A5045720115- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Genetic factors in colorectal cancer
- biodegradable polymer synthesis and properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
- Fibroblast Growth Factor Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Proteoglycans and glycosaminoglycans research
- Immune Response and Inflammation
- Natural Fiber Reinforced Composites
- COVID-19 Clinical Research Studies
Peking University
2016-2025
Tongji University
2024-2025
Tongji Hospital
2024-2025
First Affiliated Hospital of Soochow University
2014-2025
Soochow University
2014-2025
China Agricultural University
2025
Qingdao Municipal Center for Disease Control and Prevention
2024-2025
Chinese Academy of Sciences
2004-2024
Wuxi Fourth People's Hospital
2014-2024
BOE Technology Group (China)
2023-2024
In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The spatial temporal expression patterns FGFRs the ability specific ligand-receptor pairs to actively signal important regulating activity in a variety biological processes. signaling is regulated binding specificity ligands modulated extrinsic cofactors such as heparan sulfate proteoglycans. previous studies, we have...
Several recent clinical studies have shown that serum homocysteine (Hcy) levels are positively correlated, while vitamin B12 (B12) and folate negative with non-alcoholic steatohepatitis (NASH) severity. However, it is not known whether hyperhomocysteinemia (HHcy) plays a pathogenic role in NASH.We examined the effects of HHcy on NASH progression, metabolism, autophagy dietary genetic mouse models, patients, primates. We employed (Fol) to reverse features mice cell culture.Serum Hcy...
Perichondrium in fetal limb is composed of undifferentiated mesenchymal cells. However, the multipotency cells this region and role perichondrium bone marrow formation are not well understood. In report, we purified characterized perichondrial using a monoclonal antibody against activated leukocyte cell adhesion molecule (ALCAM) investigated hematopoietic formation. ALCAM expressed on cells, endothelial stromal stem mediates homophilic (ALCAM–ALCAM)/heterophilic (ALCAM-CD6) adhesion. Here...
The elimination process of systemically administered small interfering RNA (siRNA) was investigated by using siRNA labeled with an infrared fluorescent dye. A novel pathway identified. In this pathway, liver-enriched is secreted into the gallbladder and then emptied intestine. Blocking resulted in absence fluorescence within intestine, greatly enhanced accumulation liver at same time. Furthermore, we demonstrated that delivery carriers play essential role distribution elimination,...
Obesity is a major risk factor for type 2 diabetes and cardiovascular diseases. And overnutrition leading cause of obesity. After most nutrients are ingested, they absorbed in the small intestine. Signals from β-catenin essential to maintain development intestine homeostasis. In this study, we used hyperphagia db/db obese mouse model high-fat diet (HFD)-induced obesity investigate effects on intestinal function signaling. The protein was upregulated along with inactivation glycogen synthase...
Although conventional genetic modification approaches for protein knockdown work very successfully due to the increasing use of CRISPR/Cas9, effective techniques achieving depletion in adult animals, especially large animals such as non-human primates, are lacking. Here, we report a chemical approach based on PROTACs technology that efficiently and quickly knocks down FKBP12 (12-kDa FK506-binding) globally vivo. Both intraperitoneal oral administration led rapid, robust, reversible...
Abstract Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction an even higher risk of the occurrence diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates (NHPs) models 121 vaccinated NHPs 2020 to 2023 patients. Multi-label immunofluorescence revealed direct infection both exocrine endocrine cells by virus humans. Minor limited phenotypic histopathological changes were...
Introduction Wound healing poses a clinical challenge in diabetes mellitus (DM) due to compromised host immunity. CD64, an IgG-binding Fcgr1 receptor, acts as pro-inflammatory mediator. While its presence has been identified various inflammatory diseases, specific role wound healing, especially DM, remains unclear. Objectives We aimed investigate the involvement of CD64 diabetic using DM animal model with KO mice. Methods First, we compared expression chronic skin ulcers from human and...
The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 upregulated human colorectal cancer promotes proliferation when overexpressed a colon line. interacts with mitochondrial Ca2+ uniporter (MCU) to promote by increasing uptake energy metabolism. ubiquitination site of (RIPK1-K377) was critical this interaction MCU function promoting proliferation. These findings identify the...
Understanding of the RNA editing process has been broadened considerably by next generation sequencing technology; however, several issues regarding this regulatory step remain unresolved – strategies to accurately delineate editome, mechanism which its profile is maintained, and evolutionary functional relevance. Here we report an accurate quantitative editome for rhesus macaque, a close relative human. By combining genome transcriptome multiple tissues from same animal, identified 31,250...
Obesity is characterized by aberrant fat accumulation. However, the intracellular signaling pathway that senses dietary and leads to storage remains elusive. Here, we have observed levels of histone deacetylase 6 (HDAC6) related family member HDAC10 are markedly reduced in adipose tissues obese animals humans. Mice with adipocyte-specific depletion Hdac6 exhibited increased accumulation insulin sensitivity. In normal adipocytes, found reversal P300/CBP-associated factor-induced...
Background It is crucial to comprehend the interplay between air pollution and meteorological conditions in relation population health within framework of "dual-carbon" targets. The purpose this study was investigate impact intricate environmental factors, encompassing both atmospheric pollutants, on respiratory disease (RD) mortality Qingdao, a representative coastal city China. Methods RD cases were collected from Chronic Disease Surveillance Monitoring System Qingdao during Jan 1st, 2014...
Abstract Background We observed an increased presence of succinate dehydrogenase complex subunit A (SDHA), a mitochondrial enzyme, in breast cancer (BC), which contributes to its proliferation. While SDHA deficiency has been extensively researched rare disorders, the upregulation and impact on BC remain understudied. The aim this study is investigate role BC. Methods mRNA expression was analyzed from TCGA, clinical tissues various cell lines via qPCR. Immunohistochemistry also applied detect...
Abstract Leukocyte interactions with vascular endothelium during inflammation depend on cascades of adhesion molecule engagement, particularly selectin-mediated leukocyte rolling. rolling is also facilitated by members the integrin and Ig families. Specifically, velocities are significantly increased in ICAM-1-deficient mice, ICAM-1 expression required for optimal P- L-selectin-mediated Elimination L-selectin-deficient mice reduces Whether disrupted L-selectin double-deficient...
Abstract Lymphocyte migration into lymphoid organs is regulated by tissue-specific adhesion molecules such as L-selectin and the α4β7 integrin. Whether also regulates lymphocyte subset-specific specific tissues was examined in this study comparing of CD4+ T cells, CD8+ B cells from L-selectin-deficient wild-type mice. were predominant subset entering PLN, MLN, Peyer’s patches, spleen during short term (1-h) assays. However, both cell entries patches dramatically impaired (73–98%) loss...
Short bowel syndrome is an acquired condition in which the length of small intestine insufficient to perform its normal absorptive function. Current therapies are limited as developmental mechanisms that normally regulate elongation poorly understood. Here, we identify Fgf9 important epithelial-to-mesenchymal signal required for proper intestinal morphogenesis. Mouse embryos lack either or mesenchymal receptors contained a disproportionately shortened intestine, decreased proliferation,...