A5004165533- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Frailty in Older Adults
- Medical Image Segmentation Techniques
- Ovarian cancer diagnosis and treatment
- Bone health and treatments
- Augmented Reality Applications
- Estrogen and related hormone effects
- Surgical Simulation and Training
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Breast Lesions and Carcinomas
- Cancer survivorship and care
- Oral and Maxillofacial Pathology
- PARP inhibition in cancer therapy
- Robotics and Sensor-Based Localization
- Endometrial and Cervical Cancer Treatments
Kantonsspital Baselland
2022-2025
Theological Seminary Bienenberg
2025
University Hospital of Basel
2014-2024
Psychiatry Baselland
2022-2024
University of Basel
2017-2024
Mannheim University of Applied Sciences
2007-2023
Breast Center
2012-2023
Martin Luther University Halle-Wittenberg
2007-2019
TU Dresden
2019
Witten/Herdecke University
2019
The ability of circulating tumor cells (CTCs) to form clusters has been linked increased metastatic potential. Yet biological features and vulnerabilities CTC remain largely unknown. Here, we profile the DNA methylation landscape single CTCs from breast cancer patients mouse models on a genome-wide scale. We find that binding sites for stemness- proliferation-associated transcription factors are specifically hypomethylated in clusters, including OCT4, NANOG, SOX2, SIN3A, paralleling...
Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, and latter display an extraordinary ability to initiate metastasis. Yet, biological phenomena that trigger shedding CTC clusters a primary cancerous lesion poorly understood. Here, when dynamically labeling breast cancer along progression, we observe majority undergoing hypoxia, while CTCs largely normoxic. Strikingly, find vascular endothelial growth factor (VEGF) targeting leads shrinkage,...
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
Abstract This study investigates the effects of kyphoplasty on pain and mobility in patients with osteoporosis painful vertebral fractures compared conventional medical management. Introduction: Pharmacological treatment primary does not prevent impaired activity fractures. Therefore, we evaluated clinical outcome after associated chronic for >12 months. Materials Methods: Sixty presenting months were included this prospective, nonrandomized controlled study. Twenty-four hours before...
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement metastasis. In this study, we link radiation-induced changes of to their ability promote migration recipient HNSCC cells. We demonstrate isolated from irradiated donor cells boost the motility BHY FaDu. Molecular data identified enhanced AKT-signalling,...
The aim of the Medical Imaging Interaction Toolkit (MITK) is to facilitate creation clinically usable image-based software. Clinically software for image-guided procedures and image analysis require a high degree interaction verify and, if necessary, correct results from (semi-)automatic algorithms. MITK class library basing on extending Insight (ITK) Visualization (VTK). ITK provides leading-edge registration segmentation algorithms forms algorithmic basis. VTK has powerful visualization...
In this paper we introduce EfficientPose, a new approach for 6D object pose estimation. Our method is highly accurate, efficient and scalable over wide range of computational resources. Moreover, it can detect the 2D bounding box multiple objects instances as well estimate their full poses in single shot. This eliminates significant increase runtime when dealing with other approaches suffer from. These aim to first targets, e.g. keypoints, solve Perspective-n-Point problem each afterwards....
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared paclitaxel/bevacizumab. This multicenter, randomized phase III trial either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide B) as first-line treatment patients HER2-negative advanced cancer. The primary endpoint was the incidence of selected grade 3–5 adverse...
The effectiveness of intensive care unit (ICU) for cancer patients remains controversial. Advances in antitumour and supportive led to major improvements outcomes oncological the ICU. Improved therapies management organ dysfunctions have contributed improved survival rates. As a consequence, number requiring ICU admission is rising. Frequently, poor performance status are vulnerable. It heterogeneous population, where nature curability neoplasm severity critical illness cause plethora issues...
Endocrine therapy is used as maintenance in estrogen receptor (ER) positive breast cancers and has been proposed low-grade serous ovarian (LGSOC). Here we examine a rationale for its use high-grade (HGSOC).We accessed the TCGA PANCAN dataset to evaluate expression of ESR1. ESR1 data on all (n=8901) HGSOC (n=527) were followed by investigation ER via immunohistochemistry (IHC) (n=4071). The same was performed an independent cohort matched primary recurrent (n=80). Finally, newly diagnosed ER+...
Background. Approximately 10% of breast cancer (BC) patients are over the age 80. We present first comprehensive review on this particular group patients. Patients and methods. The treatments disease courses an unselected cohort patients, whose at diagnosis was ≥ 80 years (n = 151), were compared to those a women, who aged 56–66 372). Results. elderly had larger tumors (25 mm vs. 18 mm, p < 0.001) higher stages (I: 31.1% 44.1%, IV: 11.9% 5.4%; each 0.001). There no significant differences...
The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable only minority progressive cancer, and factors that influence the abundance remain elusive. We conducted CTC isolation enumeration selected group 73 consecutive characterized by invasive high load treatment discontinuation at time isolation. were quantified Parsortix microfluidic device. Clinicopathological variables, blood counts detailed history prior...
Abstract Blood-borne metastasis of breast cancer involves a series tightly regulated sequential steps, including the growth primary tumor lesion, intravasation circulating cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each these steps are poorly understood physiologically relevant contexts, owing to rarity experimental models that faithfully recapitulate biology, kinetics, tropism human cancer. Here, we conducted an vivo loss-of-function CRISPR...