A5100636401- Cytomegalovirus and herpesvirus research
- Analytical chemistry methods development
- Pesticide Residue Analysis and Safety
- Viral-associated cancers and disorders
- Electrochemical sensors and biosensors
- Herpesvirus Infections and Treatments
- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Virology and Viral Diseases
- Graphene and Nanomaterials Applications
- Forensic Toxicology and Drug Analysis
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Asthma and respiratory diseases
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Electrochemical Analysis and Applications
- Carbon and Quantum Dots Applications
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Chromatography
- Lysosomal Storage Disorders Research
- Immunotherapy and Immune Responses
Guangzhou Medical University
2025
Institute of Vegetables and Flowers
2015-2024
Chinese Academy of Agricultural Sciences
2015-2024
Huazhong University of Science and Technology
2014-2024
Wuhan University
1998-2024
Ministry of Agriculture and Rural Affairs
2018-2024
Nanjing Medical University
2010-2024
Hangzhou First People's Hospital
2024
Westlake University
2024
Shenyang Agricultural University
2024
Emerging genetic and clinical evidence suggests a link between Gaucher disease the synucleinopathies Parkinson dementia with Lewy bodies. Here, we provide that mouse model of (Gba1(D409V/D409V)) exhibits characteristics synucleinopathies, including progressive accumulation proteinase K-resistant α-synuclein/ubiquitin aggregates in hippocampal neurons coincident memory deficit. Analysis homozygous heterozygous (Gba1(D409V/+) Gba1(+/-)) mice indicated these pathologies are result combination...
Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for development of effective strategies treating tumors and chronic infections. The molecular processes that occur in responder are suppressed Treg unclear. Here we show human initiate DNA damage effector caused metabolic competition during cross-talk, resulting senescence functional changes molecularly distinct from anergy exhaustion. ERK1/2 p38 signaling cooperate with STAT1 STAT3 to control Treg-induced...
Systemic inflammatory illnesses (such as sepsis) are marked by degradation of the endothelial glycocalyx, a layer glycosaminoglycans (including heparan sulfate, chondroitin and hyaluronic acid) lining vascular lumen. We hypothesized that different pathophysiologic insults would produce characteristic patterns released glycocalyx fragments. collected plasma from healthy donors well subjects with respiratory failure due to altered mental status (intoxication, ischemic brain injury), indirect...
Beginning in June of 2019, there was a marked increase reported cases serious pulmonary injury associated with vaping. The condition, referred to as e-cigarette or vaping product use-associated lung (EVALI), does not appear involve an infectious agent; rather, chemical adulterant contaminant fluids is suspected. In August the Wadsworth Center began receiving vaporizer cartridges recovered from patients EVALI for analysis. Having no priori information what might be cartridges, we employed...
Imidacloprid is one of the most commonly used insecticides for managing pests, thus, improving quality and yield vegetables. The abuse/misuse imidacloprid contaminates environment threatens human health. To reduce risk, a colorimetric enzyme-linked immunoassay assay (Co-ELISA) chemiluminescence (Cl-ELISA) were established to detect residues in linear range Co-ELISA ranged between 1.56 μg/L 200 with limit detection (LOD) μg/L. values Cl-ELISA 0.19 25 an LOD μg/L, which are lower than those...
Abstract Aims Excessive influx of manganese (Mn) into the brain across blood–brain barrier induces neurodegeneration. CYP1B1 is involved in metabolism arachidonic acid (AA) that affects vascular homeostasis. We aimed to investigate effect on Mn‐induced neurotoxicity. Method Brain Mn concentrations and α‐synuclein accumulation were measured wild‐type knockout mice treated with MnCl 2 (30 mg/kg) biotin (0.2 g/kg) for 21 continuous days. Tight junctions oxidative stress analyzed hCMEC/D3...
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting all the organ systems. Apart from genetic and environmental factors, autoantibody immune complex deposition as well cytokine imbalances contribute to dysfunction. Interleukin‑9 (IL-9) a T cell-derived factor preferentially expressed by CD4+ cells it has been characterized in human murine IL-9 targets lymphoid, myeloid mast cell lineages, likely development allergic diseases such asthma, arthritis,...
Neuropathic Gaucher disease (nGD), also known as type 2 or 3 disease, is caused by a deficiency of the enzyme glucocerebrosidase (GC). This impairs degradation glucosylceramide (GluCer) and glucosylsphingosine (GluSph), leading to their accumulation in brains patients mouse models disease. These accumulated substrates have been thought cause severe neuropathology early death observed with nGD models. Substrate evident at birth both humans affected most Current treatment non-nGD relies on...
Fibrates, the ligands of peroxisome proliferator-activated receptor- α, have been shown to a renal protective action in diabetic models disease, but mechanisms underlying this effect are unknown. In present study, we sought investigate greater detail fenofibrate and its mechanism on inflammation tubulointerstitial fibrosis an animal model type 2 diabetes mellitus. Twelve-week-old non-diabetic Zucker lean (ZL) fatty (ZD) rats were treated with vehicle or for 10 weeks. mRNA protein analyses...
The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there no effective therapies. A potential approach is substrate reduction therapy using inhibitors glucosylceramide synthase (GCS) to decrease the synthesis and related glycosphingolipids that accumulate in lysosomes. Genz-529468, blood-brain barrier-permeant iminosugar-based GCS inhibitor, was used evaluate this concept mouse model Sandhoff disease, accumulates glycosphingolipid GM2 visceral organs...
Hypoxia was shown to be associated with an increased risk of Alzheimer's disease (AD). The effects hypoxia on the development AD pathology and spatial memory ability possible molecular mechanisms remain poorly understood. In this study, we demonstrate that rats exposed a hypoxic condition (10% oxygen concentration) for 1, 2, 4 8 weeks (6 h each day) displayed impairment tau phosphorylation at Ser198/199/202, Thr205, Ser262, Ser396 Ser404 in hippocampus. Concomitantly, levels...