A5051231950- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Lymphatic System and Diseases
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Pelvic and Acetabular Injuries
- Nerve injury and regeneration
- Body Image and Dysmorphia Studies
- Body Contouring and Surgery
- Electrospun Nanofibers in Biomedical Applications
- Breast Lesions and Carcinomas
- Bone fractures and treatments
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Digital Imaging in Medicine
- History of Medical Practice
- Cardiac, Anesthesia and Surgical Outcomes
- Ubiquitin and proteasome pathways
- Systemic Sclerosis and Related Diseases
- Global Cancer Incidence and Screening
- Phagocytosis and Immune Regulation
University Hospital of Basel
2016-2025
University of Basel
2014-2025
Breast Center
2017-2024
Düsseldorf University Hospital
2023
Heinrich Heine University Düsseldorf
2023
University Health Network
2017
University of Toronto
2017
Zero to Three
2017
Vrije Universiteit Brussel
2017
University of California, San Francisco
2016
Abstract Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes urgently needed. Methods results Aetiologies PMIs detected within an active surveillance response programme were centrally adjudicated by two independent physicians based on all information obtained during clinically indicated PMI work-up including imaging among consecutive high-risk patients...
Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications post-mastectomy radiation therapy (PMRT) have broadened. The aim of Oncoplastic Breast Consortium initiative was to address relevant questions arising this clinically challenging scenario.A large global panel oncologic, oncoplastic reconstructive surgeons, patient advocates oncologists developed recommendations clinical practice in an iterative...
Abstract Introduction A range of behavioral testing paradigms have been developed for the research central and peripheral nerve injuries with help small animal models. Following any repair strategy, improved functional outcome may be most important evidence axon regeneration. novel automated gait analysis system, CatWalk ™ , can measure dynamic as well static patterns animals. Of interest in detecting recovery are particular parameters, coordination measures, intensity animals paw prints....
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is effective in patients melanoma, although long-term responses seem restricted who have complete remissions. Many develop secondary resistance to TIL-ACT but the involved mechanisms are unclear. In this study, we describe a case of possibly due intratumoral heterogeneity and selection resistant tumor clone by transferred T cells. To best our knowledge, first clonal pre-existing nondominant clone; report demonstrates...
Abstract In acute experimental autoimmune encephalomyelitis (EAE), demyelination is induced by myelin‐specific CD4 + T lymphocytes and antibodies. Recovery from the disease initiated cytokines which suppress cell expansion production of myelin‐toxic molecules macrophages. Th2/3 cell‐derived signals may also be involved in central nervous system (CNS) repair. Remyelination thought to recruitment differentiation oligodendrocyte precursor cells (OPC) demyelinated CNS lesions. Here, we report...
In aesthetic clinical practice, surgical outcome is best measured by patient satisfaction and quality of life. For many years, there has been a lack validated questionnaires. Recently, the FACE-Q was introduced, authors present largest series face-lift patients evaluated with longest follow-up to date.Two hundred consecutive were identified who underwent high-superficial musculoaponeurotic system face lifts, or without additional facial rejuvenation procedures, between January 2005 2015....
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Tissue engineering is a popular topic in peripheral nerve repair. Combining conduit with supporting adipose-derived cells could offer an opportunity to prevent time-consuming Schwann cell culture or the use of autograft its donor site morbidity and eventually improve clinical outcome. The aim this study was provide broad overview over promising transplantable under equal experimental conditions long-term period. A 10-mm gap sciatic female Sprague-Dawley rats (7 groups 7 animals, 8 weeks old)...
Traumatic nerve injuries are a major clinical challenge. Tissue engineering using combination of conduits and cell-based therapies represents promising approach to repair. The aim this study was examine the regeneration potential human adipose-derived stem cells (hASCs) after transplantation in nonautogenous setting compare them with autogenous rat ASCs (rASCs) for early peripheral regeneration. Furthermore, use MRI assess continuous process elaborated. sciatic injury model female...
The emphasis on aesthetic outcomes and quality of life (QoL) has motivated surgeons to develop skin-sparing or nipple-sparing mastectomy (SSM/ NSM) for breast cancer treatment prevention. During the same operation, a so-called immediate reconstruction is performed. can be reconstructed by positioning implant above (prepectoral) below (subpectoral) pectoralis major muscle using patients' own tissue (autologous reconstruction). optimal prepectoral subpectoral currently not clear. Subpectoral...
Endochondral ossification (ECO), the major process during embryogenesis and bone repair, involves formation of a cartilaginous template remodelled into functional organ. Adipose-derived stromal cells (ASC), non-skeletal multipotent progenitors from vascular fraction (SVF) human adipose tissue, were shown to recapitulate ECO generate organs in vivo when primed hypertrophic cartilage tissue (HCT) vitro. However, reproducibility was limited triggers remain unknown. We studied effect expansion...
Oncoplastic breast conserving surgery is increasingly used to treat patients with cancer. In the absence of randomized data, a large body observational evidence consistently indicates low rates recurrence and high survival, but points higher rate complications compared conventional surgery. Established goals oncoplastic are broaden indication for conservation towards larger tumors, improve esthetic outcomes. The benefit from patient's perspective, however, remains largely be confirmed. There...
Some studies have indicated age-specific differences in quality of life (QoL) among breast cancer (BC) patients. The aim this study was to compare patient-reported outcomes after conventional and oncoplastic surgery two distinct age groups.Patients who underwent for stage I-III BC, between 6/2011-3/2019, were identified from a prospectively maintained database. QoL evaluated using the Breast-Q questionnaire. Comparisons made women < 60 ≥ years.One hundred thirty-three patients included....
Abstract Purpose Vascularized lymph node transfer (VLNT) entails the autologous relocation of nodes to a lymphedematous region body, whereas lymphaticovenous anastomosis (LVA) creates direct bypass between lymphatic and venous system. Both techniques are meant lastingly bolster local drainage capacity. This study compared safety effectiveness VLNT LVA in patients with chronic breast cancer related lymphedema (BCRL). Methods A retrospective cohort was conducted using data from our encrypted...
Lipofilling for breast reconstruction has become increasingly common. Creation of a well-defined inframammary fold (IMF) is integral to achieving symmetrical aesthetic results. This traditionally been done under direct vision through an open incision. The authors present their experience in reconstructive surgery with novel percutaneous technique IMF creation and improvement projection without the need large incisions. From June 2011 January 2015, 180 patients underwent purse-string suture...