A5070093859- Health Systems, Economic Evaluations, Quality of Life
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Healthcare Policy and Management
- Rheumatoid Arthritis Research and Therapies
- Hepatitis C virus research
- Lipid metabolism and disorders
- Primary Care and Health Outcomes
- Blood Pressure and Hypertension Studies
- Global Health Care Issues
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacology and Obesity Treatment
- Nuclear Receptors and Signaling
- Pathogenesis and Treatment of Hiccups
- Neurological Complications and Syndromes
- Inflammatory Biomarkers in Disease Prognosis
- Global Health Workforce Issues
- Fibroblast Growth Factor Research
- Health, Environment, Cognitive Aging
- HIV-related health complications and treatments
- Sulfur Compounds in Biology
China-Japan Friendship Hospital
2008-2024
Kaiser Permanente
2022
Maastricht University
2022
Acorda Therapeutics (United States)
2022
Beijing University of Chinese Medicine
2022
Second Military Medical University
2022
Shanghai Changzheng Hospital
2022
Boston Medical Center
2022
University Medical Center
2022
Boston University
2022
Background Persons with diabetes are at high risk of developing diabetic kidney disease (DKD), which is associated morbidity and mortality. Current drug therapies for DKD, such as angiotensin-converting enzyme inhibitors (ACEIs) angiotensin receptor blockers (ARBs), not entirely satisfactory. This study aimed to evaluate the additional benefit safety Chinese herbal granule Tangshen Formula (TSF) in treating DKD. Methods The was designed a six-center randomized, double-blind,...
Background: Hypertension is one of the most challenging public health problems worldwide. Previous studies suggested that Songling Xuemaikang capsule (SXC)—a Chinese herbal formula—was effective for essential hypertension. However, efficacy SXC monotherapy hypertension remains unclear. We aimed to compare blood pressure (BP)–lowering and safety versus losartan in patients with Methods: In this multicenter, randomized, double-blind, noninferiority trial China, 18 65 years age mild were...
Objective: Extensive studies have shown that ERS may be implicated in the pathogenesis of DCM. We explored therapeutic effects lncRNAH19 on DCM and its effect ERS-associated cardiomyocyte apoptosis. Methods: C57/BL-6j mice were randomly divided into 3 groups: non-DM group (controls), DM (DCM), overexpression (DCM+H19 group). The H19 cardiac function was detected. apoptosis fibrosis examined. Differentially expressed genes (DEGs) activated pathways examined by bioinformatics analysis. STRING...
Long-term use of cocaine (⩾15 years) and antiretroviral therapy (ART) have been implicated in cardiovascular complications. Nevertheless, the individual combined effects ART on silent coronary artery disease not fully investigated.Methods: Computed tomography angiography was performed for 165 human immunodeficiency virus (HIV)– infected African American study participants aged 25–54 years Baltimore, Maryland, with contrast-enhanced 64-slice multidetector computed imaging.Result: Significant...
A regular heart rate is a critical indicator of human health. However, when the heart's rhythm or deviates from norm due to various factors, an arrhythmia occurs. Atrial fibrillation (AF) most prevalent form arrhythmia, with its incidence tripling over past 50 years. Studies have shown strong correlation between sleep disorders and onset atrial fibrillation. Most current studies on quality patients rely subjective questionnaires, notable lack objective assessments. This study utilizes data...
This study includes exploring (i) the production of endogenous hydrogen sulfide (H2 S) after mucosal wound generation and (ii) role compensating change in H2 S level postmucosal generation.A model was established female C57BL/6J mice. Wound tissues were collected to examine level. To effect decreased S, GYY4137 intraperitoneally injected into mice at 50 mg kg-1 day-1 before wounding compensate for S. Finally, we confirmed inhibiting M1 phenotype macrophage activation induced by LPS...
This study aims to investigate the regulatory effect of Xuesaitong (XST) and miR-3158-3p on angiogenesis. All mice were randomly assigned into Sham group, Model XST + miR-3158-3P-overexpression (miRNA-OE) group. was found increase left ventricular anterior wall thickness at end diastole systole (LVAWd LVAWs), internal dimension (LVIDd LVIDs), fractional shortening (FS), ejection fraction (EF) decrease proportion fibrotic areas in mice. In contrast those protein expressions Nur77, p-PI3K,...
Abstract Purpose Mapping the Minnesota Living with Heart Failure Questionnaire (MLHFQ) to SF-6Dv2 in Chinese patients chronic heart failure, and obtain health utility value for economic assessment. Methods Four statistical algorithms, including ordinary least square method (OLS), Tobit model, robust MM estimator (MM) censored absolute deviations (CLAD), were used establish alternative model. Models validated by using a tenfold cross-validation technique. The mean error (MAE) root (RMSE)...
Background and purpose: The histamine H 3 receptor antagonist radioligand [ H]‐A‐349821 was characterized as a radiotracer for assessing in vivo occupancy by antagonists that affect behaviour. This model established an alternative to ex binding methods, relating blood levels efficacy preclinical models. Experimental approach: In cerebral cortical determined rats from differences the isolated cortex cerebellum, brain region with low of receptors. Comparisons were made relate cognition,...
To analyze the development of cardio-oncology, summarize research achievements, and provide proposals for its future research.The web science database was used to search "cardio-oncology" "oncocardiology" related articles from beginning (1970) April 5, 2019. Excel 2016 Cytoscape were trend cardio-oncology research.A total 356 obtained. The number has grown rapidly in recent years. Cardiac injury caused by tumor therapy a hotspot (n = 107). Researchers paid more attention prevention treatment...
To develop a claims-based severity index for rheumatoid arthritis (RA) using the Veterans Health Administration (VHA) database.Adult patients with at least two RA diagnoses 2 months apart were identified between 10/1/2008-09/30/2009. Patients required to have 12 continuous health plan enrollment before and after date (first diagnosis date) an overall study period of 10/1/2007-09/30/2010. A (SIFRA, proprietary algorithm SIMR, Inc. [STATinMED Research]) was developed by calculating weighted...
Contrast-induced encephalopathy (CIE) is a complication associated with the administration of iodinated contrast, which usually happens minutes to hours after contact and fully recovers within 72 h. The clinical manifestations CIE are diverse, pathological mechanism not explicit.We report case 66-year-old female who suffered from delayed following contrast agent. Symptoms were severe. Imaging examination, biochemical etiological detection performed timely. course neurological symptoms was...
The purpose of this study was to estimate the minimum clinically important differences (MCIDs) in Minnesota Living with Heart Failure questionnaire (MLHFQ), which targeted patients heart failure treated integrated Chinese and Western medicine, as a means helping doctors judge effectiveness intervention. A total 194 chronic were recruited from three general hospitals Beijing. Anchor-based distribution-based approaches used MCID. anchor SF-36 item 2 (HT, Health Transition), calculation methods...
To compare mortality, healthcare utilization and cost burden of patients who suffered major bleeding during the 180 days after diagnosis non-valvular atrial fibrillation (NVAF) with did not. Based on 2005-2007 U.S. Medicare advantage insurance claim files, aged 65 years older have had two or more primary diagnoses for NVAF occurring within 30 one another were selected. The 180-day follow-up facility use costs without compared. Risk adjustment was performed using propensity score matching...