A5021491935- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Cancer Risks and Factors
- Assisted Reproductive Technology and Twin Pregnancy
- BRCA gene mutations in cancer
- Reproductive System and Pregnancy
- Brain Metastases and Treatment
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
University Hospital of Bern
2019-2024
Ospedale Policlinico San Martino
2024
University Children’s Hospital Bern
2022-2024
University of Genoa
2024
University of Bern
2022
Klinik für Frauenheilkunde
2020
Olgahospital
2019
University Hospital of Basel
2013
Timing of ovulation triggering is essential in infertility treatments including based on natural menstrual cycles. However, data follicle size and oestradiol (E2) concentration are limited. Therefore, the model cycle IVF (NC-IVF) was applied to provide more detailed information these parameters better schedule optimal time for ovulation.A retrospective cross-sectional analysis 606 monofollicular NC-IVF cycles performed at a university-based centre from 2016 2019. Follicle E2 LH serum...
Cytotoxic treatments such as chemo- and radiotherapy immune therapies are required in cancer diseases. These have the potential to cure patients but may also an impact on gonadal function and, therefore, fertility. Consequently, fertility preservation freezing of gametes tissue might be required. However, detailed data about necessity perform treatment very limited, this study was designed fill gap.
Very limited evidence is available on the safety of assisted reproductive techniques (ART) in breast cancer (BC) patients harboring BRCA1/2 pathogenic variants (PVs). Hence, concerns remain among physicians counseling young BRCA carriers with BC ART use. This an international, multicenter, hospital-based, retrospective cohort study including women known PVs and diagnosed at ≤40 years stage I-III between January 2000 December 2020 (NCT03673306). analysis explored to achieve a pregnancy....
Does high-dose gonadotrophin stimulation have an effect on oocyte and early-stage embryo development?This was a retrospective study including 616 natural cycle IVF (NC-IVF) 167 conventional (cIVF) cycles. In total, 2110 oocytes were retrieved analysed in fresh NC-IVF, only human chorionic applied to trigger ovulation. cIVF, antagonist protocols with daily 150-300 IU of menopausal gonadotrophins performed. The development analysed. Primary outcomes the occurrence mature (metaphase II)...
It is known that Clomiphene citrate (CC) reduces endometrial thickness, but it unknown if additional gonadotrophin stimulation increases thickness and this has an effect on implantation rate in vitro fertilization (IVF). The retrospective study included 263 minimal IVF-cycles stimulated with 25 mg CC per day (CC-IVF), 161 plus 75IU hMG (human Menopausal Gonadotrophin) (CC/hMG-IVF). Endometrial oestradiol (E2) measurements were analysed between -4 0 (0 = of oocyte retrieval) the association...
Approximately 10% to 15% of breast cancer cases in young women are diagnosed patients harbouring germline (g) pathogenic or likely variants (PVs) the BReast CAncer 1 (
Abstract Study question Does assisted reproductive technology (ART) to achieve pregnancy after breast cancer (BC) adversely affect maternal or fetal outcomes in germline BRCA1/2 pathogenic variants (PVs) carriers? Summary answer This global study showed that ART is safe BC survivors harboring PVs, with no apparent worsening of prognosis outcomes. What known already Very little information currently available on the safety fertility treatments PVs. The previous published work this topic...
Abstract Study question What is the pain intensity of oocyte retrieval (oocyte pick-up, OPU) without anesthesia and analgesia in women with low or medium number follicles? Summary answer Pain only mild slightly different cycles up to 5 aspirated oocytes repeated In-Vitro-Fertilisation (IVF) cycles. known already OPU usually performed anesthesia. However, requires more treatment time expensive. Previous studies have assessed OPUs conventionally stimulated IVF using 15 19 gauge (G) aspiration...
What is the pain intensity of oocyte retrieval (OCR) without anaesthesia and analgesia in women with a low or medium number follicles? Multicentre observational study analysing IVF cycles seven centres Germany Switzerland between January 2022 March 2023. In total, 2290 natural cycle minimal stimulation from 1039 patients were recorded. Pain score was assessed using VAS graded 0 to 10. A descriptive analysis conducted, followed by statistical evaluation linear mixed model analyse effect on...
<sec> <title>BACKGROUND</title> Cytotoxic treatments such as chemo- and radiotherapy immune therapies are required in cancer diseases. These have the potential to cure patients but may also an impact on gonadal function and, therefore, fertility. Consequently, fertility preservation freezing of gametes tissue might be required. However, detailed data about necessity perform treatment very limited, this study was designed fill gap. </sec> <title>OBJECTIVE</title> Primary objective is analyze...
Zusammenfassung Hintergrund Zunehmend werden neben den klassischen IVF(In-vitro Fertilisation)-Therapien nichtklassische IVF-Therapien ohne Stimulation (Natural-Cycle-IVF) oder mit einer nur sehr geringen Gonadotropinstimulation (Minimal-Stimulation-IVF) durchgeführt. Diese nichtklassischen unter Reproduktionsmedizinern kontrovers diskutiert. Fragestellung Wie unterschieden sich diese Therapieformen und warum sie diskutiert? Material Methoden Basierend auf der aktuellen Literatur eigenen...
Endometrial thickness <8 mm is related with lower pregnancy rates. This raises the question if endometrial can be increased by gonadotropin stimulation to increase estradiol (E2) concentration and such an artificial thickening of endometrium has effect on implantation. A model address this comparison outcome parameters in conventional stimulated IVF (cIVF) compared unstimulated natural cycle (NC-IVF).Retrospective study including 235 cIVF 616 NC-IVF cycles without embryo selection fresh...
Abstract Study question Is endometrial growth and thickness different in controlled ovarian stimulation (COS)-IVF compared to unstimulated cycles does this have an effect on pregnancy rates? Summary answer Endometrial dynamic is endometrium thicker COS-IVF but not a positive live birth rates. What known already are function of duration concentration estradiol (E2) stimulation. &lt;8mm related with lower rates IVF treatments. It commonly assumed that increase by increasing estrogen could...
Abstract Study question What is the best follicle size, estradiol (E2) serum concentration and endometrial thickness to trigger ovulation in natural cycles? Summary answer Optimal follicles size 18–22mm but estrogen also need be considered maximize oocyte maturity minimize premature LH surge. known already Timing of triggering essential infertility treatments based on menstrual cycles such as optimized vaginal intercourse, intrauterine inseminations thawing without hormone replacement...