A5100650885- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Diabetes Treatment and Management
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Pediatric Hepatobiliary Diseases and Treatments
- Diabetes Management and Research
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Metabolomics and Mass Spectrometry Studies
- T-cell and B-cell Immunology
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Hematopoietic Stem Cell Transplantation
- Metabolism, Diabetes, and Cancer
- Drug-Induced Hepatotoxicity and Protection
- Monoclonal and Polyclonal Antibodies Research
- Alcohol Consumption and Health Effects
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- HIV/AIDS drug development and treatment
- Neurological Disease Mechanisms and Treatments
- Nutrition and Health in Aging
Peking University People's Hospital
2016-2025
Peking University
2016-2025
Tongji University
2010-2025
Shanghai Jiao Tong University
2025
Shanghai East Hospital
2012-2025
First Affiliated Hospital of Henan University
2025
Ruijin Hospital
2025
University of California, San Diego
2024
China Medical University
2000-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis. Evidence has shown that antiviral therapy can reverse liver or even early cirrhosis caused by hepatitis B virus. However, current evaluation systems mainly focus on severity of, but not in, fibrosis. Here, we propose a new classification to evaluate in quality fibrosis, namely: predominantly progressive (thick/broad/loose/pale septa with inflammation); predominately regressive...
Neurotrophins are a family of soluble polypeptide growth factors widely recognized for their roles in the mammalian nervous system.One such neurotrophin, brain-derived neurotrophic factor (BDNF) was originally described system but has now been shown to be expressed variety nonneuronal tissues including endocrine tissues.We examined human ovarian follicle its possible secretion BDNF and further studied mouse oocytes determine BDNF's influence upon oocyte maturation.In series experiments...
Background Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-protective effects in patients with DKD, independent their glucose-lowering effects. However, underlying mechanism remains unclear. This study hypothesized SGLT2i could alleviate diabetic injury by inhibiting ferroptosis and explored its potential mechanisms.
Background Utilizing the National Health and Nutrition Examination Survey (NHANES) dataset to investigate relationship between dietary quality, as assessed by Healthy Eating Index-2015 (HEI-2015), prevalence of metabolic associated fatty liver disease (MAFLD) among adults in United States, our analysis revealed that an increased quality was significantly correlated with a reduced risk MAFLD American population. Method The NHANES dataset, encompassing years 2017–2018 comprising 3,557...
Abstract An alternative adaptive-immune system is present in the most basal vertebrates—lampreys and hagfish—the only surviving jawless vertebrates. These eel-like fish use leucine-rich repeat–based receptors for Ag recognition instead of Ig-based used jawed We report that Japanese lamprey (Lampetra japonica), variable lymphocyte receptor (VLR)B interacts with C1q C3 proteins to mediate complement-dependent cytotoxicity bacteria tumor cells. The immune-based lysis involves deposition VLRB...
The purpose of this study was to characterize the changes in metabolic intermediates and investigate profile a mouse model fulminant hepatic failure (FHF), induced by d-galactosamine/lipopolysaccharide (GalN/LPS). Plasma metabolite levels were detected using gas chromatography/time-of-flight mass spectrometry, acquired data transferred into Simca-P processed principal components analysis (PCA). In total, 45 metabolites identified from 267 distinct compounds found study. Whereas significant...
Early prediction of spontaneous hepatitis B virus e antigen (HBeAg) seroconversion is pivotal in the prevention unnecessary drug prescription, corresponding financial burden, and adverse reactions. One hundred thirteen chronic patients with HBeAg-positive immune active phase were followed up for about 1.5 years. Patients classified into two groups: HBeAg group (group A, n = 18) non-spontaneous group. Among group, 35 selected as controls B, 35). At week 12, there was a significant difference...
It is unclear whether liver stiffness measurement (LSM) dynamic changes after anti-HBV treatment could predict the risk of liver-related events (LREs), particularly in patients with HBV-related compensated cirrhosis.Treatment-naïve cirrhosis were enrolled. All under entecavir-based antiviral therapy, and followed up every 26 weeks for 2 years. The association between LSM LREs was analysed by Cox proportional hazard model Harrell C-index analysis.A total 438 included study. At follow-up 104...
Abstract Hepatitis C virus (HCV) infection is the main cause of hepatocellular carcinoma (HCC) in United States (US) and an increasingly common HCC China. We aimed to evaluate incidence risk factors HCV patients US 795 RNA + without from University Michigan Health System (UMHS) 854 Peking Sciences Center (PUHSC) China were prospectively followed for a median 3.2 4.0 years, respectively. 45.4% UMHS 16.2% PUHSC had cirrhosis. 57.6% 52.0% achieved SVR. 45 13 developed HCC. Cumulative at 5 years...
Abstract Background Nucleos(t)ide analogues (NAs) cessation is not widely practiced and remains a controversial, but highly relevant subject in patients infected with hepatitis B virus (HBV). We aimed to explore the related factors for safe NAs cessation. Methods This multicenter prospective cohort study. Overall, 139 initially HBV e antigen (HBeAg)-positive meeting stopping criteria were included 12 hospitals China. Enrolled ceased followed up every 3 months 24 or until clinical relapse...
It is unknown whether dynamic changes of liver stiffness measurement (LSM) can predict the reversibility fibrosis. Therefore, we evaluated utility LSM in predicting histological fibrosis patients with chronic hepatitis B (CHB) on antiviral therapy. In a prospective cohort CHB treated entecavir, virological and biochemical along were measured at baseline every 6 months. Liver biopsies conducted month 18 treatment. Fibrosis regression was defined by following two criteria: (a) Ishak score...
Abstract Gut microbes play an important role in the development of host B cells. It has been controversial whether GALT is site cells pigs. By investigating relationship between gut and piglets, we found, to our knowledge for first time, that early exist lamina propria (LP) pigs at different ages. We further used Lactobacillus rhamnosus GG (LGG) treat piglets. The results showed LGG promotes lineage, affects composition Ig CDR3 repertoires cells, production IgA intestinal LP. Additionally,...