A5101827779- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Plant and Fungal Species Descriptions
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
- Plant Parasitism and Resistance
- Lung Cancer Research Studies
- Genomics and Phylogenetic Studies
- Plant Diversity and Evolution
- Hepatitis B Virus Studies
- Chromatin Remodeling and Cancer
- Hepatitis C virus research
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Plant Pathogens and Fungal Diseases
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2023
National Clinical Research
2021
Peking Union Medical College Hospital
2012-2017
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most these studies were retrospective, using individuals previously diagnosed with cancer as cases healthy controls. Here, we developed a liquid biopsy assay, named hepatocellular carcinoma screen (HCCscreen), identify HCC from surface antigen hepatitis B virus (HBsAg) positive asymptomatic in community population. The training cohort...
// Hong Zhao 1,* , Yuming Guo 2,* Shu Li 2 Ruiqin Han 3 Jianming Ying 4 Hai Zhu Yuanyuan Wang Yin Yuqing Lingzhi Sun Zhaoyi Qingcong Lin Xinyu Bi 1 Yuchen Jiao 5 Hongying Jia Jianjun Zhen Huang Zhiyu Jianguo Zhou Wei Song Kun Meng and Jianqiang Cai Department of Abdominal Surgical Oncology, Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, P.R. China Beijing Shenogen Biomedical Co., Ltd, National Laboratory Molecular Biology, Institute Basic Sciences,...
More than 30 Ligularia Cass. (Asteraceae) species have long been used in folk medicine China. Morphological features and common DNA regions are both not ideal to identify species. As some contain pyrrolizidine alkaloids, which hazardous human animal health involved metabolic toxification the liver, it is important find a better way distinguish these Here, we report complete chloroplast (CP) genomes of six species, L. intermedia, jaluensis, mongolica, hodgsonii, veitchiana, fischeri, obtained...
Papaver rhoeas L. and P. orientale L., which belong to the family Papaveraceae, are used as ornamental medicinal plants. The chloroplast genome has been for molecular markers, evolutionary biology, barcoding identification. In this study, complete sequences of reported. Results show that genomes have typical quadripartite structures, comprised circular 152,905 152,799-bp-long molecules, respectively. A total 130 genes were identified in each genome, including 85 protein-coding genes, 37 tRNA...
The family Aristolochiaceae, comprising about 600 species of eight genera, is a unique plant containing aristolochic acids (AAs). complete chloroplast genome sequences Aristolochia debilis and contorta are reported here. results show that the genomes A. comprise circular 159,793 160,576 bp-long molecules, respectively have typical quadripartite structures. GC contents both were 38.3% each. A total 131 genes identified in each including 85 protein-coding genes, 37 tRNA rRNA one pseudogene...
The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 upregulated human colorectal cancer promotes proliferation when overexpressed a colon line. interacts with mitochondrial Ca2+ uniporter (MCU) to promote by increasing uptake energy metabolism. ubiquitination site of (RIPK1-K377) was critical this interaction MCU function promoting proliferation. These findings identify the...
Numerous variations are known to occur in the chloroplast genomes of parasitic plants. We determined complete genome sequences two hemiparasitic species, Taxillus chinensis and T. sutchuenensis, using Illumina PacBio sequencing technologies. These species first members family Loranthaceae be sequenced. The sutchuenensis comprise circular 121,363 122,562 bp-long molecules with quadripartite structures, respectively. Compared Nicotiana tabacum Osyris alba, all ndh genes as well three ribosomal...
To predict clinical important outcomes for colorectal liver metastases (CRLM) patients receiving resection with simultaneous by integrating demographic, clinical, laboratory, and genetic data.
The genus Corydalis is recognized as one of the most taxonomically challenging plant taxa. It mainly distributed in Himalaya-Hengduan Mountains, a global biodiversity hotspot. To date, no effective solution for species discrimination and taxonomic assignment has been developed. In this study, five nuclear chloroplast DNA regions, ITS, ITS2, matK, rbcL, psbA-trnH, were preliminarily assessed based on their ability to discriminate eliminate inefficient three regions showing good performance...
Background: The optimal number of neoadjuvant chemotherapy (NAC) cycles for resectable colorectal liver oligometastases (CLOM) remains unclear. aim this study was to investigate the NAC cycles.
This study aimed to investigate the clinicopathological features and prognosis of gallbladder neuroendocrine carcinoma (GB-NEC).Fifteen patients with GB-NEC 171 adenocarcinoma (GB-ADC) treated in two tertiary medical centers between 2009 2015 were included. The prognostic risk factors analyzed retrospectively. A propensity score matching a 1:2 ratio was used compare GB-ADC.For GB-NEC, median age 58.4 years (range 26-75), M:F 7:8. Based on 2010 WHO classification, ten cases pathologically...
Research on the chloroplast genome of parasitic plants is limited. In particular, homology between genomes and hyperparasitic has not been reported yet. this study, three Taxillus (Taxillus chinensis, delavayi, thibetensis) one Phacellaria (Phacellaria rigidula) were sequenced analyzed, among which T. chinensis host P. rigidula. The four species 119,941–138,492 bp in length. Compared with autotrophic plant Nicotiana tabacum, all ndh genes, ribosomal protein tRNA genes infA gene lost species....
Abstract Background Recent studies suggest red blood cell distribution width (RDW) was a prognostic factor in various types of cancer patients, although the results are controversial. The objective this study to investigate significance RDW patients with intrahepatic cholangiocarcinoma (ICC) after radical resection. Method relationship between preoperative serum value and clinic pathological characteristics analyzed 157 ICC January 2012 June 2018 who underwent curative X-tile software used...
Dendrobium officinale is an extremely valuable orchid used in traditional Chinese medicine, so sought after that it has a higher market value than gold. Although the expression profiles of some genes involved polysaccharide synthesis have previously been investigated, little research carried out on their alternatively spliced isoforms D. officinale. In addition, information regarding translocation sugars from leaves to stems also remains limited. We analyzed content and stems, completed...
The safety of the simultaneous resection synchronous colorectal cancer liver metastases (SCRLM) is still being debated. However, this operative approach more commonly adopted at present than in past. Therefore, we compared hepatic with delayed study.All patients SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included our study. Short-term long-term outcomes who underwent those treated by hepatectomy.Among 73 SCRLM, was performed 60...
Macrosolen plants are parasitic shrubs, several of which important medicinal plants, that used as folk medicine in some provinces China. However, reports on limited. In this study, the complete chloroplast genome sequences cochinchinensis, tricolor and bibracteolatus reported. The genomes were sequenced by Illumina HiSeq X. length ranged from 129,570 bp (M. cochinchinensis) to 126,621 tricolor), with a total 113 genes, including 35 tRNA, eight rRNA, 68 protein-coding two pseudogenes (ycf1...
The purpose of this study was to investigate the prognostic factors carcinoma ampulla Vater (CAV) after surgery. clinicopathological related recurrence and prognosis 162 CAV patients surgical resection were retrospectively analyzed using univariate multivariate methods. in-hospital mortality rate 4.32 % 5-year disease-free survival overall subjects 55.1 51.7 %, respectively. Univariate analysis revealed that an advanced T stage (P = 0.002), lymph nodal metastasis poor differentiation 0.006),...
Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of hepatocellular carcinoma (HCC) or chronic hepatitis B infection (CHB). However, relationship between these genetic variants and survival patients virus (HBV)-related HCC is still unknown. In this study, 22 single nucleotide polymorphisms (SNPs) were genotyped among 330 HBV-related using MassARRAY system from Sequenom. Cox proportional hazards regression was used to...
To investigate the predictive value of pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for prognosis in colorectal liver metastases (CRLM) patients after hepatic resection.Two hundred ninety-two between December 2008 2016 101 at our center from January 2017 to 2018 were selected as a training set validation set, respectively. The combination GGT status (CPDG score) was scored follows: elevated levels with allocated score 2, decreased 0, all other combinations 1. In logistic...
// Rui Mao 1, * , Jian-Jun Zhao Xin-Yu Bi Ye-Fan Zhang 1 Zhi-Yu Li Jian-Guo Zhou Xiao-Long Wu Chen Xiao Hong and Jian-Qiang Cai Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, 100021, China These authors contributed equally to this work Correspondence to: Cai, email: caijianqiang@cicams.ac.cn Zhao, zhaohong@cicams.ac.cn Keywords: colorectal liver metastases, hepatectomy, early recurrence, risk...