A5036626585- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Cardiac Fibrosis and Remodeling
- Pulmonary Hypertension Research and Treatments
- Orthopaedic implants and arthroplasty
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Lipoproteins and Cardiovascular Health
- SARS-CoV-2 and COVID-19 Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Neuropeptides and Animal Physiology
- Immune cells in cancer
- Vestibular and auditory disorders
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- GDF15 and Related Biomarkers
- Trace Elements in Health
- Adipokines, Inflammation, and Metabolic Diseases
Huazhong University of Science and Technology
2015-2025
Loudi Central Hospital
2023-2025
Union Hospital
2015-2025
Target (United States)
2024
Union Hospital
2012-2023
Wuhan Union Hospital
2019-2023
Weatherford College
2021
Affiliated Hospital of Nantong University
2020
Nantong University
2020
Lishui City People's Hospital
2013
In this study, we aimed to clinically and genetically characterize LVNC patients investigate the prevalence of variants in known novel disease genes.Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause heart failure, arrhythmia, thromboembolism, sudden cardiac death. We sought here dissect its genetic causes, phenotypic presentation outcome.In our registry with follow-up median 61 months, analysed 95 (68 unrelated index 27 affected relatives; definite...
Abstract Background This study explores the intricate relationship between smoking, cardiovascular disease (CVD) risk factors and their combined impact on overall CVD risk, utilizing data from NHANES 2011–2018. Methods Participants were categorized based presence of CVD, we compared demographic, social, clinical characteristics. We utilized logistic regression models, receiver operating characteristics (ROC) analysis, chi-squared test to examine associations variables risk. Results...
In this study, we investigated the hypothesis that regulatory T cells (T(reg)) are involved in immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted 55 RA patients and 42 control subjects allocated to either a group treated with atorvastatin (AT) (20 mg/day) or non-AT group. T(reg) numbers, suppressive function, serum inflammatory markers, disease activity were evaluated before after therapy. Furthermore, AT frequency function...
Abstract Vaccination provides a promising approach for treatment of hypercholesterolemia and improvement in compliance. In this study, the appropriate virus-like particle (VLP)-peptide vaccines targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) were screened. The screening criteria target peptides as follows: (1) located catalytic domain PCSK9, or regulating binding PCSK9 LDL receptors (LDLR); (2) having low/no-similarity when matched with host proteome; (3) possessing ideal...
Aims: Increasing evidences confirm the role of immune activation in pathogenesis chronic heart failure (CHF). Regulatory T cells appear central to control homeostasis. We assessed hypothesis that circulating frequency and function CD4+CD25+ Foxp3+CD127low regulatory (Tregs) would be deranged patients with CHF. Methods: Ninety-nine CHF due non-ischemic (NIHF) or ischemic etiology (IHF) 24 donors were enrolled study. Frequency Tregs was evaluated by flow cytometry. Foxp3 peripheral blood...
Primary hypertension is a chronic disease with high morbidity, and the rate of controlled blood pressure far from satisfactory, worldwide. Vaccination provides promising approach for treatment improvement in compliance. Here, ATRQβ-001 vaccine, peptide (ATR-001) derived human angiotensin II (Ang II) receptor type 1 conjugated Qβ bacteriophage virus-like particles, was developed evaluated animal models hypertension. The vaccine significantly decreased Ang II-induced hypertensive mice up to 35...
Abstract As a main element in the hard metal industry, cobalt is one of major components human implants. Cobalt-containing implants, especially joint prostheses used for artificial replacement, can be corroded due to complex physiological environment vivo, producing large number nanoscale particles (Cobalt Nanoparticles, CoNPs). These CoNPs first accumulated around implant cause adverse local reactions and then enter into blood vessels followed by reaching liver, heart, brain, kidney, other...
Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, characteristics cells EAT HF patients have rarely been elucidated.To identify key EAT, integrated bioinformatics analysis was performed on public datasets. samples with paired subcutaneous (SAT), heart, peripheral blood from were collected validation experiments. T cell receptor (TCR) repertoire assessed by high-throughput sequencing. The phenotypic...
Recently, our group has developed a therapeutic hypertensive vaccine against angiotensin (Ang) II type 1 receptor (AT1R) named ATRQβ-001. To explore its potential effectiveness on streptozotocin-induced diabetic nephropathy, male Sprague Dawley rats were randomly divided into two groups: control and model. After week, the four subgroups (each with 15 rats) for 14-week treatments saline, olmesartan, ATRQβ-001, Qβ virus-like particle (VLP), respectively. In addition to lower blood pressure,...
Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity mortality independently of conventional cardiovascular disease (CVD) factors. This study was designed to identify feasible indicators predicting arterial stiffness progression.We followed up 816 normotensive participants without diabetes or CVD nearly 5.0 years. Cholesterol parameters, other clinical laboratory data were collected...
Background Defects in the renal fatty acid β‐oxidation pathway have been implicated development of fibrosis. Our group has developed a therapeutic vaccine targeting PCSK 9 (proprotein convertase subtilisin/kexin type 9), named 9Qβ‐003. In this study, we investigated potential effectiveness 9Qβ‐003 on hypercholesterolemia with Methods and Results The low‐density lipoprotein receptor +/− male mice fed high‐cholesterol (1%) Western diet were randomly assigned into 4 groups: sham (or control...
Objective: This study aims to investigate the differences in emotional status and cognitive function among patients with vestibular migraine (VM), Meniere's disease (MD), their comorbidity (VMMD), analyze key factors influencing function. Methods: cross-sectional included 96 outpatients (32 males, 64 females, aged 21-73 years) from Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University Science Technology, between December 2022 2023. The population...
This review examines the neurobiological mechanisms by which plant-derived compounds influence women's reproductive health through neuroendocrine-reproductive axis. Gynecological disorders frequently present with neurological manifestations, including cognitive decline in perimenopause, anxiety and depression polycystic ovary syndrome (PCOS), central sensitization endometriosis. Bioactive from medicinal plants, polyphenols phytoestrogens, demonstrate therapeutic potential their...
Our study intended to prove whether agonistic autoantibodies angiotensin II type 1 receptor (AT1-AAs) exist in patients with coronary heart disease (CHD) and affect the human endothelial cell (HEC) by upregulating proinflammatory cytokines expression involved NF-κB pathway. Antibodies were determined chronotropic responses of cultured neonatal rat cardiomyocytes coupled receptor-specific antagonists (valsartan AT1-EC2) as described previously. Interleukin-6 (IL-6), vascular adhesion...
We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on immunological effect safety VLP-based vaccine. By comparing to depolymerized dimeric ATR-Dimer-001, found that ATR-AP205-001 reached subcapsular sinus lymph node shortly after administration, followed by accumulation follicle dendritic cells...