A5034567911- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Reproductive tract infections research
- Gynecological conditions and treatments
- Reproductive Health and Technologies
- Uterine Myomas and Treatments
- TGF-β signaling in diseases
- Ovarian cancer diagnosis and treatment
- Sperm and Testicular Function
- Estrogen and related hormone effects
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Adolescent Sexual and Reproductive Health
- Genital Health and Disease
- Global Public Health Policies and Epidemiology
- Per- and polyfluoroalkyl substances research
- Optical Imaging and Spectroscopy Techniques
- Endometrial and Cervical Cancer Treatments
- Effects and risks of endocrine disrupting chemicals
- Growth Hormone and Insulin-like Growth Factors
- Peripheral Artery Disease Management
Carolina Veterinary Specialists
2023
Family Healthcare
2013-2019
Duke University
2005-2018
Duke University Hospital
1989-2018
Duke Medical Center
2003-2018
Duke Institute for Health Innovation
2011-2018
University of North Carolina at Chapel Hill
1997-2015
National Institute of Environmental Health Sciences
1991-2006
National Institutes of Health
1991-2006
Wolters Kluwer Health
2005
The in vivo studies presented here demonstrate that epidermal growth factor (EGF) is an important autocrine and/or paracrine mediator of estrogen-induced and differentiation mouse uterus vagina. An antibody specific for EGF significantly inhibited uterine vaginal growth, thereby implicating involvement estrogen action. Furthermore, administered via slow-release pellets ovariectomized mice acted as a potent mitogen well inducer keratinization. Experiments with ovariectomized,...
We propose, and offer evidence to support, the concept that many uterine leiomyomas pursue a self-limited life cycle. This cycle can be arbitrarily divided on basis of morphologic assessment collagen content into 4 phases: (1) proliferation, (2) proliferation synthesis collagen, (3) early senescence, (4) involution. Involution occurs as result both vascular interstitial ischemia. Interstitial ischemia is consequence excessive elaboration resulting in reduced microvascular density, increased...
Lactoferrin (LTF), an iron-binding glycoprotein present in most exocrine secretions and the secondary granules of polymorphonuclear leucocytes (PMN), is regulated by estrogen mouse reproductive tract. We investigated expression LTF mRNA protein during natural estrous cycle to increase our understanding how this uterine secretory under physiological conditions. There was a positive correlation between genital tract serum estradiol (E2) concentrations. When E2 peaked proestrus, were expressed...
The 5'-flanking region of the human lactoferrin gene was isolated from a placental genomic library. This clone contains 16-kilobase pair (kbp) insert and produces seven fragments when digested with SacI restriction enzyme. We sequenced one that comprises 1294 bp sequence, 79 first exon, 690 intron. A major transcription start site mapped by primer extension. immediately upstream initiation following exon is abundant in G C nucleotides. In promoter within 300-bp stretch (-465 to -165) DNA, we...
Abstract Background Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated interactions between human uterine leiomyoma (UtLM) cells and leiomyoma-derived fibroblasts (FB), their importance in cell growth ECM protein production using a coculture system. Results We found enhanced proliferation, elevated levels of collagen type I insulin-like factor-binding protein-3 after coculturing....
Objectives: In vitro fertilization (IVF) has the potential to give babies millions more people globally, yet it continues be underutilized. We established a globally applicable and locally adaptable IVF prognostics report framework support patient–provider counseling enable validated, data-driven treatment decisions. This study investigates utilization rates associated with usage of machine learning, center-specific (MLCS) prognostic reports (the Univfy® report) in provider-patient...
In Brief Background Human papillomavirus (HPV) testing as primary cervical cancer screening has not been studied in Caribbean women. We tested vaginal self-collection versus physician sampling a population of Haitian Methods Participants were screened for high-risk HPV with self-performed and clinician-collected samples using Hybrid Capture 2 assays (Qiagen, Gaithersburg, MD). Women positive by either method then underwent colposcopy biopsy all visible lesions. Sensitivity predictive value...
This 2009 qualitative study investigated Haitian women's most pressing health needs, barriers to meeting those needs and proposed solutions, how they thought the community outside organizations should be involved in addressing their needs. The impetus for was get input into development of a Family Health Centre Leogane, Haiti. Individual interviews focus group discussions were conducted with 52 adult women six communities surrounding Leogane. named by accessible, available affordable care,...
Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies validate use of this technology settings require power consumption good quality control that is minimally influenced by operator or variable environmental conditions field. The goal study was evaluate effects two sources error: calibration pressure on extraction absorption scattering properties...
Cervical cancer is the second most common in women worldwide and leading cause of deaths Tanzanian women. Prevention cervical relies on detection treatment Squamous Intraepithelial Lesion (SIL), a premalignant disease stage. Worldwide there are overwhelming reports associating SIL HIV infection, however Tanzania such limited. A cross-sectional hospital-based descriptive study was conducted to determine prevalence severity 234 seropositive seronegative aged 18-68 years old at Kilimanjaro...
The reconstruction of healthcare systems in developing countries after natural disasters is poorly understood. Using data collected before and the 2010 Haiti earthquake, we detail response aid agencies their interaction with local providers Leogane, city closest to epicenter. We find that period earthquake was associated an increase total number facilities, inpatient beds, surgical facilities international has been a driving force behind this recovery. Aid funded 12 13 new have opened since...
Human granulosa-luteal cells and cumulus obtained from women undergoing in vitro fertilization embryo transfer (IVF-ET) were examined for the presence of TGF-beta 1 2 mRNA by reverse transcription-polymerase chain reaction (RT-PCR) analysis. RT-PCR analysis revealed that both follicle cell types express subtypes. Verification products was done restriction enzyme digestion These results suggest a role(s) development human oocyte-cumulus complex.