Xiao Chen

ORCID: 0000-0001-9432-015X
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Research Areas
  • Atherosclerosis and Cardiovascular Diseases
  • Molecular Sensors and Ion Detection
  • Renin-Angiotensin System Studies
  • Tryptophan and brain disorders
  • Computational Drug Discovery Methods
  • Muscle Physiology and Disorders
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Mercury impact and mitigation studies
  • Neurological Disease Mechanisms and Treatments
  • Cancer Research and Treatments
  • Neuroscience and Neuropharmacology Research
  • Aquaculture Nutrition and Growth
  • Advanced Battery Technologies Research
  • Influenza Virus Research Studies
  • Stress Responses and Cortisol
  • Protein Hydrolysis and Bioactive Peptides
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Physiological and biochemical adaptations
  • Advanced Battery Materials and Technologies
  • Angiogenesis and VEGF in Cancer
  • DNA Repair Mechanisms
  • Cell death mechanisms and regulation
  • Inflammatory Biomarkers in Disease Prognosis
  • Retinoids in leukemia and cellular processes
  • Occupational exposure and asthma

Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024

Anhui Agricultural University
2024

Institute of Hydrobiology
2024

Chinese Academy of Sciences
2024

National Formosa University
2023

Affiliated Hospital of Guizhou Medical University
2021-2022

Guizhou University
2021-2022

Institute of Microbiology
2021

John Wiley & Sons (United States)
2018

Charles River Laboratories (Netherlands)
2018

To combat the coronavirus disease 2019 (COVID-19) pandemic, nonpharmaceutical interventions (NPIs) were implemented worldwide, which impacted a broad spectrum of acute respiratory infections (ARIs).Etiologically diagnostic data from 142 559 cases with ARIs, who tested for 8 viral pathogens (influenza virus [IFV], syncytial [RSV], human parainfluenza [HPIV], adenovirus [HAdV], metapneumovirus [HMPV], [HCoV], bocavirus [HBoV], and rhinovirus [HRV]) between 2012 2021, analyzed to assess changes...

10.1093/cid/ciab942 article EN Clinical Infectious Diseases 2021-11-11

The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 upregulated human colorectal cancer promotes proliferation when overexpressed a colon line. interacts with mitochondrial Ca2+ uniporter (MCU) to promote by increasing uptake energy metabolism. ubiquitination site of (RIPK1-K377) was critical this interaction MCU function promoting proliferation. These findings identify the...

10.1158/0008-5472.can-17-3082 article EN Cancer Research 2018-03-12

Primary hypertension is a chronic disease with high morbidity, and the rate of controlled blood pressure far from satisfactory, worldwide. Vaccination provides promising approach for treatment improvement in compliance. Here, ATRQβ-001 vaccine, peptide (ATR-001) derived human angiotensin II (Ang II) receptor type 1 conjugated Qβ bacteriophage virus-like particles, was developed evaluated animal models hypertension. The vaccine significantly decreased Ang II-induced hypertensive mice up to 35...

10.1161/hypertensionaha.112.201020 article EN Hypertension 2012-11-27

Atrial fibrillation (AF) is the most common clinically relevant arrhythmia. AF a strong independent risk factor for subsequent development of heart failure (HF). HF and can interact to perpetuate exacerbate each other. Soluble ST2 (sST2) biomarker cardiomyocyte stretch that useful in diagnosis prognosis HF. Its role field has not yet been well investigated. We studied concentration sST2 cohort 174 subjects (62.1% men; mean age, 65.6 ± 10.3 years [± standard deviation (SD) ]) with nonvalvular...

10.1536/ihj.16-520 article EN International Heart Journal 2017-12-26

Endothelial microparticles (EMPs) are small vesicular structures that serve as a marker of endothelial function. Angiotensin II receptor type 1 autoantibody (AT1-AA) can cause dysfunction. However, whether AT1-AA promotes EMPs formation and the mechanism remains obscure.The titres sera 126 hypertensive patients 30 normotensive individuals were evaluated by ELISA. in supernatants human umbilical vein cells (HUVECs) measured flow cytometry. The phosphorylation levels mitogen-activated protein...

10.1097/hjh.0000000000000083 article EN Journal of Hypertension 2014-03-07

Abstract Background Alumina nanoparticles (aluminaNPs), which are widely used in a range of daily and medical fields, have been shown to penetrate blood-brain barrier, distribute accumulate different brain areas. Although oral treatment aluminaNPs induces hippocampus-dependent learning memory impairments, characteristic effects exact mechanisms not fully elucidated. Here, male adult rats received single bilateral infusion (10 or 20 µg/kg body weight) into the hippocampal region, their...

10.1186/s12989-022-00477-8 article EN cc-by Particle and Fibre Toxicology 2022-05-10

Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. As the initiation factor renin-angiotensin system, renin plays critical role hypertension. In this study, we selected six peptides (rR32, rR72, rR215, hR32, hR72, hR215) belonging to potential epitopes rat human renin. The main criteria were as follows: (1) include one catalytic sites or flap sequence; (2) low/no-similarity when matched with host proteome; (3) ideal antigenicity...

10.1371/journal.pone.0066420 article EN cc-by PLoS ONE 2013-06-25

The identification problems of cultrin fish species from East Asia are discussed. Culter oxycephalus Bleeker, 1871 is found to be a senior synonym oxycephaloides Kreyenberg & Pappenheim, 1908 and redescribed. abramoides Dybowski, 1872 Erythroculter dabryi shinkainensis Yi Zhu, 1959. Examination three specimens identified as recurviceps by John Treadwell Nichols was in error. Based on the data obtained during field survey coupled with known literature latest taxonomic development relevant...

10.3897/arphapreprints.e121056 preprint EN cc-by 2024-02-19

10.1016/j.jtice.2023.105175 article EN Journal of the Taiwan Institute of Chemical Engineers 2023-10-10

Hypertension has been known to be one of the most common chronic inflammations body affecting lives many worldwide.Constant elevation blood pressure limits organ from performing at its optimal rate, and effects are more widespread throughout body.Many prescription drugs have created used by affected individuals a cost-severe financial loss and/or inescapable side effects.The race discover other alternative treatment leads newfound attention stem cell therapy where patients treated with their...

10.33425/2639-9512.1014 article EN Stem Cell & Regenerative Medicine 2017-09-30

Journal Article Upregulation of GSK-3β Activity Stimulates Protein Degradation in Skeletal Muscle Following Burn Injury Get access C. H. Fang, MD, MD 1Shriners Hospitals for Children - Cincinnati, OH; Cincinnati Medical Center, OH Search other works by this author on: Oxford Academic Google Scholar S Sheriff, PhD, PhD A Yahya, BS, BS B Li, N Kadeer, C Xiao, R. J. Kagan, FACS Care & Research, Volume 27, Issue suppl_2, March 2006, Page S70, https://doi.org/10.1097/01253092-200603001-00043...

10.1097/01253092-200603001-00043 article EN Journal of Burn Care & Research 2006-03-01
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