A5047474485- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Palliative Care and End-of-Life Issues
- Virus-based gene therapy research
- RNA Research and Splicing
- Radiopharmaceutical Chemistry and Applications
- BRCA gene mutations in cancer
- Uterine Myomas and Treatments
- interferon and immune responses
- Protist diversity and phylogeny
- CAR-T cell therapy research
- Microtubule and mitosis dynamics
- Breast Lesions and Carcinomas
Tongji University
2013-2025
Tongji Hospital
2023-2025
Yangpu Hospital of Tongji University
2013-2024
New Era College
2023
Gansu Agricultural University
2022
Engineering (Italy)
2021
Shanghai University of Medicine and Health Sciences
2017
University Hospital of Basel
2017
University of Basel
2011-2013
Zhongda Hospital Southeast University
2009
MicroRNAs (miRNAs) are a class of small noncoding RNAs whose expression changes associated with cancer development and invasion. We hypothesized that miR-10b miR-373, which increased in lymphatic metastatic tissues, could be directly assayed the plasma used to detect lymph node status breast patients. Between November 2009 January 2012, 35 ductal carcinoma patients metastasis (N patients), 25 without (N(0) ten healthy female donors were enrolled study. Circulating miR-373 determined...
Abstract Background We observed an increased presence of succinate dehydrogenase complex subunit A (SDHA), a mitochondrial enzyme, in breast cancer (BC), which contributes to its proliferation. While SDHA deficiency has been extensively researched rare disorders, the upregulation and impact on BC remain understudied. The aim this study is investigate role BC. Methods mRNA expression was analyzed from TCGA, clinical tissues various cell lines via qPCR. Immunohistochemistry also applied detect...
Cellular adaptive mechanisms are crucial for tumorigenesis and a common feature in solid tumor progression. Hypoxia-inducible factor-1α (HIF-1α) facilitates the biological response to hypoxia, advancing angiogenesis metastatic potential of tumor. The peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α) enhances mitochondrial biogenesis, favored by migratory/invasive cancer cells. We conducted prospective, long-term follow up study determine whether HIF-1α PGC-1α can be...
Surgical resection is the main treatment option for most solid tumors, yet cancer recurrence after surgical remains a significant challenge in therapy. Recent advances immunotherapy are enabling radical cures many tumor patients, but these technologies remain challenging to apply because of side effects related uncontrollable immune system activation. Here, we develop far-red light-controlled immunomodulatory engineered cells (FLICs) that load into hydrogel scaffold, precise optogenetic...
Far-red light–inducible CRISPR-Cas12a/dCas12a systems were developed for controllable gene editing and activation.
Chimeric antigen receptor (CAR)-engineered T cell therapies have been recognized as powerful strategies in cancer immunotherapy; however, the clinical application of CAR-T is currently constrained by severe adverse effects patients, caused excessive cytotoxic activity and poor control. Herein, we harnessed a dietary molecule resveratrol (RES)-responsive transactivator transrepressor to develop repressible transgene expression (RESrep) device an inducible (RESind) device, respectively. After...
The effectiveness of intensive care unit (ICU) for cancer patients remains controversial. Advances in antitumour and supportive led to major improvements outcomes oncological the ICU. Improved therapies management organ dysfunctions have contributed improved survival rates. As a consequence, number requiring ICU admission is rising. Frequently, poor performance status are vulnerable. It heterogeneous population, where nature curability neoplasm severity critical illness cause plethora issues...
This study investigated the anticancer effect and mechanism of salinomycin, a selective inhibitor cancer stem cell, on human ovarian cell line OV2008 in vitro vivo. The growth inhibitory salinomycin was determined by measuring viability using resazurin reduction assay. Apoptotic nuclear morphology visualized 4,6-diamino-2-phenylindole staining technique. percentages apoptotic cells cycle parameters were detected flow cytometry. activity p38 mitogen-activated protein kinase (p38 MAPK)...
Breast cancer (BC) is one of the most common malignant cancers in females worldwide and greatly threatens women's health. The C-type lectin domain family 10 member A (CLEC10A) a receptor that has been previously reported to promote antitumor activity immune cells. In present study, potential prognostic value CLEC10A expression BC was assessed using data from Cancer Genome Atlas online database. Differences mRNA levels between normal tissues were then analyzed Tumor Immune Estimation Resource...
Background and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare for which surgery or combined with radiotherapy (RT) primary treatment method. However, recently, therapeutic effect RT on MPTB has been controversial. We aimed to explore role RT, chemotherapy (CT), surgical modalities in patients MPTB. Methods: The Surveillance, Epidemiology, End Results (SEER) database was used select who met criteria between 2010 2018. Kaplan–Meier curves Cox proportional risk regression...
Mammalian sterile 20-like kinase 1 (Mst1) has been proved in the process of apoptosis and tumor suppression. The aim study was to investigate expression Mst1 breast cancer evaluate its prognostic significance. examined 110 patients by immunohistochemistry, which 80 (72.7 %) were defined as positive for expression. Patients with negative had poor overall survival, comparing those using Kaplan-Meier survival analysis (P = 0.009). Multivariate Cox proportional hazards model showed that a...
Hepatic inflammatory pseudotumors (HIPT) are rare benign neoplasms with unknown etiology and a great potential for mimicry, challenging diagnostics, treatment features. The aim of the study was to retrospectively analyze imaging, pathological, clinical features HIPT in our large cohort patients order increase understanding suggest scoring system approaches. Retrospective analyzed 114 cases recorded from July 2006 2012, when surgery performed. Data were compared chi-square test. In...
Bone targeted therapies are of increasing importance, not only for bone health in the clinical course breast cancer, but recently also adjuvant setting as preventative, anticancer and prognosis-improving agents. It is well established that women with advanced cancer receive bisphosphonates or denosumab to prevent therapy-related osteoporosis. As many 70% these patients suffer from metastases agents order skeletal related events (SREs), which debilitating diminish quality life. A number...
Approximately one in four myocardial infarctions occur older patients. The majority of therapeutic advances are either not appropriate or tested elderly main reasons for deviating from the guidelines justified concerns regarding effectiveness recommended forms therapy, fear adverse drug reactions and ethical concerns. Targeting interleukin 6 (IL‑6) ventricular remodeling after cardiovascular damage is a feasible alternative to standard polypharmaceutics, but underlying molecular mechanisms...