A5100408276- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Cholinesterase and Neurodegenerative Diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Analysis
- Cancer Cells and Metastasis
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Chemokine receptors and signaling
- Natural product bioactivities and synthesis
- Research in Cotton Cultivation
- Chromatography in Natural Products
- Machine Learning in Healthcare
- Immune cells in cancer
- Diabetes and associated disorders
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Metabolomics and Mass Spectrometry Studies
Public Health Clinical Center of Chengdu
2024-2025
Chengdu University of Traditional Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Xiamen University of Technology
2024
Xiamen Medical College
2024
Henan University of Science and Technology
2024
Nantong University
2023-2024
Northwest Normal University
2014-2023
Zhejiang Gongshang University
2022-2023
Yantai Academy of Agricultural Sciences
2023
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most these studies were retrospective, using individuals previously diagnosed with cancer as cases healthy controls. Here, we developed a liquid biopsy assay, named hepatocellular carcinoma screen (HCCscreen), identify HCC from surface antigen hepatitis B virus (HBsAg) positive asymptomatic in community population. The training cohort...
Neonatal hepatitis B vaccination has been implemented worldwide to prevent virus (HBV) infections. Its long-term protective efficacy on primary liver cancer (PLC) and other diseases not fully examined.The Qidong Hepatitis Intervention Study, a population-based, cluster randomized, controlled trial between 1985 1990 in Qidong, China, included 39,292 newborns who were randomly assigned the group which 38,366 participants completed HBV series 34,441 control received neither vaccine nor placebo....
Cell-free DNA (cfDNA)–based liquid biopsy is a promising approach for the early detection of cancer. A major hurdle limited yield cfDNA from one blood draw, limiting use most samples to test either mutation or methylation. Here, we develop technology, Mutation Capsule Plus (MCP), which enables multiplex profiling sample, including simultaneous genetic and epigenetic alterations genome-wide discovery methylation markers. With this performed de novo screening markers on 30 hepatocellular...
In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) butyrylcholinesterase (BuChE), differences in the inhibition AChE described. Although they differ structure by a single methyl group, inhibitory effect G1 (IC50=264 nmol/L) on was 80 times stronger than that G2 (IC50=21,210 nmol/L). Enzyme-kinetic analysis, molecular docking dynamics (MD) simulations were conducted to better understand basis for difference. The results obtained...
Chinese medicine Wuzi Yanzong pill (WZYZP) was firstly documented in ancient medical works "She Sheng Zhong Miao Fang" by Shi-Che Zhang 1550 AD. The traditional herbal formula is widely used treating nephrasthenia lumbago, prospermia, erectile dysfunction and male sterility. present study to explore the effects of WZYZP on ionizing irradiation-induced testicular damage mice. pelvic region mice exposed X-rays for inducing damage. were evaluated terms testes weight, sperm quantity motility,...
Chemokine-like factor 1 (CKLF1) is a novel functional cytokine that acts through its receptor CC chemokine 4 (CCR4). Activation of CCR4 by CKLF1 plays an important role in diseases such as asthma and multiple sclerosis. This article describes cell-based screening assay using FITC-labeled agonist (CKLF1-C27), peptide fragment. Screening our in-stock small-molecule library identified 3-piperazinylcoumarin analogue (IC50 = 4.36 × 10−6 M) led to the discovery orally active compound 41 2.12 10−8...
Background The association between choroidal changes and diabetic retinopathy pathophysiology remains unclear. Objective We aimed to assess thickness (CT) in patients with Non-Proliferative Diabetic Retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT) compare it that of healthy individuals. Methods included NPDR (NPDR group) individuals (control group). All the enrolled eyes were examined SS-OCT, CT measurements obtained within a 6×6 mm area centered on macular fovea....
Caspase-1 is a key player in pyroptosis and inflammation. inhibition found to be beneficial various diseases. Coumarin-originated natural products have an anti-inflammation function, but their direct effect caspase-1 remains unexplored. To evaluate interactions, the widely used commercial coumarin-based probe (Ac-YVAD-AMC) not suitable, as background signal from coumarin-originated could interfere with screening results. Therefore, fluorescent probes using large Stokes shift help solve this...
Celastrol (CEL), a pentacyclic triterpene compound, has been proven to have definite antipulmonary fibrosis effect. However, its direct targets for remain unknown. In this study, we designed and synthesized series of celastrol-based probes identify the in human pulmonary fibroblasts using an activity-based protein profiling strategy. Among many fished targets, identified key protein, cullin-associated neddylation-dissociated 1 (CAND1), which was involved fibroblast–myofibroblast...