A5101960438- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Entomopathogenic Microorganisms in Pest Control
- Insect symbiosis and bacterial influences
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Mycobacterium research and diagnosis
- Insect Utilization and Effects
- Mitochondrial Function and Pathology
- Cancer Genomics and Diagnostics
- 14-3-3 protein interactions
- Invertebrate Immune Response Mechanisms
- Studies on Chitinases and Chitosanases
- Lepidoptera: Biology and Taxonomy
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Macrophage Migration Inhibitory Factor
- Neurological diseases and metabolism
- Metabolomics and Mass Spectrometry Studies
- Medical and Biological Ozone Research
Nanjing Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Chinese PLA General Hospital
2025
Westlake University
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Northeast Forestry University
2020-2024
Anhui Provincial Children's Hospital
2018-2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2019-2022
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022
Tianjin University of Traditional Chinese Medicine
2022
By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic candidate gene approaches search for evidence such genetic First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders Tibetan Plateau (3,200–3,500 m) closely related lowland Han revealed significant divergence across eight SNPs located near EPAS1 . This encodes...
Selenium deficiency affects differentiation and immune function of dendritic cells.
Metastasis is responsible for the rapid recurrence and poor survival of malignancies. Epithelial-mesenchymal transition (EMT) has a critical role in metastasis. Increasing evidence indicates that EMT can be regulated by microRNAs (miRNAs). The aim this study was to investigate miR-26b modulating epithelial-mesenchymal hepatocellular carcinoma (HCC), as well identify its underlying mechanism action. expression level assessed multiple HCC cell lines (HepG2, MHCC97H, Hep3B, MHCC97L, HCCC9810,...
Patients with non-Hodgkin lymphoma (NHL) face heightened mortality and accelerated disease progression when persistently infected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This critical situation underscores the urgent need to identify risk factors establish early intervention strategies tailored this vulnerable population. The primary aim of study was investigate associated persistent SARS-CoV-2 infection in NHL patients during COVID-19 pandemic. A retrospective cohort...
Lycopene is a natural carotenoid with antioxidation properties. The objective of the present study was to investigate roles glutamate and proline in lycopene biosynthesis newly isolated purple non-sulfur bacterium Cereibacter sphaeroides DT.1, under aerobic conditions. This strain contained distinct CrtI4 capable converting phytoene via four-step desaturation. In order enhance production, crtC knockout mutant constructed homologous recombination. Supplementation or fermentative medium...
Abstract BACKGROUND Gypsy moth ( Lymantria dispar ) is one of the most important pests in world. Emamectin benzoate (EMB) widely used control agricultural and forestry pests. Here, we explored sublethal effects EMB on gypsy moths order to better understand toxicological mechanism EMB. RESULTS The concentration exposure significantly decreased larvae body weight. To further explore mechanism, indicators related digestion nutrient metabolism were detected. results showed that caused midgut...
Abstract Selenium (Se) deficiency induces typical clinical and pathological changes causes various responses at the molecular level in several different chicken organs; kidney is one of target organs Se deficiency. To explore mechanisms that underlie effects microRNA‐33‐3p (miR‐33‐3p) on deficiency‐induced apoptosis, 60 chickens were randomly divided into two groups (30 per group). We found increased expression miR‐33‐3p kidney. A disintegrin metalloprotease domain 10 (ADAM10) was verified...
The aim of this study was to investigate the mechanism cadmium-induced apoptosis in chicken spleens and antagonistic effects selenium. We duplicated selenium-cadmium interaction model examined expression apoptosis-, immune-, mitochondrial dynamics- energy metabolism-related genes. results demonstrated that after treatment with cadmium, frequency significantly increased, morphological characteristics were observed. pro-apoptotic genes anti-apoptotic decreased. mRNA levels tumor necrosis...
Vein endothelial cells (VECs) constitute an important barrier for macromolecules and circulating from the blood to tissues, stabilizing colloid osmotic pressure of blood, regulating vascular tone, rapidly changing intercellular connection, maintaining normal physiological function. Tight junction has been discovered as structural basis connection may play a key role in injuries or diseases selenium (Se) deficiency symptoms. Hence, we replicated Se‐deficient broilers model detected specific...
Abstract Selenium (Se) is an essential trace element that has several functions in cellular processes related to cancer prevention. While the cancericidal effect of Se been reported liver cancer, mechanism not clarified. MiR-29a widely as a tumor suppressor; however, it also acts carcinogenic agent by increasing cell invasion human epithelial cells and hepatoma cells. In previous study, we found miR-29a-3p Se-sensitive miRNA. However, its chicken hepatocellular carcinoma line (LMH) still...
Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) could regulate biological activities cells and unravel underlying mechanisms.CRC corresponding adjacent tissues were collected expression MAFG-AS1, microRNA-149-3p (miR-149-3p)...
Abstract BACKGROUND Lymantria dispar is an economically impactful forest pest worldwide. The entomopathogenic fungi Beauveria bassiana shows great promise in management due to its high lethality . A complete understanding of the immune interactions between and pathogenic fungus essential actualizing biological management. RESULTS Following infection by spores, we performed a time‐course analysis transcriptome fat bodies hemocytes explore host response. total 244 immunity‐related genes...
Emamectin benzoate (EMB) is a semisynthetic bioinsecticide, which has been widely used in the control of forestry and agricultural pests. However, mechanism its toxic effects on non-neural tissues rarely reported. Here, we explored midgut damage induced by EMB gypsy moth (Lymantria dispar) order to better understand toxicological EMB.Our results confirmed that caused inducing apoptosis. Transcriptome showed 1469, 650 950 genes were significantly differentially expressed after 24, 48 72 h...
The aim of this work was to explore the microRNA profile and effect microRNA-155 on apoptosis in spleen selenium-deficient broilers. We replicated splenic-apoptotic model In vitro, oligonucleotides were transfected into lymphocytes subsequently treated with H2O2. observed that selenium deficiency altered decreased expression broiler spleens. Tumor necrosis factor receptor superfamily member 1B verified as a target splenocytes. Morphological changes, increased levels tumor 1B, c-Jun...
MicroRNAs (mRNAs or miRs) serve an important role in the regulation of gene expression. In present study, miR-98-5p bone regeneration was determined. Three osteoblast cell models were established, including primary human stem cells (BMMSC), mouse BMMSC's and MC3T3-E1 cells. expression determined using reverse transcription-quantitative (RT-q)PCR. Osteoblast markers, alkaline phosphatase, runt related transcription factor 2 Sp7, RT-qPCR western blot analysis, respectively. Alkaline...