tr1]) can also promote parasite persistence or impair immunity reinfection vaccination. Here, we identified molecular and phenotypic signatures that distinguished IL-10-Th1 from IL-10+Tr1 in Plasmodium falciparum-infected people who...
Tumor antigen-specific CD8+ T cells play a critical role in antitumor immunity. Clinical trials reinvigorating the immune system via checkpoint blockade (ICB) have shown remarkable clinical promise. Numerous studies identified an association between NKG7 expression and patient outcome across different malignancies. However, aside from these correlative observations, very little is known about its Herein, we utilized single-cell RNA sequencing (scRNA-seq) datasets, NKG7-deficient mice,...
Abstract Aberrations of the fibroblast growth factor receptor (FGFR) family members are frequently observed in metastatic urothelial cancer (mUC), and blocking FGF/FGFR signaling axis is used as a targeted therapeutic strategy for treating patients. Erdafitinib pan-FGFR inhibitor, which has recently been approved by FDA mUC with FGFR2/3 alterations. Although patients show initial response to erdafitinib, acquired resistance rapidly develops. Here, we found that adipocyte precursors promoted...
Amplification of the
Cytotoxicity is a cornerstone of immune defense, critical for combating tumors and infections. This process relies on the coordinated action granzymes pore-forming proteins, with Granzyme B (GZMB) Perforin (PRF1) being key markers most widely studied molecules pertaining to cytotoxicity. However, other human cytotoxic components remain underexplored, despite growing evidence their distinct, context-dependent roles. Natural Killer Cell Granule Protein 7 (NKG7) has recently emerged as crucial...
T-cell-engaging bispecific antibodies (T-BsAb) have produced impressive clinical responses in patients with relapsed/refractory B-cell malignancies, although treatment failure remains a major challenge. Growing evidence suggests that complex interplay between immune cells and tumor is implicated the mechanism of action therefore, understanding regulatory mechanisms might provide clue for how to improve efficacy T-BsAb therapy. Here, we investigated functional impact T (Treg) on anti-tumor...
Control of visceral leishmaniasis (VL) depends on pro-inflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites. However, cytokines produced by can damage tissues, and require tight regulation. cell IL-10 production is an important cell-autologous mechanism prevent such damage. IL-10-producing (type I regulatory; Tr1) also delay control parasites the generation immunity following drug treatment or vaccination. To identify molecules target alter...
We examined transcriptional changes in CD4+ T cells during blood-stage Plasmodium falciparum infection individuals without a history of previous parasite exposure. Transcription CXCL8 (encoding interleukin 8) was identified as an early biomarker submicroscopic P. infection, with predictive power for growth. Following antiparasitic drug treatment, T-cell regulatory phenotype developed. PD1 expression on CD49b+CD4+ (putative type I T) after treatment negatively correlated earlier Blockade but...
BACKGROUND. Impaired T cell immunity in transplant recipients is associated with infection-related morbidity and mortality. We recently reported the successful use of adoptive therapy (ACT) against drug-resistant/recurrent cytomegalovirus solid-organ recipients.
Cellular immunity against BK polyomavirus (BKV)-encoded antigens plays a crucial role in long-term protection virus-associated pathogenesis transplant recipients. However, in-depth understanding on dynamics of these cellular immune responses is required to develop better monitoring and immunotherapeutic strategies.Here, we have conducted proteome-wide analysis BKV-specific T-cell cohort 53 healthy individuals 26 kidney recipients delineate the functional transcriptional profile effector...
2048 Background: Standard of care (SOC) treatment achieves poor clinical outcomes in patients with glioblastoma (GBM), particularly the absence MGMT promoter hypermethylation. Preclinical models suggest that GBM recurrence is facilitated by CXCL12-mediated recruitment bone marrow-derived cells capable vasculogenesis after radiotherapy (RT). We have recently reported favorable safety and feasibility data phase I/II GLORIA trial, which combines RT CXCL12-neutralizing L-RNA aptamer olaptesed...
The development of highly effective malaria vaccines and improvement drug-treatment protocols to boost antiparasitic immunity are critical for elimination. However, the rapid establishment parasite-specific immune regulatory networks following exposure parasites hampers these efforts. Here, we identified stimulator interferon genes (STING) as a mediator type I production by CD4+ T cells during blood-stage Plasmodium falciparum infection. activation STING in cyclic guanosine...
Abstract Objectives There is an urgent need to be able identify individuals with asymptomatic Leishmania donovani infection, so their risk of progressing VL and transmitting parasites can managed. This study examined transcriptional markers expressed by CD4 + T cells that could distinguish from endemic controls visceral leishmaniasis (VL) patients. Methods were isolated L . RNA was extracted RNAseq employed differentially genes. The expression one gene its protein product during infection...
The upregulation of inhibitory molecules is a major driver immune escape in cancer. In contrast, less known about the regulation T cell activating receptors within tumor microenvironment. Here, we describe that derived CD155, transmembrane glycoprotein immunoglobulin superfamily, downregulates receptor CD226 (DNAM-1) mouse and human CD8+ cells, leading to profound loss effector function cancer evasion. Mechanistically, CD155 drives internalisation through phosphorylation tyrosine 319...
Supplementary Figures from NKG7 Is Required for Optimal Antitumor T-cell Immunity
Supplementary Figures from NKG7 Is Required for Optimal Antitumor T-cell Immunity
<p>Supplementary Figure3</p>