A5047141065- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Pharmacogenetics and Drug Metabolism
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Lung Cancer Treatments and Mutations
- High-pressure geophysics and materials
- Lung Cancer Research Studies
- COVID-19 epidemiological studies
- Geological and Geochemical Analysis
- COVID-19 Clinical Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Pancreatitis Pathology and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Hepatitis C virus research
- Computational Drug Discovery Methods
- COVID-19 Pandemic Impacts
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
- Hedgehog Signaling Pathway Studies
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Corporate Finance and Governance
Duke University
2016-2025
Durham VA Medical Center
2018-2025
Tokyo Medical and Dental University
2024
Dokkyo Medical University
2015-2024
Duke Medical Center
2011-2023
Duke University Hospital
2009-2023
University of Minnesota
2010-2023
Yamagata University
1992-2023
The University of Tokyo
2022-2023
Waseda University
2004-2023
The rising incidence of obesity and diabetes coincides with a marked increase in fructose consumption. Fructose consumption is higher individuals nonalcoholic fatty liver disease (NAFLD) than age-matched body mass index (BMI)-matched controls. Because elicits metabolic perturbations that may be hepatotoxic, we investigated the relationship between severity NAFLD. We studied 427 adults enrolled NASH Clinical Research Network for whom Block food questionnaire data were collected within 3...
The purpose of this study was to validate the Japanese version Utrecht Work Engagement Scale (UWES‐J). Employees from three independent samples completed questionnaire (total N = 2,334). Confirmatory factor analyses using multiple‐group method revealed that, instead original three‐factor model, a one‐factor model that assumes all engagement items load on one single fitted data. Moreover, structure invariant across samples. Internal consistency scale sufficiently high (α= .92) and test–retest...
Estrogens inhibit stellate cell activation and fibrogenesis. Thus, gender reproductive states may influence the degree of fibrosis in patients with nonalcoholic steatohepatitis (NASH). To investigate association between gender, menopause, severity liver NASH, we analyzed 541 adult enrolled from our Duke Liver Clinics (n = 338) Metabolic Weight Loss Surgery Program 203) who had a histologic diagnosis NASH. Multiple ordinal logistic regression models were used to assess fibrosis. Overall, men,...
Distinguishing drug-induced liver injury (DILI) from idiopathic autoimmune hepatitis (AIH) can be challenging. We performed a standardized histologic evaluation to explore potential hallmarks differentiate AIH versus DILI. Biopsies patients with clinically well-characterized DILI [n = 35, including 19 hepatocellular (HC) and 16 cholestatic/mixed (CS)] (n 28) were evaluated for Ishak scores, prominent inflammatory cell types in portal intra-acinar areas, the presence or absence of...
Clinicians rely upon the severity of liver fibrosis to segregate patients with well-compensated nonalcoholic fatty disease (NAFLD) into subpopulations at high- versus low-risk for eventual liver-related morbidity and mortality. We compared hepatic gene expression profiles in NAFLD identify processes that distinguish two groups hence might be novel biomarkers or treatment targets. Microarray analysis was used characterize percutaneous biopsies from low-risk, “mild” (fibrosis stage 0–1; n =...
The impact of the drastic reduction in travel volume within mainland China January and February 2020 was quantified with respect to reports novel coronavirus (COVID-19) infections outside China. Data on confirmed cases diagnosed were analyzed using statistical models estimate three epidemiological outcome measures: (i) number exported cases, (ii) probability a major epidemic, (iii) time delay epidemic. From 28 7 2020, we estimated that 226 (95% confidence interval: 86,449) prevented,...
A total of 565 Japanese citizens were evacuated from Wuhan, China to Japan. All passengers screened for symptoms and also undertook reverse transcription polymerase chain reaction testing, identifying 5 asymptomatic 7 symptomatic testing positive 2019-nCoV. We show that the screening result is suggestive ratio at 41.6%.
INTRODUCTION There are currently more than 1000 prescription medications available for use in the United States and 100,000 over‐the‐counter herbal dietary supplements (HDS) purchase retail stores online. In addition, average adult American receives six per year.1,2 Many of these drugs HDS products have been implicated as causes DILI. Furthermore, DILI is a leading reason regulatory actions regarding development well those marketplace.1 Confidently establishing diagnosis difficult because...
Several recent clinical studies have shown that serum homocysteine (Hcy) levels are positively correlated, while vitamin B12 (B12) and folate negative with non-alcoholic steatohepatitis (NASH) severity. However, it is not known whether hyperhomocysteinemia (HHcy) plays a pathogenic role in NASH.We examined the effects of HHcy on NASH progression, metabolism, autophagy dietary genetic mouse models, patients, primates. We employed (Fol) to reverse features mice cell culture.Serum Hcy...
Abstract: Aim: To determine whether serum hyaluronic acid reliably predicts the severity of hepatic fibrosis in patients with non‐alcoholic fatty liver disease (NAFLD). Methods: We studied 79 histologically confirmed NAFLD. Hyaluronic was measured obtained at time biopsy. Severity staged based on Brunt's classification. The prediction levels for were determined by area under receiver operating characteristic curve (AUC). Results: logarithm significantly different among stages ( P <0.0001,...
The Hedgehog (HH)-signaling pathway mediates several processes that are deregulated in patients with metabolic syndrome (e.g., fat mass regulation, vascular/endothelial remodeling, liver injury and repair, carcinogenesis). severity of nonalcoholic fatty disease (NAFLD) generally correlate. Therefore, we hypothesized the level HH-pathway activation would increase parallel damage NAFLD. To assess potential correlations between known histologic clinical predictors advanced activation,...
The incidence and risk factors of nonalcoholic fatty liver disease (NAFLD) have never been prospectively determined. To determine the frequency NAFLD chronological ordering between NAFLD, weight gain, features insulin resistance, a historical cohort study was conducted in Japanese workplace. A free previous injury, alcohol consumption more than 140 g/wk, hepatitis B or C infection (529 1,537 subjects), subcohort 287 subjects resistance–related were identified. Elevated aminotransferases...