A5100404331- Selenium in Biological Systems
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Environmental Toxicology and Ecotoxicology
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Medicinal Plant Pharmacodynamics Research
- Mercury impact and mitigation studies
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- Fluoride Effects and Removal
- Moringa oleifera research and applications
- Microplastics and Plastic Pollution
- Toxic Organic Pollutants Impact
- Helminth infection and control
- Insect and Pesticide Research
- Effects and risks of endocrine disrupting chemicals
- Immunotoxicology and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- Nanoparticles: synthesis and applications
Northeast Agricultural University
2016-2025
Sixth Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2023-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2023-2024
Xi'an Shiyou University
2024
University of Louisville
2023-2024
Shanghai University of Traditional Chinese Medicine
2024
Shanghai Jiao Tong University
2013-2024
Jiujiang University
2018-2024
Jiangnan University
2024
Nanoplastics are emerging pollutants that pose potential threats to the environment and organisms. However, in-depth research on nanoplastics has been hindered by absence of feasible reliable analytical methods, particularly for trace nanoplastics. Herein, we propose a hyphenated method involving membrane filtration surface-enhanced Raman spectroscopy (SERS) analyze in water. In this method, bifunctional Ag nanowire was employed enrich enhance their spectra situ, which omitted sample...
Mechanosensitive PIEZO channels are thought to open their pore through tension-induced flattening of large transmembrane arm domains. Yet, the structural basis this activation remains unclear. Here, we uncover conformational coupling between and opening in PIEZO2 by capturing protein motions across length scales using hybrid-resolution molecular dynamics simulations. Sampling multiple microsecond-long trajectories under physiological tension show that correlates with anticlockwise rotation...
// Hong Zhao 1,* , Yuming Guo 2,* Shu Li 2 Ruiqin Han 3 Jianming Ying 4 Hai Zhu Yuanyuan Wang Yin Yuqing Lingzhi Sun Zhaoyi Qingcong Lin Xinyu Bi 1 Yuchen Jiao 5 Hongying Jia Jianjun Zhen Huang Zhiyu Jianguo Zhou Wei Song Kun Meng and Jianqiang Cai Department of Abdominal Surgical Oncology, Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, P.R. China Beijing Shenogen Biomedical Co., Ltd, National Laboratory Molecular Biology, Institute Basic Sciences,...
Selenium deficiency affects differentiation and immune function of dendritic cells.
The regeneration of adult skeletal muscle after injury is primarily initiated by satellite cells (SCs), but the regulatory mechanisms committed to myogenic differentiation remain poorly explored. Small molecular selenoprotein K (SelK) plays crucial roles in modulation endoplasmic reticulum (ER) stress and against oxidative stress. Here, we first showed that SelK expression activated during both vivo vitro. Meanwhile, loss delayed regeneration, inhibited development myoblasts into myotubes,...
Plastics are novel environmental pollutants with potential threats to the ecosystem. At least 5.25 trillion plastic particles in environment, of which nanoplastics <100 nm diameter. Polystyrene (PS-NPs) exposure damaged spleen's immune function. Lipopolysaccharide (LPS) induced other toxicants damage cells and organs, triggering inflammation. However, mechanism PS-NPs aggravated LPS-induced spleen injury remains unclear. In this study, or/and LPS mice model was replicated by intraperitoneal...
Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be widely detected in the environment and living organisms. Accumulating evidence has shown that PFOS breaks through different biological barriers resulting cardiac toxicity, but underlying molecular mechanisms remain unclear. Cannabidiol (CBD) is nonpsychoactive cannabinoid without potential adverse cardiotoxicity antioxidant anti-inflammatory properties reduce multiorgan damage dysfunction. For these reasons,...
Tetrabromobisphenol A (TBBPA), a non-degradable environmental pollutant, was discharge into the air during manufacture, use and recycling of plastic products. Respiratory exposure is main way to inhalation TBBPA. However, research on damage TBBPA respiratory system still extremely few. The aim this experiment explore mechanism toxicity lungs. Forty C57BL/6 J mice randomly divided 4 groups, experimental groups with at 10 n M/kg, 20 M/kg 40 for 14 consecutive days. Histopathological...
As a new type of persistent organic pollutant, perfluorooctane sulphonate (PFOS) has received extensive attention worldwide. Cannabidiol (CBD) is non-psychoactive natural cannabinoid extract that been proved to have antioxidation, regulation inflammation and other functions. However, the effects PFOS on liver injury whether CBD can alleviate PFOS-induced are still unclear. Therefore, in this study, we used (10 mg/kg) and/or (5 intraperitoneally inject mice for 30 days. We found exposure led...
Perfluorooctane sulfonate (PFOS) is one of the persistent organic pollutants (POPs), which can cause severe nephrotoxicity in mammals. Cannabinol (CBD), a nonpsychoactive cannabinoid obtained from cannabis plant, has attracted attention recent years for its excellent antioxidant properties. NADPH oxidase 4 (NOX4) an important effect supporting normal renal physiological function. The potential mechanisms PFOS and whether CBD prevent damage caused by remain unclear. This work aimed to study...