A5026441051- Synthesis and biological activity
- Melanoma and MAPK Pathways
- Neonatal Respiratory Health Research
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Asymmetric Synthesis and Catalysis
- Emergency and Acute Care Studies
- Synthetic Organic Chemistry Methods
- Computational Drug Discovery Methods
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Protein Kinase Regulation and GTPase Signaling
- Biochemical and Molecular Research
- Congenital Heart Disease Studies
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Synthesis of heterocyclic compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Infant Nutrition and Health
- Lysosomal Storage Disorders Research
- Cardiovascular Conditions and Treatments
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
University of Mississippi Medical Center
2017-2023
Mississippi State Department of Health
2023
Jackson Memorial Hospital
2018-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2013-2018
University of Mississippi
2018
Children's Hospital of Michigan
2017
Wayne State University
2017
Hutzel Women's Hospital
2017
Merck (France)
2016
Duke University
1998
The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective and MAP-ERK (MEK) inhibitors have shown clinical efficacy patients with melanoma. However, majority responses are transient, resistance is often associated pathway reactivation extracellular signal-regulated (ERK) signaling Here, we describe identification characterization SCH772984, a novel selective inhibitor ERK1/2 that...
Abstract Background The available data regarding morbidity and mortality associated with multiple gestation births is conflicting contradicting. Objective To compare morbidity, mortality, length of stay (LOS) outcomes between (twin, triplet higher-order) singleton births. Methods Data from the national multicenter Kids’ Inpatient Database Healthcare Cost Utilization Project years 2000, 2003, 2006, 2009, 2012, 2016 were analyzed using a complex survey design Statistical Analysis System (SAS)...
We have previously shown that appropriate modification of the benzocycloheptapyridine tricyclic ring system can provide potent farnesyl protein transferase (FPT) inhibitors with good cellular activity. Our laboratories also established incorporation either pyridinylacetyl N-oxide or 4-N-carboxamidopiperidinylacetyl moieties results in pharmacokinetically stable are orally efficacious nude mice. now demonstrate further elaboration by introducing a bromine atom at 7- 10-position...
The emergence and evolution of new immunological cancer therapies has sparked a rapidly growing interest in discovering novel pathways to treat cancer. Toward this aim, series pyrrolidine derivatives (compound 5) were identified as potent inhibitors ERK1/2 with excellent kinase selectivity dual mechanism action but suffered from poor pharmacokinetics (PK). challenge PK was overcome by the discovery 3(S)-thiomethyl analog 7. Lead optimization through focused structure–activity relationship...
Abstract Cardo polysulfonates (PSBCB and PSBCT) of 1,1′-bis(4-hydroxy phenyl)cyclohexane with benzene-1,3 toluene-2,4-disulfonyl chlorides have been synthesized by interfacial polycondensation (0.005 mol) benzene-1,3/toluene-2,4-disulfonyl using water-chloroform (4:1, v/v) as interphase, alkali (0.015 acid acceptor, cetyl trimethyl ammonium bromide (0.125 g) emulsifier at 0°C for 3 hours. The structures the polymers were supported IR NMR spectral data. PSBCT was fractionated into several...
Retinopathy of prematurity (ROP) and infantile hemangiomas (IHs) both have similar proposed pathophysiological mechanisms. IH is more common in preterm than term infants. Hypoxia-induced mediators like vascular endothelial growth factor been found elevated children with hemangiomas. The aim our study was to determine if there an association between ROP infants investigate racial/ethnic gender differences IHs this cohort.We accessed the national multicenter Kids' Inpatient Database (KID)...
Abstract We sought to determine whether there are sex-based differences in the requirements for calories or protein optimal growth during transition phase (TP) when an extremely low birth weight (ELBW) infant, defined as a preterm infant with of < 1000 g, is progressing from parenteral enteral feeds. A retrospective review ELBW infants born 2014 2016 was performed at tertiary NICU. Infants necrotizing enterocolitis, short bowel syndrome, chromosomal anomalies were excluded. TP period...
with either I or 6-under the abovenon-aqueous conditions36 failedio provide desired adducts.Wc have not studied these reactions under Lewis acid catalysis high pressure conditions.
N-Acyl-N′-monosubstituted thioureas (9) react with phenacyl bromide to produce thiazolines (10) and not thiazoles (4), as claimed. The addition products of N-arylbenzamidines phenyl isothiocyanate give 2-anilino-5-benzoyl-4-phenylthiazole (4a). adduct (11) methyl benzimidate yields (4a) (12) by reaction bromonitromethane, respectively.
An extremely premature infant born at a gestational age 24 5/7 and birth weight of 637 g was found to have retained distal segment an umbilical venous catheter (UVC) on chest radiograph after removal the UVC. The retrieved by interventional radiology day 10 life when baby weighed 660 g. To our knowledge, this is smallest reported successfully percutaneously via femoral access.
Several 14-α-aminomethyl-substituted lanosterol derivatives have been synthesized involving a complete Δ7,8to Δ8,9isomerization; these compounds are inhibitors of fungal ergosterol biosynthesis and active against intact Candida dermatophyte strains.
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has significant health implications. Anemia is usually an unseen comorbidity, which could significantly affect outcomes in AECOPD patients, and there limited data to support this. We conducted this study assess the effect anemia on patient population.We performed a retrospective cohort using National (Nationwide) Inpatient Sample (NIS) from 2008 2014. Patients with age >40 years were identified appropriate International...
Abstract Harlequin ichthyosis ( HI ) is associated with high mortality. Early systemic retinoids are widely used, although their use remains debatable. We reported two neonates homozygous mutations in ABCA 12 consistent harlequin who survived to discharge home intensive care and without of retinoids.