A5011842253- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Reconstructive Surgery and Microvascular Techniques
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Global Cancer Incidence and Screening
- Myasthenia Gravis and Thymoma
- DNA Repair Mechanisms
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Medical Coding and Health Information
- Reconstructive Facial Surgery Techniques
University Hospital of Basel
2022-2025
Breast Center
2021-2025
University of Basel
2021-2025
University Hospital of Zurich
2019-2022
University of Zurich
2022
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications post-mastectomy radiation therapy (PMRT) have broadened. The aim of Oncoplastic Breast Consortium initiative was to address relevant questions arising this clinically challenging scenario.A large global panel oncologic, oncoplastic reconstructive surgeons, patient advocates oncologists developed recommendations clinical practice in an iterative...
We developed tailored axillary surgery (TAS) to reduce the tumor volume in patients with clinically node-positive breast cancer point where radiotherapy can control it. The aim of this study was quantify extent load reduction achieved by TAS.
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden inform systemic therapy recommendations in patients with clinically (cN)–positive breast cancer (BC) is currently unknown. Objective To address the association ALND cN-positive BC upfront surgery setting and after neoadjuvant chemotherapy (NACT). Design, Setting, Participants This was a prospective, observational, cohort study conducted from August 2018 June 2022. preplanned within phase 3 randomized...
Abstract Background: Data on the oncologic safety of omission axillary lymph node dissection (ALND) in positive (N+) patients who downstage to ypN0 with neoadjuvant chemotherapy (NAC) is sparse. Additionally, there no consensus which staging procedure should be used this setting, sentinel biopsy (SLNB) alone or combination localization and retrieval clipped node, also known as targeted (TAD). Whether reduction false negative rate observed TAD translates into a significant recurrence unknown....
Long-term follow-up data from multicenter phase III non-inferiority trials confirmed the safety of omission axillary dissection in selected patients with clinically node-negative, sentinel node-positive breast cancer. Several ongoing investigate extended eligibility Z0011 protocol adjuvant setting. De-escalation surgery cancer is currently limited to neoadjuvant setting, where procedure used determine nodal pathological complete response. Targeted lowers false-negative rate procedure, which,...
The Choosing Wisely initiative recommended the omission of routine sentinel lymph node biopsy (SLNB) in patients ≥ 70 years age, with clinically node-negative, early stage, hormone receptor (HR) positive and human epidermal growth factor 2 (Her2) negative breast cancer August 2016. Here, we assess adherence to this recommendation a Swiss university hospital.We conducted retrospective single center cohort study from prospectively maintained database. Patients 18 age node-negative were treated...
Prepectoral implant-based reconstruction using synthetic meshes is feasible with good outcomes. We present our data TiLOOP® Bra Pocket, a novel ready-to-use mesh pocket which acts as an internal bra and prevents the implant from dislocating or twisting.A single-centre retrospective cohort study was performed to assess short-term complication rates cosmetic outcomes in patients prepectoral Pocket. The primary endpoint during first 6 months. secondary outcome after 12 months, judged by two...
Postoperative complications after breast cancer surgery may be associated with decreased quality of life. It remains unclear whether oncoplastic breast-conserving or mastectomy reconstruction lead to more postoperative than conventional (CBS). As delayed wound healing (DWH) is one the most frequent minor complications, we sought investigate significance DWH for patient-reported outcomes oncoplastic, reconstructive, and CBS.Our study a retrospective cohort consecutive patients stage I-II who...
The aim of this study was to evaluate clinical practice heterogeneity in use neoadjuvant systemic therapy (NST) for patients with clinically node-positive breast cancer Europe.The preplanned the international multicenter phase-III OPBC-03/TAXIS trial (ClinicalTrials.gov Identifier: NCT03513614) include first 500 randomized confirmed nodal disease at time surgery. TAXIS study's pragmatic design allowed both and adjuvant setting according preferences local investigators who were encouraged...
Oncoplastic breast conserving surgery (OBCS) aims to provide safe and satisfying for cancer patients. The American Society of Breast Surgeons (ASBrS) classification system is based on volumetric displacement cut-offs (level I <20% volume; level II 20-50%). It facilitate communication among treating physicians Here, we investigate whether the extent OBCS as classified by ASBrS independently predicts postoperative complications.This retrospective analysis a prospectively maintained database...
Poly (ADP‑ribose) polymerase (PARP)‑inhibitors (PARPi) such as olaparib and niraparib are currently used a treatment option for <em>BRCA</em>‑deficient tumors also show efficacy in platinum‑sensitive tumors. However, resistance to PARPi occurs numerous patients particular acquired presents major obstacle the of these In present study, it was investigated whether stepwise exposure ovarian cancer cells escalating concentrations produced subcells with and/or cross‑resistance platinum compounds,...
The aim of the study was to analyze impact neoadjuvant systemic treatment (NST) on postoperative complications and beginning adjuvant treatment.This includes data from a prospectively maintained database including patients with breast cancer (BC) stage I-IV or without NST undergoing surgery between January 2010 September 2021.Out 517 enrolled patients, 77 received NST, 440 had primary surgery. After underwent after meantime 34 days (26.5-40 days). No statistical significance could be found...
Abstract Introduction: Chemotherapy is recommended for patients with luminal breast cancer and more than three positive nodes. In addition, recent landmark trials raised the question if exact number of nodes required to indicate genomic testing. neoadjuvant setting, response-driven therapy increasingly used may be influenced by surgical staging axilla. The present study addressed role axillary lymph node dissection (ALND) as decision aid systemic in a contemporary cohort clinically...
Abstract Introduction: Even though randomized controlled trials could not show a significant survival benefit for the use of neoadjuvant systemic therapy (NST), it is increasingly recommended patients with clinically node-positive breast cancer due to its implications on prognosis, locoregional downstaging and response-driven adjuvant therapy. The aim this study was assess need international standardization treatment recommendations by evaluating clinical practice heterogeneity in NST...
Abstract Purpose Applying current treatment guidelines to elderly breast cancer (BC) patients is challenged by limited trial guidance, higher toxicities, and non-cancer related mortality. This study investigated adherence multidisciplinary team meeting (MDTM) recommendations in women with HER2 positive BC (HER2+BC) its impacts on patient survival. Methods retrospective multicentre cohort collected data from 305 primary diagnosis of HER2+BC. Women aged ≥65 years were classified into...
Obesity is increasing worldwide amongst the population at reproductive age and a known risk factor for health problems adverse pregnancy outcome. Nowadays bariatric surgery therapeutic option women who do not achieve weight loss through dietary modifications exercise. This study first matched cohort to compare fetal maternal outcomes after tertiary hospital in Switzerland.
Objective Approximately 45% of new breast cancer (BC) cases are diagnosed in women aged >65years. Nevertheless, elderly patients consistently underrepresented clinical trials. Furthermore, preexisting diseases, which might limit treatment options, occur frequently among these patients. Different studies have shown some approaches de-escalating strategies there is still a paucity research evaluating deviations from therapy guidelines HER2+ BC
Abstract Purpose: The aim of the study was to analyse impact neoadjuvant systemic treatment (NST) on postoperative complications and beginning adjuvant treatment. Methods: This includes data from a prospectively maintained database including patients with breast cancer (BC) stage I-IV or without NST undergoing surgery between January 2010 September 2021. Results: Out 517 enrolled patients, 77 received NST, 440 had primary surgery. After underwent after meantime 34 days (26.5 – 40 days). No...
Abstract Aim: To evaluate the perioperative outcome and cosmetic of prepectoral implant-based breast reconstruction using TiLOOP® Bra Pocket.Background: Besides acellular dermal matrix (ADM), synthetic meshes have revealed good surgical aesthetic outcomes. We present our data Pocket, a ready-to-use mesh pocket which is made out nonresorbable, titanized, lightweight polypropylene with monofilament structure designed to ensure optimal fixation implant following mastectomy. The idea behind fix...