A5100403003- Effects and risks of endocrine disrupting chemicals
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Water Treatment and Disinfection
- Cyclopropane Reaction Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Synthesis and properties of polymers
- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Ovarian function and disorders
- RNA modifications and cancer
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Reproductive Biology and Fertility
- Catalytic C–H Functionalization Methods
- Toxic Organic Pollutants Impact
- Chronic Lymphocytic Leukemia Research
- Amyotrophic Lateral Sclerosis Research
- Assisted Reproductive Technology and Twin Pregnancy
- Neurogenetic and Muscular Disorders Research
- Myasthenia Gravis and Thymoma
- Reproductive Health and Technologies
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Ruijin Hospital
2012-2025
Shanghai Jiao Tong University
2021-2025
Shanxi Academy of Medical Sciences
2024-2025
Shanxi Medical University
2024-2025
Jilin University
2025
Ministry of Ecology and Environment
2020-2024
Shanghai East Hospital
2024
Union Hospital
2007-2024
Abstract Chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder (NMOSD). To evaluate the safety efficacy of CT103A, a self-developed BCMA-targeting CAR construct against BCMA, patients with AQP4-IgG seropositive NMOSD, an ongoing, investigator-initiated, open-label, single-arm, phase 1 clinical trial is conducted at our...
Immune-mediated necrotizing myopathy (IMNM) is an autoimmune disorder associated with the presence of autoantibodies, characterized by severe clinical presentation rapidly progressive muscular weakness and elevated levels creatine kinase, while traditional pharmacological approaches possess varying often limited effects. Considering pathogenic role chimeric antigen receptor (CAR)-T cells targeting B cell maturation (BCMA) have emerged as a promising therapeutic strategy. We reported here...
B-cell maturation antigen (BCMA), expressed in plasmablasts and plasma cells, could serve as a promising therapeutic target for autoimmune diseases. We reported here chimeric receptor (CAR) T cells targeting BCMA two patients with highly relapsed refractory myasthenia gravis (one AChR-IgG, one MuSk-IgG). Both exhibited favorable safety profiles persistent clinical improvements over 18 months. Reconstitution of lineages sustained reduced pathogenic autoantibodies might underlie the efficacy....
Background and Purpose— Ischemic postconditioning (Postcond) is defined as a series of intermittent interruptions blood flow in the early phase reperfusion that mechanically alters hydrodynamics reperfusion. A recent study showed Postcond reduced infarct size cerebral ischemia/reperfusion (I/R) injury. However, little known about mechanisms I/R In present study, we investigated effects focal injury rat middle artery occlusion model. Methods— Adult male Sprague-Dawley rats were treated with...
A critical bottleneck for the credibility of artificial intelligence (AI) is replicating results in diversity clinical practice. We aimed to develop an AI that can be independently applied recover high-quality imaging from low-dose scans on different scanners and tracers.
Chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of neurological autoimmune diseases is promising, but CAR kinetics and immune alterations after are poorly understood. Here, we performed single-cell multi-omics sequencing paired cerebrospinal fluid (CSF) blood samples from patients with neuromyelitis optica spectrum disorder (NMOSD) treated anti-B maturation (BCMA) cells. Proliferating cytotoxic-like CD8
To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized evaluated in a 9L glioma rat model. Fluorescence studies demonstrate that Pyro-2DG is selectively accumulated the tumor. Upon its photoactivation, we this agent efficiently causes selective mitochondrial damage to region of tumor photoirradiated after administration agent, but does not affect tissues absence or treated...
AbstractAbstract Amphiregulin was expressed in alveolar macrophages after acute lung injury. Exogenous amphiregulin protected, whereas antibodies exacerbated The results are consistent with the notion up-regulation of activated can exert a protective effect on tissue model Supplemental Digital Content is available text. Background Alveolar (AMs) into M1 phenotype involved development lipopolysaccharide-induced injury (ALI). However, whether AMs express and what roles plays ALI remain poorly...
Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes brain by increasing extracellular bulk flow. Herein, we propose that chronic insufficiency young adult wild-type mice is also linked with dysfunction intracellular protein degradation pathways microglia-mediated neuroinflammation, which are potentially important mechanisms the initiation neurodegeneration.We...
Human studies on association between bisphenol A (BPA) exposure and semen quality, mostly based single urinary measurement, are inconsistent. There is limited human evidence BPA analogues such as F (BPF) S (BPS), little known potential effects of mixtures. We aimed to explore whether individual or mixtures BPA, BPS BPF assessed in repeated measurements were associated with quality among 984 Chinese men from an infertility clinic. found that higher was increased odds ratios (ORs) having...
Abstract Niemann‐Pick type C (NPC) disease is an autosomal recessive, lethal neurodegenerative disorder. Although neurodegeneration of Purkinje cells in the mouse model ( Npc1 –/– ) thought to be autonomous, basis neuronal death other regions brain remains elusive. We addressed this issue vivo by using glial fibrillary acidic protein (GFAP) promoter direct astrocyte‐specific, replacement expression mice. These mice showed enhanced survival, decreased storage cholesterol associated with less...
Ischemic post-conditioning (Post-cond) is a phenomenon in which intermittent interruptions of blood flow the early phase reperfusion can protect organ from ischemia/reperfusion (I/R) injury. Recent studies demonstrated ischemic Post-cond reduced infarct size cerebral I/R However, molecular mechanisms underlying this are not completely understood. As inflammation known to be detrimental neurological outcome during acute after stroke, we investigated whether played its protective role...
Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as atherosclerosis post-infarction myocardial inflammation. However, whether how SCFAs inflamed aortas subjects with abdominal aortic aneurysm (AAA) remains unclear. Here, authors revealed protective effect on AAA mice expansion Tregs cLP, propionate exerted...
Radiofrequency catheter ablation (RFCA) is now an established therapeutic option for patients with atrial fibrillation (AF), but the long-term recurrence rate of AF still high. Sacubitril/valsartan (Sac/Val) superior to valsartan in attenuating ventricular remodelling and improving clinical outcomes heart failure patients, whether this additional benefit exists reversing reducing RFCA-treated remains uncovered.Patients that had undergone RFCA were enrolled randomly assigned 1:1 (160 mg/day)...
Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response pathological stimuli. This process results the loss of typical astrocyte functions acquisition neurotoxic or neuroprotective roles. A growing body research indicates that these astrocytes play a pivotal role pathogenesis amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid lactate...
Background: Experimental studies have shown that disinfection byproducts (DBPs) including haloacetic acids (HAAs) can cause liver toxicity, but evidence linking this association in humans is sparse. Objectives: We aimed to explore the associations between HAA exposures and injury. Methods: included 922 women December 2018 January 2020 from Tongji Reproductive Environmental (TREE) cohort study Wuhan, China. Urinary concentrations trichloroacetic acid (TCAA) dichloroacetic (DCAA) serum...