A5103083970- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Computational Drug Discovery Methods
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Pulmonary Hypertension Research and Treatments
- Neuropeptides and Animal Physiology
- Nuclear Receptors and Signaling
- Ubiquitin and proteasome pathways
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Liver Disease and Transplantation
- Cholesterol and Lipid Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Influenza Virus Research Studies
- Genetic Neurodegenerative Diseases
- Lung Cancer Treatments and Mutations
Huazhong University of Science and Technology
2015-2024
Union Hospital
2017-2024
Target (United States)
2024
Union Hospital
2012-2023
Ministry of Education of the People's Republic of China
2022
Wuhan Union Hospital
2019-2020
Harvard University
2001-2006
Massachusetts General Hospital
2001-2006
Scripps Research Institute
1995-2003
University of Colorado Denver
1998
Transcriptional dysregulation plays a major role in the pathology of Huntington's disease (HD). However, mechanisms causing selective downregulation genes remain unknown. Histones regulate chromatin structure and thereby control gene expression; recent studies have demonstrated therapeutic for histone deacetylase (HDAC) inhibitors polyglutamine diseases. This study demonstrates that despite no change overall acetylated levels, H3 is hypo-acetylated at promoters downregulated R6/2 mice, ST14a...
Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 7) is a novel locus associated human coronary atherosclerosis. deletion protects against atherosclerosis vascular restenosis in rodents. Methods: We designed 3 potential vaccines consisting of distinct B cell epitopic peptides derived from conjugated the carrier protein KLH (keyhole limpet hemocyanin) as well aluminum hydroxide an adjuvant. Arterial ligation or wire injury was used...
Interactions between mutant huntingtin (Htt) and a variety of transcription factors including specificity proteins (Sp) have been suggested as central mechanism in Huntington disease (HD). However, the transcriptional activity induced by Htt neurons that triggers neuronal death has yet to be fully elucidated. In current study, we characterized relationship Sp1 protein aggregation cell death. We found increased levels neuronal-like PC12 cells expressing Htt, primary striatal neurons, brain...
Abstract Vaccination provides a promising approach for treatment of hypercholesterolemia and improvement in compliance. In this study, the appropriate virus-like particle (VLP)-peptide vaccines targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) were screened. The screening criteria target peptides as follows: (1) located catalytic domain PCSK9, or regulating binding PCSK9 LDL receptors (LDLR); (2) having low/no-similarity when matched with host proteome; (3) possessing ideal...
Primary hypertension is a chronic disease with high morbidity, and the rate of controlled blood pressure far from satisfactory, worldwide. Vaccination provides promising approach for treatment improvement in compliance. Here, ATRQβ-001 vaccine, peptide (ATR-001) derived human angiotensin II (Ang II) receptor type 1 conjugated Qβ bacteriophage virus-like particles, was developed evaluated animal models hypertension. The vaccine significantly decreased Ang II-induced hypertensive mice up to 35...
Increasing evidence supports a role for cytokines as chemical signals in the CNS, either under normal conditions or pathologic state. CNS levels of cytokine interleukin-6 (IL-6) are known to be elevated several diseases associated with developmental disorders and may contribute pathological To investigate potential IL-6 such disorders, neuronal effects were examined during development using an vitro model system, cultured rat cerebellar granule neurons. The cultures prepared from 8 d...
Recently, our group has developed a therapeutic hypertensive vaccine against angiotensin (Ang) II type 1 receptor (AT1R) named ATRQβ-001. To explore its potential effectiveness on streptozotocin-induced diabetic nephropathy, male Sprague Dawley rats were randomly divided into two groups: control and model. After week, the four subgroups (each with 15 rats) for 14-week treatments saline, olmesartan, ATRQβ-001, Qβ virus-like particle (VLP), respectively. In addition to lower blood pressure,...
Background Defects in the renal fatty acid β‐oxidation pathway have been implicated development of fibrosis. Our group has developed a therapeutic vaccine targeting PCSK 9 (proprotein convertase subtilisin/kexin type 9), named 9Qβ‐003. In this study, we investigated potential effectiveness 9Qβ‐003 on hypercholesterolemia with Methods and Results The low‐density lipoprotein receptor +/− male mice fed high‐cholesterol (1%) Western diet were randomly assigned into 4 groups: sham (or control...
The Weight-adjusted Waist Index (WWI) and Cardiometabolic (CMI) are novel metrics developed to evaluate visceral fat distribution metabolic health. This study aimed explore the associations between these indices albuminuria in hypertensive patients. We conducted a cross-sectional analysis using data from National Health Nutrition Examination Survey (NHANES), obtained 2005 2020. Multivariate logistic regression models, generalized additive smooth curve fitting were employed examine...
We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on immunological effect safety VLP-based vaccine. By comparing to depolymerized dimeric ATR-Dimer-001, found that ATR-AP205-001 reached subcapsular sinus lymph node shortly after administration, followed by accumulation follicle dendritic cells...
Endothelial microparticles (EMPs) are small vesicular structures that serve as a marker of endothelial function. Angiotensin II receptor type 1 autoantibody (AT1-AA) can cause dysfunction. However, whether AT1-AA promotes EMPs formation and the mechanism remains obscure.The titres sera 126 hypertensive patients 30 normotensive individuals were evaluated by ELISA. in supernatants human umbilical vein cells (HUVECs) measured flow cytometry. The phosphorylation levels mitogen-activated protein...
Objective: Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. Previously, we invented ATRQβ-001 vaccine which showed a desirable blocking effect for AT1R. The purpose of this study was investigate whether would prevent atherosclerosis in apolipoprotein E-null (ApoE–/–) mice. Methods: Male ApoE–/– mice were administered with vaccine, Qβ virus-like particles, valsartan or vehicle over period 24 weeks. In vitro, human coronary artery endothelial...
The α1-AR (α1 adrenergic receptor) blockers currently on the market cannot meet clinical needs because of low-selectivity for subtypes α1-ARs, short half-life, and uncertain role in cardiovascular end point events. study sought to find a vaccine specifically against α1D-AR (α1D-adrenergic treating hypertension. A peptide ADR-004 (cgiteeagy) belonging was screened, ADRQβ-004 produced injected into spontaneously hypertensive rats model (including short-term study, 10 weeks, long-term...
Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. As the initiation factor renin-angiotensin system, renin plays critical role hypertension. In this study, we selected six peptides (rR32, rR72, rR215, hR32, hR72, hR215) belonging to potential epitopes rat human renin. The main criteria were as follows: (1) include one catalytic sites or flap sequence; (2) low/no-similarity when matched with host proteome; (3) ideal antigenicity...
The excessive and ectopic pulmonary artery smooth muscle cells (PASMCs) are crucial to the pathogenesis of arteriole (PA) remodeling in arterial hypertension (PAH). We previously found that microRNA (miR)-30a was significantly increased acute myocardial infarction (AMI) patients animals, as well cultured cardiomyocytes after hypoxia, suggesting it might be strongly associated with hypoxia-related diseases. Here, we investigated role miR-30a PASMC PAH. expression higher serum PAH compared...
Background and Purpose Hypertension has been the leading preventable cause of premature death worldwide. The aim this study was to design a more efficient vaccine against novel targets for treatment hypertension. Experimental Approach epitope CE12, derived from human L‐type calcium channel (Ca V 1.2), designed conjugated with Qβ bacteriophage virus‐like particles test efficacy in hypertensive animals. Further, hepatitis B core antigen (HBcAg)‐CE12‐CQ10 vaccine, bivalent based on HBcAg...