A5101647699- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Melanoma and MAPK Pathways
- Pelvic and Acetabular Injuries
- HER2/EGFR in Cancer Research
- Management of metastatic bone disease
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Kinase Regulation and GTPase Signaling
- Bone health and osteoporosis research
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Scoliosis diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Neuroendocrine Tumor Research Advances
- Bone and Joint Diseases
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Chronic Kidney Disease and Diabetes
Capital Medical University
2016-2025
Anhui Medical University
2010-2025
Beijing Jishuitan Hospital
2020-2025
Peking University
2020-2025
Beijing Shijitan Hospital
2022-2025
First Affiliated Hospital of Anhui Medical University
2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2022-2024
China Medical University
2024
Beijing Friendship Hospital
2015-2024
Sichuan University
2016-2024
ABSTRACT Background This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in era novel agents. Methods A total 112 high‐risk MM were included (single ASCT, (n = 57) or 55) this retrospective multicenter study. Responses outcomes evaluated. Results At 100 days after ASCT1 ASCT2, 36 (63.2%) 45 (81.8%) achieved sCR/CR, 16 (28.1%) 7 (12.7%) VGPR, 5 (8.8%) 1 (1.8%) patient PR, respectively, cohorts....
Abstract Tumor metastasis is the major cause of morbidity and mortality in patients with breast cancer. It critical to identify enabling genes understand how they are responsible for inducing specific aspects metastatic phenotype allow improved clinical detection management. Protein kinase Cε (PKCε), a member family serine/threonine protein kinases, transforming oncogene that has been reported be involved cell invasion motility. In this study, we investigated role PKCε cancer development...
Nasal administration has emerged as a promising and attractive route for vaccination, especially the prophylaxis of respiratory diseases. Our previous studies have shown that severe acute syndrome coronavirus (SARS-CoV) virus-like particles (VLPs) can be assembled using recombinant baculovirus (rBV) expression system such VLPs induce specific humoral cellular immune responses in mice after subcutaneous injection. Here, we investigated mucosal to SARS-CoV mouse model. Mice were immunized...
Historically well-known tumor-promoting gene family plays a key role in cell identity regulation small lung cancer.
Abstract Over 70% of patients with head and neck squamous cell carcinoma (HNSCC) present locoregionally advanced stage III IV disease. In spite aggressive therapy, locoregional disease recurs in 60% metastatic develops 15% to 25% causing a major decline quality length life. Therefore, there is need identify understand genes that are responsible for inducing an HNSCC phenotype. Evidence has shown protein kinase C (PKC) ε transforming oncogene may play role progression. this study, we...
Abstract Both pro‐inflammatory cytokines and anti‐inflammatory generated by chondrocytes play essential roles in the process of Rheumatoid arthritis osteoarthritis (OA). Bornyl acetate is main volatile constituent numerous conifer oils some Chinese traditional herbs, which has displayed an effect before. In this study, we found that bornyl elevates expression IL‐11 at both mRNA protein levels. Interestingly, our results indicated IL‐1β‐mediated up‐regulation IL‐6, IL‐8, MMP‐1, MMP‐13 was...
Comprehensive analysis of serum lipidomics is important for the treatment and prevention type 2 diabetes (T2DM). The purpose this study was to provide a profile lipid changes in T2DM patients identify potential biomarkers. In study, we collected clinical physiological parameters determined profiles 30 matched healthy volunteers using UPLC-MS method. T test multivariate statistical analyses were used candidate predictors GraphPad Prism 9.5 software MetaboAnalyst 5.0 online platform. Based on...
ABSTRACT Circulating cell‐free DNA (cfDNA) is a large molecule that plays central role in the pathogenesis of SLE. It target antigen autoantibodies and main component immune complexes. Due to differences content cfDNA detected different studies, cannot be used as strong diagnostic basis for SLE at present. As an active cfDNA, correlation between double‐stranded (dsDNA) has not been fully studied. The detection dsDNA may provide more accurate diagnosis treatment SLE, in‐depth study patients...
As environmentally friendly pile foundations with small diameters and higher slenderness ratios, micropiles are widely used in fields such as transmission line engineering building reinforcement. However, the available research has primarily focused on their bearing performance under compressive horizontal loads, there is insufficient predicting uplift capacity of micropiles. This study investigated load transfer mechanism behavior surrounding soil using model tests finite element...
Rationale: The current molecular classification of small-cell lung cancer (SCLC) on the basis expression four lineage transcription factors still leaves its major subtype SCLC-A as a heterogeneous group, necessitating more precise characterization subclasses. Objectives: To refine SCLC with epigenomic profiles and to identify features redefined subtypes. Methods: We performed unsupervised clustering 25 cell lines. Functional significance NKX2-1 (NK2 homeobox 1) was evaluated by growth,...
Purpose: Amino acids are the important metabolites in body and play a crucial role biological processes. The purpose of this study is to provide profile amino change serum T2DM patients identify potential biomarkers. Patients Methods: In study, we quantitatively determined acid profiles 30 healthy volunteers. T test multivariate statistical analysis were used candidate biomarkers with GraphPad Prism 9.5 software MetaboAnalyst 5.0 on-line platform. Results: Thirty-four quantified, 19 levels...
Abstract Purpose: c-Src has been shown to play a pivotal role in breast cancer progression, metastasis, and angiogenesis. In the clinic, however, limited efficacy high toxicity of existing inhibitors have tempered enthusiasm for targeting c-Src. We developed novel inhibitor (UM-164) that specifically binds DFG-out inactive conformation its target kinases. hypothesized binding kinase would lead improved pharmacologic outcomes by altering noncatalytic functions targeted Experimental Design:...
A sandwich vertebra is formed after multiple osteoporotic vertebral fractures treated by percutaneous vertebroplasty, which has a risk of developing new fractures. The purpose our study was to (i) investigate the occurrence in cement augmentation procedures and (ii) evaluate clinical outcomes prophylactic reinforcement applied with resorbable bone cement. From June 2011 2014, we analysed 55 patients at least one vertebrae vertebroplasty. Eighteen were vertebroplasty strengthen as prevention...
Necroptosis is a regulated cell death mechanism. However, it unknown whether necroptosis involved in the of tumor necrosis factor-α (TNF-α)-treated osteoblasts. Therefore, we conducted study with TNF-α, Nec-1 (a specific inhibitor necroptosis), and Z-IETD-FMK apoptosis) to determine plays role TNF-α-treated osteoblast line MC3T3-E1. Cell viability, death, lactate dehydrogenase (LDH) release were assayed evaluate cytotoxicity. Specific marker proteins receptor interacting protein kinase...
To observe optical coherence tomography angiography (OCTA) images during follow-up of choroidal neovascularization (CNV) caused by pathological myopia (PM) or idiopathy and discuss OCTA's clinical applications Patients with CNV PM idiopathic (ICNV) were recruited prospectively from the Department Ophthalmology, West China Hospital March 2015 to June 2015. Intravitreal injections Ranibizumab conducted on all patients repeated treatments performed based examinations follow-up. received OCTA...