A5100687158- Glioma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Meningioma and schwannoma management
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Pancreatitis Pathology and Treatment
- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Synthesis and biological activity
- Sirtuins and Resveratrol in Medicine
- Cytokine Signaling Pathways and Interactions
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Quinazolinone synthesis and applications
- 3D Printing in Biomedical Research
Hammersmith Hospital
2023
Imperial College London
2023
University of Arizona
1995-2022
Beijing Tsinghua Chang Gung Hospital
2017-2022
Tsinghua University
2017-2022
VA West Los Angeles Medical Center
2022
University of British Columbia
2021
Institute for Myeloma & Bone Cancer Research
2006-2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2013-2020
University of California, San Diego
2018-2019
The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective and MAP-ERK (MEK) inhibitors have shown clinical efficacy patients with melanoma. However, majority responses are transient, resistance is often associated pathway reactivation extracellular signal-regulated (ERK) signaling Here, we describe identification characterization SCH772984, a novel selective inhibitor ERK1/2 that...
Abstract Numerous biomolecular markers have been studied to improve the accuracy of fine needle aspiration biopsy (FNAB) in diagnostic and prognostic evaluation thyroid tumors, but none them has yet become clinically useful. The recently discovered BRAF mutation, which occurs specifically papillary cancers (PTC) with a high prevalence is associated poor clinicopathological outcomes, potential be useful marker for PTC. In present study, we investigated whether detection mutation on FNAB...
Globally, there are an estimated 10.6 million cases of meningitis and 288,000 deaths every year, with the vast majority occurring in low- middle-income countries. In addition, many survivors suffer from long-term neurological sequelae. Most laboratories assay only for common bacterial etiologies using culture directed PCR, lack microbiological diagnoses, impeding institution evidence-based treatment prevention strategies. We report here results a validation application study unbiased...
Diseases of gut inflammation such as neonatal necrotizing enterocolitis (NEC) result after an injury to the mucosal lining intestine, leading translocation bacteria and endotoxin (lipopolysaccharide). Intestinal defects are repaired by process intestinal restitution, during which enterocytes migrate from healthy areas sites injury. In animal model NEC, we determined that restitution was significantly impaired compared with control animals. We therefore sought determine mechanisms governing...
Vascular endothelial cells maintain the interface between systemic circulation and soft tissues mediate critical processes such as inflammation in a vascular bed-selective fashion. To expand our understanding of genetic pathways that underlie these specific functions, we have focused on identification novel genes are differentially expressed all cells, well restricted groups this cell type. Virtual subtraction was conducted employing gene expression data deposited public databases 384...
ABSTRACT Background and Purpose . To assess the magnetic resonance (MR) imaging characteristics of spinal intramedullary ependymomas. Methods MR images were obtained from 60 patients with All treated surgically, pathological diagnoses con‐firmed. ependymomas associated cysts correlated surgical findings. Results Among cases ependymomas, 39 cervical 11 thoracic, 10 located at conus medullaris filum terminale. The lesions measured 1 to vertebral segments in length along neuraxis, a mean 3.7...
We have previously shown that appropriate modification of the benzocycloheptapyridine tricyclic ring system can provide potent farnesyl protein transferase (FPT) inhibitors with good cellular activity. Our laboratories also established incorporation either pyridinylacetyl N-oxide or 4-N-carboxamidopiperidinylacetyl moieties results in pharmacokinetically stable are orally efficacious nude mice. now demonstrate further elaboration by introducing a bromine atom at 7- 10-position...
Diseases of intestinal inflammation like necrotizing enterocolitis (NEC) are associated with impaired epithelial barrier integrity and the sustained release nitric oxide (NO). NO modifies cytoskeletal regulator RhoA-GTPase, suggesting that could affect healing by inhibiting restitution. We now hypothesize inhibits enterocyte migration through RhoA-GTPase sought to determine pathways involved. The induction NEC was increased bromodeoxyuridine-labeled enterocytes from terminal ileal crypts...
The emergence and evolution of new immunological cancer therapies has sparked a rapidly growing interest in discovering novel pathways to treat cancer. Toward this aim, series pyrrolidine derivatives (compound 5) were identified as potent inhibitors ERK1/2 with excellent kinase selectivity dual mechanism action but suffered from poor pharmacokinetics (PK). challenge PK was overcome by the discovery 3(S)-thiomethyl analog 7. Lead optimization through focused structure–activity relationship...
Bruton's tyrosine kinase (BTK) is a Tec family with well-defined role in the B cell receptor (BCR) pathway. It has become an attractive target for selective inhibition and treatment of related diseases. We report series compounds based on 8-amino-imidazo[1,5-a]pyrazine that are potent reversible BTK inhibitors excellent selectivity. Selectivity achieved through specific interactions ligand hinge driven by aminopyridine hydrogen bondings Ser538 Asp539, hydrophobic interaction...
Current practice guidelines for managing patients with chronic myelogenous leukemia (CML) call monitoring BCR-ABL transcript concentrations a quantitative reverse transcription-PCR (qRT-PCR) assay. Because the available laboratory-developed assays lack consensus on appropriate design, reporting of results, and reference intervals, we developed evaluated an integrated assay that yields standardized results any laboratory can be performed by technicians no specialized training.We used Cepheid...
Objective: The aim of this study was to assess changes in symptomatology attentiondeficit/ hyperactivity disorder (ADHD) with extended-release dexmethylphenidate (d-MPHER) versus placebo a laboratory classroom setting. Methods: This double-blind, placebo-controlled, crossover randomized 54 children 6–12 years age, stabilized on methylphenidate 20–40 mg/day. Patients participated practice day, then received 5 days treatment d-MPH-ER 20 mg/day or placebo. After 1-day wash-out, they returned...
Abstract Recent studies implicating the Rho family of small G proteins in regulation neuronal morphology have focused attention on identifying key components signaling pathways neurons. To this end, we conducted aimed at defining localization and function Tech, a guanine nucleotide exchange factor (GEF) member that is highly enriched brain. We found Tech selectively expressed cortical hippocampal neurons with prominent immunostaining apparent cell bodies dendrites these cells. In vitro...
Abstract Purpose MRI and PET are used in neuro-oncology for the detection characterisation of lesions malignancy to target surgical biopsy plan resections or stereotactic radiosurgery. The critical role short-chain fatty acids (SCFAs) brain tumour biology has come forefront. non-metabolised SCFA radiotracer, [ 18 F]fluoropivalate (FPIA), shows low background signal most tissues except eliminating organs appropriate human dosimetry. Tumour uptake radiotracer is, however, unknown. We...
Stimulation of Toll-like receptors (TLRs) and/or NOD-like on immune cells initiates and directs responses that are essential for vaccine adjuvants. The small-molecule TLR7 agonist, imiquimod, has been approved by the FDA as an response modifier but is limited to topical application due its poor pharmacokinetics causes undesired adverse effects. Nanoparticles increasingly used with innate stimulators mitigate side effects enhance adjuvant efficacy. In this study, a potent...
Small stem cells, such as spore-like blastomere-like cells (BLSCs), and very-small embryonic-like (VSELs) have been described in recent studies, although their multipotency human tissues has not yet confirmed. Here, we report the discovery of adult multipotent derived from bone marrow, which call StemBios (SB) cells. These isolated SB are smaller than 6 ìm DAPI+ Lgr5+ (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5). Because Lgr5 characterized a cell marker intestine,...