A5080879011- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- Regulation of Appetite and Obesity
- Pediatric health and respiratory diseases
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Diet and metabolism studies
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Child Nutrition and Feeding Issues
- Heme Oxygenase-1 and Carbon Monoxide
- Estrogen and related hormone effects
- Food Security and Health in Diverse Populations
- Sleep and related disorders
- Biochemical Analysis and Sensing Techniques
- Iron Metabolism and Disorders
- Smoking Behavior and Cessation
- Prenatal Substance Exposure Effects
- Pregnancy and Medication Impact
Huazhong University of Science and Technology
2016-2025
Tampere University Hospital
2024
Tampere University
2024
Harvard University
2009-2024
Sheffield Hallam University
2024
Insper
2024
Wuhan Children's Hospital
2022
China Academy of Safety Sciences and Technology
2020
PLA 306 Hospital
2014
University of North Carolina at Chapel Hill
1997
A growing number of epidemiologic studies have estimated associations between type 2 diabetes mellitus and exposure to metals. However, on the internal assessments metal gestational (GDM) are limited in scope inconsistent outcomes.This investigation aimed explore urinary nickel (Ni), arsenic (As), cadmium (Cd), antimony (Sb), cobalt (Co), or vanadium (V) early pregnancy subsequent risk GDM Chinese pregnant women.The study population included 2090 women with singleton from Tongji Maternal...
Food frequency questionnaire (FFQ) is a reliable tool to estimate dietary intake in large nutritional epidemiological studies, but there lack of current and validated FFQ for use urban Chinese pregnant women. This study aimed evaluate the reproducibility validity semi-quantitative designed among women cohort conducted central China. In study, sample 123 healthy completed first at 12–13 weeks gestation second 3–4 later. To validate FFQ, three 24-h recalls (24HRs) between intervals two FFQs....
Background Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 and type 2 diabetes mellitus (T2DM). Methods Findings 581 cases with newly-diagnosed T2DM (New-T2DM) 611 comparison controls were recruited this two-phase case-control study, comprising 420 429 collected first phase 161 182 second replication study. Analyses, using both separated...
Inflammation has been implicated in the hypothalamic leptin and insulin resistance resulting defective food intake during high fat diet period. To investigate inflammation dietary induced obesity (DIO) resistant (DIO-R) rats, we established rat models of DIO DIO-R by feeding for 10 weeks. Then switched half rats to chow other following 8 weeks explore response low intervention. Body weight, caloric intake, HOMA-IR, as well mRNA expression TLR4, NF-κB, TNF-α, IL-1β, IL-6 DIO/HF were...
Abstract Maternal dietary patterns and macronutrients intake have been shown to affect the development of gestational diabetes mellitus (GDM), but findings are inconsistent. We aimed identify maternal examine their associations with GDM risk, evaluate contributions these associations. included 2755 Chinese pregnant women from Tongji Child Health Cohort. Dietary intakes were assessed using a validated semi-quantitative FFQ 2 weeks before diagnosis GDM. ( n 248) was diagnosed based on results...
We previously demonstrated that the estrogen response module (mERM) of mouse lactoferrin gene, which contains an overlapping chicken ovalbumin upstream promoter transcription factor (COUP-TF)- and receptor-binding element, is responsible for induction. In this report we show COUP-TF represses mERM to stimulation. Mutation deletion COUP-TF-binding element or reduction endogenous increases responsiveness. Likewise, overexpression expression vector blocked estrogen-stimulated in transfected...
The association between iron supplementation and gestational diabetes mellitus (GDM) is still inconclusive, this has not been extensively studied in relation to plasma ferritin the early second trimester. We aimed prospectively examine independent combined associations of concentrations supplement use with GDM. 2117 women from Tongji Maternal Child Health Cohort Wuhan, China. Plasma around 16 weeks' gestation was measured by ELISA kits information on collected questionnaires. GDM diagnosed a...
Constipation is a very common health problem in the world. Intake of sufficient amount dietary fibers cornerstone prevention and treatment constipation. As traditional medicine, flaxseed has been used to treat constipation for centuries, but controlled trials are rare. The purpose present study was assess that whether partially defatted meal (PDFM) potential role facilitate fecal output normal experimental constipated mice.After supplemented with 2.5%, 5% 10% (w/w) PDFM (L-, M- H-PDFM) 14...
The relation between infant feeding and growth has been extensively evaluated, but studies examining the volume of formula milk consumption on are limited. This study aimed to examine effects early larger volumes risk overweight in later infancy. In total, 1093 infants were studied prospectively. Milk records collected at 3 mo age used define following groups: breast (BM, no formula), lower-volume (LFM, <840 ml formula/d), higher-volume (HFM, ≥840 formula/d). Body weight length measured time...
Current results regarding the effect of folic acid (FA) supplement use on gestational hypertension (GH) and preeclampsia are limited inconsistent. We aimed to investigate whether FA was associated with GH preeclampsia. Participants from Tongji Maternal Child Health Cohort information periconceptional diagnosis GH/preeclampsia were included (n=4853). Robust Poisson regression used assess association Among 4853 participants in this study, 1161 (23.9%) 161 (3.3%) women diagnosed preeclampsia,...
Abstract Background The evidence on the relationship between diet diversity in early life and allergic outcomes was few inconsistent. We sought to determine association of food first year with second year. Methods Two thousand two hundred fifty‐one mother‐infant pairs from Tongji Maternal Child Health Cohort (TMCHC) were involved study. Information complementary foods introduction obtained by telephone interview at 6‐ 12‐month postpartum follow‐up. Any doctor‐diagnosed diseases recorded...
The 5'-flanking region of the human lactoferrin gene was isolated from a placental genomic library. This clone contains 16-kilobase pair (kbp) insert and produces seven fragments when digested with SacI restriction enzyme. We sequenced one that comprises 1294 bp sequence, 79 first exon, 690 intron. A major transcription start site mapped by primer extension. immediately upstream initiation following exon is abundant in G C nucleotides. In promoter within 300-bp stretch (-465 to -165) DNA, we...
Estrogen receptor-related orphan receptor alpha 1 is a member of the steroid/thyroid nuclear superfamily. We have previously cloned human estrogen (hERR 1) cDNA and demonstrated that it enhances responsiveness lactoferrin gene promoter in transfected endometrial carcinoma cells. In present study, we used hERR as probe isolated mouse homologue ERR from libraries brain kidney. Sequence comparison between (mERR revealed homologies are 89% nucleotides 97% amino acids. By electrophoresis mobility...
Scopes To investigate the effects of high-fat diet enriched with lard oil or soybean on liver endoplasmic reticulum (ER) stress and inflammation markers in diet-induced obese (DIO) rats estimate influence following low-fat feeding. Methods Results Male SD were fed standard (LF, n = 10) two isoenergentic diets (HL, 45) (HS, respectively for 10 weeks. Then DIO from HL HS either continuously (HL/HL, HS/HS) switched to (HL/LF, HS/LF) another 8 Rats control group maintained diet. Body fat, serum...