A5071290495- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Palliative Care and End-of-Life Issues
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Advanced Breast Cancer Therapies
- Management of metastatic bone disease
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- Brain Metastases and Treatment
- Cutaneous lymphoproliferative disorders research
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Endometrial and Cervical Cancer Treatments
- Cutaneous Melanoma Detection and Management
- Medication Adherence and Compliance
- Family Support in Illness
- Urinary and Genital Oncology Studies
University of Basel
2021-2024
Bundesrechenzentrum (Austria)
2024
Breast Center
2013-2024
University Hospital of Basel
2010-2023
University of Zurich
2014-2023
Albert Einstein College of Medicine
2023
Immunologie-Zentrum Zürich
2017-2023
Witten/Herdecke University
2023
Swiss School of Tourism and Hospitality
2023
University Hospital of Zurich
2023
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
KCNMA1 encodes the α-subunit of large conductance, voltage and Ca2+-activated (BK) potassium channel has been reported as a target gene genomic amplification at 10q22 in prostate cancer. To investigate prevalence other human cancers, copy number was analyzed by fluorescence-in-situ-hybridization (FISH) 2,445 tumors across 118 different tumor types. Amplification restricted to small but distinct fraction breast, ovarian endometrial cancer with highest invasive ductal breast cancers serous...
Clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer is controversial. Here, we used a microarray including large series ductal and lobular cancers with long term follow up data, to analyze clinical impact TIL expressing specific phenotypes distribution TILs within different compartments histological subtypes.A tissue (TMA) 894 164 was stained antibodies recognizing CD4, FOXP3, IL-17 by standard immunohistochemical techniques. Lymphocyte counts were correlated...
Abstract Background: Data on the oncologic safety of omission axillary lymph node dissection (ALND) in positive (N+) patients who downstage to ypN0 with neoadjuvant chemotherapy (NAC) is sparse. Additionally, there no consensus which staging procedure should be used this setting, sentinel biopsy (SLNB) alone or combination localization and retrieval clipped node, also known as targeted (TAD). Whether reduction false negative rate observed TAD translates into a significant recurrence unknown....
The legalisation of assisted suicide is one the most debated topics in field medical ethics worldwide. In countries which not legal, public discussions about its approval also encompass considerations long-term consequences that such would bring, for example, how many people will use this option, from what conditions they be suffering, there differences between male and female developments trends could expected if were to a marked increase cases over time?In order answer these questions, we...
Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences factors that influence course of disease. Furthermore, those were conducted when currently accepted standards diagnostics and therapy had not been fully established. The objective current study was determine frequency sites metastases patients with particular attention clinical therapy.Autopsy reports, histologic slides, files from 197 who died carcinoma between 1975 2005...
Previous research evaluating the use of adjuvant endocrine therapy among postmenopausal breast cancer patients showed with 15-50% wide ranges non-adherence rates. We evaluated this issue by analysing an unselected study group comprising 325 women, diagnosed from 1997 to 2003 hormonal receptor-positive invasive cancer. The different clinical situations that led discontinuation were clearly defined and differentiated: was not simply act stopping medication, but rather manifestation intentional...
In Switzerland, the French-speaking region has an organized breast cancer (BC) screening program; in German-speaking region, only opportunistic until recently had been offered. We evaluated factors associated with attendance to these two regions. analyzed data of 50–69 year-old women (n = 2769) from Swiss Health Survey 2012. Factors interest included education level, place residence, nationality, marital status, smoking history, alcohol consumption, physical activity, diet, self-perceived...
Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are known to be related chemosensitivity. OX40 a TNF receptor member expressed on activated CD4+ CD8+ T cells. It that signaling promotes survival responds various immune cells of innate adaptive system. Therefore we investigated indicative value expression for recurrence in OC. A tissue...
Background. Approximately 10% of breast cancer (BC) patients are over the age 80. We present first comprehensive review on this particular group patients. Patients and methods. The treatments disease courses an unselected cohort patients, whose at diagnosis was ≥ 80 years (n = 151), were compared to those a women, who aged 56–66 372). Results. elderly had larger tumors (25 mm vs. 18 mm, p < 0.001) higher stages (I: 31.1% 44.1%, IV: 11.9% 5.4%; each 0.001). There no significant differences...
This study analyzes the association of body mass index (BMI) and prognostically relevant breast cancer (BC) characteristics in a country that has been rather spared global obesity epidemic.Based on 20-year data (1999-2009, n = 1,414) prospective relational BC database University Hospital Basel, Switzerland, associations between BMI, tumor size stage, histological subtype, grading, hormonal receptor status, HER2 status 'triple-negative' were evaluated. Multivariate analysis considered BMI...