A5101914253- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Advanced MRI Techniques and Applications
- Immune Cell Function and Interaction
- Aquaculture disease management and microbiota
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- Cannabis and Cannabinoid Research
- Chronic Kidney Disease and Diabetes
- Respiratory Support and Mechanisms
- Diabetes and associated disorders
- Management of metastatic bone disease
- RNA Interference and Gene Delivery
- Food composition and properties
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Circular RNAs in diseases
- Advanced Fiber Laser Technologies
Taipei Medical University
2024-2025
Shandong University
2015-2024
Qilu Hospital of Shandong University
2011-2024
Shandong University of Traditional Chinese Medicine
2023
Daping Hospital
1994-2022
Army Medical University
2005-2022
Shandong Provincial Hospital
2013-2022
Anhui Provincial Hospital
2022
Shandong First Medical University
2021-2022
Army Medical College
2021
Cardiovascular disease (CVD) is now the most prevalent and debilitating affecting Chinese population. The goal of present manuscript was to analyse cardiovascular risk factors prevalence non-fatal CVDs from data gathered 2007-2008 China National Diabetes Metabolic Disorders Study.A nationally representative sample 46 239 adults, 20 years age or older, randomly recruited using a multistage stratified design method. Lifestyle factors, diagnosis CVD, stroke, diabetes, family history each...
Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K 2p 1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection of chemotherapy agent paclitaxel time‐dependently downregulates expression mRNA and its coding protein DRG neurons. Rescuing this downregulation mitigates development maintenance paclitaxel‐induced mechanical...
Abstract Background c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it reported that overexpression c-Jun in cancer cell line MCF-7 resulted increased AP-1 activity, motility and invasiveness the cells vitro tumor formation nude mice. However, role metastasis human vivo is currently unknown. Methods To further investigate direct involvement tumorigenesis metastasis, present study, effects were studied both Results Ectopic promoted growth a significant...
Abstract An alternative adaptive-immune system is present in the most basal vertebrates—lampreys and hagfish—the only surviving jawless vertebrates. These eel-like fish use leucine-rich repeat–based receptors for Ag recognition instead of Ig-based used jawed We report that Japanese lamprey (Lampetra japonica), variable lymphocyte receptor (VLR)B interacts with C1q C3 proteins to mediate complement-dependent cytotoxicity bacteria tumor cells. The immune-based lysis involves deposition VLRB...
The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series experiments both vitro vivo were used to characterize promotive NPC tumorigenesis identify prolyl isomerase Pin1 as novel regulator at post-transcription. First, we found that overexpression promoted colony formation NPC. However, high protein level not resulted from mRNA level....
Objective The oxidative balance score (OBS) is important for determining the cause of obesity and its complications. We aimed to evaluate association between OBS other segmental body composition parameters among young middle-aged U.S. adults. Methods 9,998 participants from National Health Nutrition Examination Survey 2011–2018 were included. Lean mass percentage (LM%) FM% evaluated by dual-energy x-ray absorptiometry. Obesity was defined as ≥25% in men ≥ 35% women. scored 5 pro-oxidant 21...
Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and more severe injuries showed higher longer durations of levels. Although the increase amplitude was similar between two groups, duration TBI. There were no significant differences MPT regard to ALI status, but levels TBI-ALI...
: Accumulating evidence has supported that mild elevated total bilirubin exerts antioxidant and anti-inflammatory properties in multiple metabolic diseases. We aimed to explore the association of circulating concentration with non-alcoholic fatty liver disease (NAFLD) risk all-cause mortality examined potential nonlinear relationship between them. used nationally representative data from National Health Nutrition Examination Survey (NHANES). NAFLD was assessed using index (FLI) United States...
The A2A receptor agonist, regadenoson, is increasingly used as a vasodilator during nuclear myocardial perfusion imaging. Regadenoson administered single, fixed dose. Given the frequency of obesity in patients with symptoms heart disease, it important to know whether dose regadenoson produces maximal coronary hyperemia subjects widely varying body size. Thirty (12 female, 18 male, mean BMI 30.3 ± 6.5, range 19.6–46.6) were imaged on 3T magnetic resonance scanner. Imaging saturation recovery...
Glabridin, an isoflavone isolated from licorice, owns a variety of pharmacological effects. Several reports have demonstrated that glabridin could regulate multiple cellular signaling pathways to inhibit the progression cancer. However, target proteins not been elucidated yet. We used shape screening and induced fit docking screen protein data bank against glabridin. Braf MEK1/2, important intermediate molecules braf/MEK cascade, were identified as potential targets The experimental showed...
To investigate the toileting behaviours that female nurses used to empty their bladders, health beliefs related behaviour and relationships between based on Health Belief Model.A stratified cluster sampling strategy was recruit 636 from three tertiary hospitals in China. Reliable valid questionnaires were assess nurses' behaviour. The structural equation model applied explore belief constructs behaviour.The most common unhealthy of delayed voiding. More than half (53.6%) often or always...