A5055455306- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Hepatitis B Virus Studies
- Hematopoietic Stem Cell Transplantation
- Hepatitis C virus research
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Frailty in Older Adults
- Esophageal Cancer Research and Treatment
- Pediatric Urology and Nephrology Studies
- Cancer Treatment and Pharmacology
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2025
Beijing Hospital
2016-2025
Peking University
2011-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Xiamen University
2013-2025
Peking University Third Hospital
2021-2025
Ministry of Education of the People's Republic of China
2025
Tianjin Medical University General Hospital
2010-2024
Beijing YouAn Hospital
2010-2024
ABSTRACT Background This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in era novel agents. Methods A total 112 high‐risk MM were included (single ASCT, (n = 57) or 55) this retrospective multicenter study. Responses outcomes evaluated. Results At 100 days after ASCT1 ASCT2, 36 (63.2%) 45 (81.8%) achieved sCR/CR, 16 (28.1%) 7 (12.7%) VGPR, 5 (8.8%) 1 (1.8%) patient PR, respectively, cohorts....
Abstract Purpose: Tumor antigen–loaded dendritic cells (DC) are believed to activate antitumor immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)–blocking antibodies should release a key negative regulatory pathway on cells. The combination was tested in phase I clinical trial patients with advanced melanoma. Experimental Design: Autologous DC were pulsed MART-126-35 peptide administered dose escalation of the CTLA4-blocking antibody tremelimumab. Sixteen accrued five...
Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis. Evidence has shown that antiviral therapy can reverse liver or even early cirrhosis caused by hepatitis B virus. However, current evaluation systems mainly focus on severity of, but not in, fibrosis. Here, we propose a new classification to evaluate in quality fibrosis, namely: predominantly progressive (thick/broad/loose/pale septa with inflammation); predominately regressive...
The main obstacle of multiple myeloma (MM) therapy is the compromised immune microenvironment, which leads to MM relapses and extramedullary disease progression. In this study, a novel strategy reported enhanced immunogenic cell death (ICD) immunotherapy with aggregation-induced emission (AIE) photosensitizer-loaded bovine serum albumin (BSA) nanoparticles (referred as BSA/TPA-Erdn), can activate T cells, convert cold tumor hot, reverse senescence restore microenvironment for treatment....
Background: Sepsis remains a significant challenge in patients with major trauma the ICU. Early detection and treatment are crucial for improving outcomes reducing mortality rates. Nonetheless, clinical tools predicting sepsis among limited. This study aimed to develop validate an artificial intelligence (AI) platform risk of trauma. Methods: involved 961 patients, prospective analysis data from 244 at our hospital retrospective 717 extracted database United States. The constituted model...
Abstract Backgroud Intervertebral disc degeneration (IDD) is one of the common degenerative diseases. Due to ethical constraints, it difficult obtain sufficient research on humans, so use an animal model IDD very important clarify pathogenesis and treatment mechanism disease. Methods In this study, thirty 2‐month‐old mice were selected for operation establish a coccygeal model. The distal tail portion (beyond 17th vertebra) small piece skin above 8th vertebra excised, two incisions brought...
AIM:To evaluate the diagnostic value of glypican-3 (GPC3) in serum and liver for primary hepatocellular carcinoma (HCC). METHODS:Serum levels GPC3 α-fetoprotein (AFP) were measured 75 patients with HCC 32 cirrhosis.Expression AFP 58 12 cirrhotic specimens was detected immunohistochemical staining. RESULTS:When cut-off set at 300 ng/L, its sensitivity specificity 47.0% 93.5%, respectively.Among 14 stage according to Barcelona Clinic Liver Cancer staging system, level higher than ng/L 50%...
Abstract We present the results of a comparative gene expression analysis 15 metastases (10 regressing and 5 progressing) obtained from 2 melanoma patients with mixed response following different forms immunotherapy. Whole genome transcriptional clearly indicate that regression is due to an acute immune rejection mediated by upregulation genes involved in antigen presentation interferon (STAT‐1/IRF‐1) all both patients. In contrast, progressing showed low transcription levels these pathways....
Abstract Background GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression. Results Here, we explored xenograft/VACV/host interactions in vivo adopting organism-specific expression arrays and tumor cell/VACV vitro comparing VACV replication patterns. There were no clear-cut differences among responding non-responding tumors, however, rejection was associated with activation of...
The aim of the study was to explore clinical significance let-7 expression in hepatocellular carcinoma (HCC). A PCR array conducted screen for early-stage HCC. Next, deregulation confirmed by quantitative real-time RT-PCR (qRT-PCR) another set liver tissues, including normal control (NC), chronic hepatitis (CH), cirrhosis (LC), HCC, and adjacent nontumor (NT) tissues. In addition, as potential target mRNA let-7, alpha 2(I) collagen (COL1A2) also quantified above Finally, an association...
Immune effector cells in patients with multiple myeloma (MM) are at the forefront of many immunotherapy treatments, and several methods have been developed to fully utilise antitumour potential immune cells. T NK cell-derived lymphocytes both expressed activating receptor group 2 member D(NKG2D). This can identify eight distinct NKG2D ligands (NKG2DL), including major histocompatibility complex class I (MHC) chain-related protein A B (MICA MICB). Their binding triggers roles NKG2DL is...
Background Serum aspartate aminotransferase (AST) to alanine (ALT) ratio (AAR) is one of the most frequent indicators discriminate fibrosis and cirrhosis. However, results remained controversial. The aim this study was evaluate predictive effect AAR on hepatitis B virus (HBV)-related cirrhosis development. Method A retrospective cohort conducted based 1754 chronic HBV-infected patients. Clinical variables at their initial visit follow-up data were collected. Cox proportional hazards model...
Abstract Purpose: The purpose of this study was to investigate the remodeling multiple myeloma microenvironment after B-cell maturation antigen (BCMA)–targeted chimeric receptor T (CAR-T) cell therapy. Experimental Design: We performed single-cell RNA sequencing on paired bone marrow specimens (n = 14) from seven patients with before (i.e., baseline, “day −4”) and 28”) lymphodepleted BCMA CAR-T Results: Our analysis revealed heterogeneity in gene expression profiles among cells, even those...
The optimal preemptive therapy for Epstein–Barr virus (EBV)‐associated diseases remains under discussion. We developed a stepwise (antiviral agents and reduction of immunosuppressants [RI] followed by rituximab) EBV viremia, based on duration viremia changes viral loads. blood EBV‐DNA loads were regularly monitored quantitative real‐time polymerase chain reaction in 251 recipients undergoing allogeneic stem cell transplantation. 3‐year cumulative incidence EBV‐associated 31.1% ± 3.1% 15.6%...
Current widely used semiquantitative histological assessment methods are insensitive to identify subtle changes of liver fibrosis. Therefore, precisely assess therapeutic efficacy on chronic hepatitis B (CHB), we explored the utility qFibrosis (a fully-quantitative morphometric method employing second harmonic generation/two photon excitation fluorescence) in fibrosis evaluation. Fibrosis were evaluated by Ishak scoring and CHB patients with paired biopsies before after 78 weeks' antiviral...
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes cancer‐related death worldwide and lacks biomarkers for personalized therapy. Herein, it reported that MCB1 could be a novel oncofetal protein upregulated in preneoplastic lesions serum early HCC patients. Functional studies reveal modulated p53 degradation to promote T‐IC generation drive initiation. Furthermore, MCB1/p53 axis shown determine responses hepatoma cells conventional chemotherapeutics predict transcatheter...
Fundamental studies have suggested that matrix metalloproteinases-7 (MMP-7) expression is associated with chemoresistance and constitutes a prognostic factor in several solid tumors. The present study assessed the predictive value of MMP-7 tumors patients advanced non-small cell lung cancer (NSCLC) treated platinum-based chemotherapy. In total, 159 stage III IV NSCLC were retrospectively enrolled. Immunohistochemistry was performed to evaluate MMP-7, apoptosis-related proteins Bcl-2, Bax,...